Protein Alignment Ugt37C1 and UGT1A9

DIOPT Version :10

• Sequence 1: NP_525007.2
• Gene: Ugt37C1 / 53583
• FlyBaseID: FBgn0026754
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_066307.1
• Gene: UGT1A9 / 54600
• HGNCID: 12541
• Length: 530
• Species: Homo sapiens
• Alignment Length: 530
• Identity: 156/530 - (29%)
• Similarity: 262/530 - (49%)
• Gaps: 36/530 - (6%)

  Fly    11 VWLLAVASPSQGANILGVYSALSPSHLIIHMSTAKALAEAGHNVTVVSMMQPKV---MHKDIHLI 72
            |.||.....::...:|.|  .:..||.....|..:.|...||.|.||   .|:|   :.:.::..
Human    14 VCLLLTCGFAEAGKLLVV--PMDGSHWFTMRSVVEKLILRGHEVVVV---MPEVSWQLGRSLNCT 73

  Fly    73 VVPVTKEQERTLEN---QMASMAGSK-NNIITTMYLLLNG-----LDVMVTSQADLLKDPRF-QR 127
            |  .|.....|||:   :..:.|.:: ...:.::|.||.|     .|:..::...|.||.:. :.
Human    74 V--KTYSTSYTLEDLDREFKAFAHAQWKAQVRSIYSLLMGSYNDIFDLFFSNCRSLFKDKKLVEY 136

  Fly   128 VFETKFDLMILGSFFNDFQLGVAGKLKVPVIVDWMIPSNTMIDEFVANPSEVSYVPNESTFATTP 192
            :.|:.||.:.|..|.| ..|.||....:|.:|.........::|....|:.:||||......:..
Human   137 LKESSFDAVFLDPFDN-CGLIVAKYFSLPSVVFARGILCHYLEEGAQCPAPLSYVPRILLGFSDA 200

  Fly   193 MSFFKRAENLVKHVILKYLTIRFNYKFNRIYNEIFTDKDMPTLSEMKKNISMVFVGSHLISDGPI 257
            |:|.:|..|.:.|:....|..||......|.:||.  :...|..::..:.|:..:.:..:.|.|
Human   201 MTFKERVRNHIMHLEEHLLCHRFFKNALEIASEIL--QTPVTEYDLYSHTSIWLLRTDFVLDYP- 262

  Fly   258 RPLVPAIIEVGGIQVKEQPDPLPQDIEQFMENSSQ-GAIFLSFGSNIKSYMVKPEIVGIMFKVLS 321
            :|::|.:|.:|||.. .|..|||.:.|.::..|.: |.:..|.||.:.....|..:.  :...|.
Human   263 KPVMPNMIFIGGINC-HQGKPLPMEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMA--IADALG 324

  Fly   322 GLKQNVIWKWEDLENTPGN-ASNIFYKDWLPQDDILAHPNTKLFVTHAGKGSITESQYHGVPMVA 385
            .:.|.|:|::..  ..|.| |:|.....||||:|:|.||.|:.|:||||...:.||..:|||||.
Human   325 KIPQTVLWRYTG--TRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVM 387

  Fly   386 LPIFGDHPLNAALMVNSGYGVSLDLQTITEDTFREAINEVLENDKYTQAVRKFSALYRDRPLTPR 450
            :|:|||...||..|...|.||:|::..:|.:....|:..|:.:..|.:.:.:.|:|::|||:.|.
Human   388 MPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPL 452

  Fly   451 QSVLFWVDYVLRHHGAPNLQSPAVH-MGFVELHNLDIYALVLAILIFLVFLTRLTVKFLFSKLLG 514
            ...:|||::|:||.|||:|: ||.| :.:.:.|:||:...:||:::.:.|:|.....:.:.|.||
Human   453 DLAVFWVEFVMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLG 516

  Fly   515 KAKVPARKKK 524
            |   ..|.||
Human   517 K---KGRVKK 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C1	NP_525007.2	Glycosyltransferase_GTB-type	39..517	CDD:471961	146/493 (30%)
UGT1A9	NP_066307.1	UDPGT	26..521	CDD:278624	150/514 (29%)