Protein Alignment Ugt37C1 and UGT1A4

DIOPT Version :9

• Sequence 1: NP_525007.1
• Gene: Ugt37C1 / 53583
• FlyBaseID: FBgn0026754
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_009051.1
• Gene: UGT1A4 / 54657
• HGNCID: 12536
• Length: 534
• Species: Homo sapiens
• Alignment Length: 526
• Identity: 150/526 - (28%)
• Similarity: 255/526 - (48%)
• Gaps: 82/526 - (15%)

  Fly     1 MSTAKALAE---AGHNVTVVSMMQPKV-MH------------------KDIHLIVVPVTK---EQ 40
            :|..:||.|   .||...|::   |:| ||                  |:...:.:..|:   |.
Human    42 LSMREALRELHARGHQAVVLT---PEVNMHIKEEKFFTLTAYAVPWTQKEFDRVTLGYTQGFFET 103

  Fly    41 ERTLENQMASMAGSKNNIITTMYLLLNGLDVMVTSQADLLKDPRFQRVFETKFDLMILGSFFNDF 105
            |..|:....|||     |:..:.|.|:...|.:.....|::     .:..|.|| ::|....|..
Human   104 EHLLKRYSRSMA-----IMNNVSLALHRCCVELLHNEALIR-----HLNATSFD-VVLTDPVNLC 157

  Fly   106 QLGVAGKLKVPVIVDW-MIPSNTMIDEF----VANPSEVSYVPNESTFATTPMSFFKRAENLVKH 165
            ...:|..|.:|.:..| .||.:.   :|    ..|||  ||:|...|..:..|:|.:|.:|::..
Human   158 GAVLAKYLSIPAVFFWRYIPCDL---DFKGTQCPNPS--SYIPKLLTTNSDHMTFLQRVKNMLYP 217

  Fly   166 VILKYLTIRFNYKFNRIYNEIFTDKDMPTLSEMKKNISMVFVGSH---------LISDGPIRPLV 221
            :.|.|:...|:..:..:.:|:|           ::.:|:|.:.|:         .:.|.| ||::
Human   218 LALSYICHTFSAPYASLASELF-----------QREVSVVDLVSYASVWLFRGDFVMDYP-RPIM 270

  Fly   222 PAIIEVGGIQVKEQPDPLPQDIEQFMENSSQ-GAIFLSFGSNIKSYMVKPEIVGIMFKVLSGLKQ 285
            |.::.:|||.. ....||.|:.|.::..|.: |.:..|.||.:.....|..:.  :...|..:.|
Human   271 PNMVFIGGINC-ANGKPLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMA--IADALGKIPQ 332

  Fly   286 NVIWKWEDLENTPGN-ASNIFYKDWLPQDDILAHPNTKLFVTHAGKGSITESQYHGVPMVALPIF 349
            .|:|::..  ..|.| |:|.....||||:|:|.||.|:.|:||||...:.||..:|||||.:|:|
Human   333 TVLWRYTG--TRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLF 395

  Fly   350 GDHPLNAALMVNSGYGVSLDLQTITEDTFREAINEVLENDKYTQAVRKFSALYRDRPLTPRQSVL 414
            ||...||..|...|.||:|::..:|.:....|:..|:.:..|.:.:.:.|:|::|||:.|....:
Human   396 GDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAV 460

  Fly   415 FWVDYVLRHHGAPNLQSPAVH-MGFVELHNLDIYALVLAILIFLVFLTRLTVKFLFSKLLGKAKV 478
            |||::|:||.|||:|: ||.| :.:.:.|:||:...:||:::.:.|:|.....:.:.|.|||
Human   461 FWVEFVMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGK--- 521

  Fly   479 PARKKK 484
            ..|.||
Human   522 KGRVKK 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C1	NP_525007.1	UDPGT	1..477	CDD:278624	147/517 (28%)
		egt	6..433	CDD:223071	132/467 (28%)
UGT1A4	NP_009051.1	UDPGT	29..525	CDD:278624	147/522 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150617
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.740