Protein Alignment Ugt37C1 and UGT1A3

DIOPT Version :10

• Sequence 1: NP_525007.2
• Gene: Ugt37C1 / 53583
• FlyBaseID: FBgn0026754
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_061966.1
• Gene: UGT1A3 / 54659
• HGNCID: 12535
• Length: 534
• Species: Homo sapiens
• Alignment Length: 565
• Identity: 151/565 - (26%)
• Similarity: 264/565 - (46%)
• Gaps: 99/565 - (17%)

  Fly     8 SAIVWLLAVASPSQGANILGVYSALSPSHLIIHMSTAKALAEAGHNVTVVSMMQPKV-MH----- 66
            :.::.||:|...::...:|.|  .:..||.:......:.|...||...|::   |:| ||
Human    14 TGLLLLLSVQPWAESGKVLVV--PIDGSHWLSMREVLRELHARGHQAVVLT---PEVNMHIKEEN 73

  Fly    67 ---------------KDIHLI-VVPVTKEQERTLENQMASMAGSKNNIITTMYLLLNGLDVMV-T 114
                           .|.|:: ...:..|.|..|:....|||            :||.:.::. .
Human    74 FFTLTTYAISWTQDEFDRHVLGHTQLYFETEHFLKKFFRSMA------------MLNNMSLVYHR 126

  Fly   115 SQADLL-KDPRFQRVFETKFDLMILGSFFNDFQLGVAGKLKVPVIVDWMIPSNTMIDEFVAN--- 175
            |..:|| .:...:.:..|.|| ::|....|.....:|..|.:|.:.            |:.|
Human   127 SCVELLHNEALIRHLNATSFD-VVLTDPVNLCAAVLAKYLSIPTVF------------FLRNIPC 178

  Fly   176 ---------PSEVSYVPNESTFATTPMSFFKRAENLVKHVILKYLTIRFNYKFNRIYNEIFTDKD 231
                     |:..||:|...|..:..|:|.:|.:|::..:.|.|:...|:..:..:.:|:|
Human   179 DLDFKGTQCPNPSSYIPRLLTTNSDHMTFMQRVKNMLYPLALSYICHAFSAPYASLASELF---- 239

  Fly   232 MPTLSEMKKNISMVFVGSH---------LISDGPIRPLVPAIIEVGGIQVKEQPDPLPQDIEQFM 287
                   ::.:|:|.:.||         .:.|.| ||::|.::.:|||....: .||.|:.|.::
Human   240 -------QREVSVVDILSHASVWLFRGDFVMDYP-RPIMPNMVFIGGINCANR-KPLSQEFEAYI 295

  Fly   288 ENSSQ-GAIFLSFGSNIKSYMVKPEIVGIMFKVLSGLKQNVIWKWEDLENTPGN-ASNIFYKDWL 350
            ..|.: |.:..|.||.:.....|..:.  :...|..:.|.|:|::..  ..|.| |:|.....||
Human   296 NASGEHGIVVFSLGSMVSEIPEKKAMA--IADALGKIPQTVLWRYTG--TRPSNLANNTILVKWL 356

  Fly   351 PQDDILAHPNTKLFVTHAGKGSITESQYHGVPMVALPIFGDHPLNAALMVNSGYGVSLDLQTITE 415
            ||:|:|.||.|:.|:||||...:.||..:|||||.:|:|||...||..|...|.||:|::..:|.
Human   357 PQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTS 421

  Fly   416 DTFREAINEVLENDKYTQAVRKFSALYRDRPLTPRQSVLFWVDYVLRHHGAPNLQSPAVH-MGFV 479
            :....|:..|:.:..|.:.:.:.|:|::|||:.|....:|||::|:||.|||:|: ||.| :.:.
Human   422 EDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLR-PAAHDLTWY 485

  Fly   480 ELHNLDIYALVLAILIFLVFLTRLTVKFLFSKLLGKAKVPARKKK 524
            :.|:||:...:||:::.:.|:|.....:.:.|.|||   ..|.||
Human   486 QYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGK---KGRVKK 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C1	NP_525007.2	Glycosyltransferase_GTB-type	39..517	CDD:471961	141/525 (27%)
UGT1A3	NP_061966.1	UDPGT	29..525	CDD:278624	145/546 (27%)