DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C1 and Ugt302E1

DIOPT Version :9

Sequence 1:	NP_525007.1	Gene:	Ugt37C1 / 53583	FlyBaseID:	FBgn0026754	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	499	Identity:	166/499 - (33%)
Similarity:	249/499 - (49%)	Gaps:	40/499 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AKALAEAGHNVTVVSMMQPKVMHKDIHLIVVPVTKE--------QERTLENQMASMAGSKNNIIT 60
            ||.||.|||.||:||   |....|.|..|:...|..        :.|.|||      ..|..::.
  Fly    43 AKGLAAAGHEVTLVS---PFPQRKPIKNIIDVETPNIITVMGVYKARILEN------AKKPVLLR 98

  Fly    61 TMYLLLNGLDVMVTSQADLLKDPRFQRVFETK--FDLMILGSFFNDFQLGVAGKLKVPVIVDWMI 123
            ...:.|.|||:    ...|||:|:.|.:.:..  ||.:|..:|.||...|.|.....|:|....:
  Fly    99 YPRISLMGLDI----TESLLKEPKVQELLKQNRTFDGVICETFMNDAHYGFAEHFGAPLITLSSL 159

  Fly   124 PSNTMIDEFVANPSEVSYVPNESTFATTPMSFFKRAENLVKHVILKYLTIRFNY-------KFNR 181
            .:.....:.|..||..||||:........|:|::||:|      |.:....|.|       :...
  Fly   160 GATGWTSDLVGTPSPPSYVPHSLLRFGDRMNFWERAQN------LGFQIYEFAYENLINLPRHEA 218

  Fly   182 IYNEIFTDKDMPTLSEMKKNISMVFVGSHLISDGPIRPLVPAIIEVGGIQV-KEQPDPLPQDIEQ 245
            :|.:.|.: :......|:|:.|:|.:.:|:....| ||..|.:|||||:.| ::.|.||||:|.:
  Fly   219 LYRKYFPN-NKQDFYRMRKDTSLVLLNNHVSISNP-RPYSPNMIEVGGMHVNRKAPKPLPQNIRK 281

  Fly   246 FMENSSQGAIFLSFGSNIKSYMVKPEIVGIMFKVLSGLKQNVIWKWEDLENTPGNASNIFYKDWL 310
            |:|.:..|.|:.|.|||:.|..:.......:.:.|.|||..||||:|: |.......|:...:||
  Fly   282 FIEEAEHGVIYFSLGSNLNSKDLPENKRKAIVETLRGLKYRVIWKYEE-ETFVDKPDNVLISNWL 345

  Fly   311 PQDDILAHPNTKLFVTHAGKGSITESQYHGVPMVALPIFGDHPLNAALMVNSGYGVSLDLQTITE 375
            ||||||||.....|:||.|..|..||.|||.|:|.:|.|||..:|.|.....|||:::....:|.
  Fly   346 PQDDILAHEKVIAFITHGGLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITVKYAQLTA 410

  Fly   376 DTFREAINEVLENDKYTQAVRKFSALYRDRPLTPRQSVLFWVDYVLRHHGAPNLQSPAVHMGFVE 440
            ..||.||..:..:..:|:.|:..|:.|||:..||.:..::||::|.||.||..|:|....:.|::
  Fly   411 SLFRSAIERITSDPSFTERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQ 475

  Fly   441 LHNLDIYALVLAILIFLVFLTRLTVKFLFSKLLGKAKVPARKKK 484
            .||||:.|...:::...|....|.|:||.:.:.|....|:.|.|
  Fly   476 YHNLDVLATFFSVIGLTVIFVFLLVRFLVTIVNGFLYKPSSKLK 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C1	NP_525007.1	UDPGT	1..477	CDD:278624	163/490 (33%)
Ugt37C1	NP_525007.1	egt	6..433	CDD:223071	149/444 (34%)
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	123/358 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445746
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3869
SonicParanoid	1	1.000	-	-		X13
	10	9.880