Protein Alignment Ugt37C1 and UGT1A8

DIOPT Version :9

• Sequence 1: NP_525007.1
• Gene: Ugt37C1 / 53583
• FlyBaseID: FBgn0026754
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_061949.3
• Gene: UGT1A8 / 54576
• HGNCID: 12540
• Length: 530
• Species: Homo sapiens
• Alignment Length: 517
• Identity: 149/517 - (28%)
• Similarity: 247/517 - (47%)
• Gaps: 70/517 - (13%)

  Fly     2 STAKALAEAGHNVTVVSMMQPKV---MHKDIHLIVVPVTKEQERTLEN---QMASMAGS--KNNI 58
            |..:.|...||.|.||   .|:|   :.|.::..|  .|.....|||:   :....|.:  |..:
Human    43 SVVEKLILRGHEVVVV---MPEVSWQLGKSLNCTV--KTYSTSYTLEDLDREFMDFADAQWKAQV 102

  Fly    59 ITTMYLLL---NGLDVMVTSQ----------ADLLKDPRFQRVFETKFDL--MILGSFFN----D 104
            .:...|.|   ||...:..|.          .:.||:..|..||...||.  :|:..:|:    .
Human   103 RSLFSLFLSSSNGFFNLFFSHCRSLFNDRKLVEYLKESSFDAVFLDPFDACGLIVAKYFSLPSVV 167

  Fly   105 FQLGVAGKLKVPVIVDWMIPSNTMIDEFVANPSEVSYVPNESTFATTPMSFFKRAEN----LVKH 165
            |..|:|..               .::|....|:.:||||......:..|:|.:|..|    |.:|
Human   168 FARGIACH---------------YLEEGAQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEH 217

  Fly   166 VILKYLTIRFNYKFNRIYNEIFTDKDMPTLSEMKKNISMVFVGSHLISDGPIRPLVPAIIEVGGI 230
            :..:|    |:.....|.:||.  :...|..::..:.|:..:.:..:.|.| :|::|.:|.:|||
Human   218 LFCQY----FSKNALEIASEIL--QTPVTAYDLYSHTSIWLLRTDFVLDYP-KPVMPNMIFIGGI 275

  Fly   231 QVKEQPDPLPQDIEQFMENSSQ-GAIFLSFGSNIKSYMVKPEIVGIMFKVLSGLKQNVIWKWEDL 294
            .. .|..|||.:.|.::..|.: |.:..|.||.:.....|..:.  :...|..:.|.|:|::..
Human   276 NC-HQGKPLPMEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMA--IADALGKIPQTVLWRYTG- 336

  Fly   295 ENTPGN-ASNIFYKDWLPQDDILAHPNTKLFVTHAGKGSITESQYHGVPMVALPIFGDHPLNAAL 358
             ..|.| |:|.....||||:|:|.||.|:.|:||||...:.||..:|||||.:|:|||...||..
Human   337 -TRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKR 400

  Fly   359 MVNSGYGVSLDLQTITEDTFREAINEVLENDKYTQAVRKFSALYRDRPLTPRQSVLFWVDYVLRH 423
            |...|.||:|::..:|.:....|:..|:.:..|.:.:.:.|:|::|||:.|....:|||::|:||
Human   401 METKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRH 465

  Fly   424 HGAPNLQSPAVH-MGFVELHNLDIYALVLAILIFLVFLTRLTVKFLFSKLLGKAKVPARKKK 484
            .|||:|: ||.| :.:.:.|:||:...:||:::.:.|:|.....:.:.|.|||   ..|.||
Human   466 KGAPHLR-PAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGK---KGRVKK 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C1	NP_525007.1	UDPGT	1..477	CDD:278624	146/508 (29%)
		egt	6..433	CDD:223071	131/459 (29%)
UGT1A8	NP_061949.3	UDPGT	26..521	CDD:278624	146/513 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150391
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.740