DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C1 and Ugt35E1

DIOPT Version :9

Sequence 1:	NP_525007.1	Gene:	Ugt37C1 / 53583	FlyBaseID:	FBgn0026754	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster

Alignment Length:	500	Identity:	155/500 - (31%)
Similarity:	255/500 - (51%)	Gaps:	37/500 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KALAEAGHNVTVVSMMQPKVMHKDIHLIVVPVTKEQERTLENQMASMAGSKNNIITTMYLLLNGL 69
            |.||..||.:|.||....:...|:|:.|.||........|..||.:...:......|...:.|
  Fly    43 KNLASLGHEITSVSPFPSEEPVKNIYDIYVPEVLNSFDELLKQMTTPKNTWEFFDATNEFVYN-- 105

  Fly    70 DVMVTSQADLLKDPRFQRVF----ETKFDLMILGSFFNDFQLGVAGKLKVPVI------VDWMIP 124
               :|.  |:..:...:|..    :.:|||:|:..:..|....:|...:.|:|      :||
  Fly   106 ---ITK--DVFNNDGVRREILRPGKAQFDLIIVDIWKYDAFYSLAAYFEAPIIGLAPCGIDW--- 162

  Fly   125 SNTMIDEFVANPSEVSYVPNESTFATTPMSFFKRAENLVKHVILKYLTIRFNY--KFNRIYNEIF 187
               .|||.|.|||.:||:.:.|::.....:|..|..::|: |.:.:....:.|  |...:|.:.|
  Fly   163 ---KIDEMVGNPSPMSYLQSPSSYLYNLDTFGGRVAHVVE-VAISWFNWHWRYEQKHEALYKKYF 223

  Fly   188 TD-KDMPTLSEMKKNISMVFVGSHLISDGPIRPLVPAIIEVGGIQVKEQPDPLPQDIEQFMENSS 251
            .. .:...|||:.::|::|.|..| .:.||.||.||.:|||||:.:.|||..|.||:|.|::.|.
  Fly   224 PKIAETKPLSEISQDIALVLVNQH-FTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSG 287

  Fly   252 Q-GAIFLSFGSNIKSYMVKPEIVGIMFKVLSGLKQNVIWKWED--LENTPGNASNIFYKDWLPQD 313
            : |.|:.|.|:|:::..:..:...|:.:....|.|.|:||:||  |::.|   ||:..:.||||.
  Fly   288 EHGVIYFSLGTNVRTKNMVDDRKRILIEAFGSLPQRVLWKFEDEELQDIP---SNVLVRKWLPQQ 349

  Fly   314 DILAHPNTKLFVTHAGKGSITESQYHGVPMVALPIFGDHPLNAALMVNSGYGVSLDLQTITEDTF 378
            |:||||..|||:||.|..|..||.::|.||:.||.|.|...|...:...|:.:||:...:|.|..
  Fly   350 DLLAHPKVKLFITHGGMQSTIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDEL 414

  Fly   379 REAINEVLENDKYTQAVRKFSALYRDRPLTPRQSVLFWVDYVLRHHGAPNLQSPAVHMGFVELHN 443
            :..|.::|...::....|...|.|||:|:.|.::.::|..|||||.|||:::.....:.|...|:
  Fly   415 KATILQLLTEKRFEVTARIAGARYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHS 479

  Fly   444 LDIYALVLAILIFLVFLTRLTVKF---LFSKLLGKAKVPARKKKQ 485
            ||:...||.:::.::....|.:.|   ..||.:....|..:::||
  Fly   480 LDVLGTVLLVILLVIIAILLIIVFSVCKISKNISTRLVVKKQRKQ 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C1	NP_525007.1	UDPGT	1..477	CDD:278624	152/490 (31%)
Ugt37C1	NP_525007.1	egt	6..433	CDD:223071	141/442 (32%)
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	139/435 (32%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	146/458 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445747
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.850