DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C1 and Ugt35D1

DIOPT Version :9

Sequence 1:	NP_525007.1	Gene:	Ugt37C1 / 53583	FlyBaseID:	FBgn0026754	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	513	Identity:	156/513 - (30%)
Similarity:	258/513 - (50%)	Gaps:	63/513 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KALAEAGHNVTVVSMMQPKVMHKDIHLIVVPVTKEQERTLENQMASMAGSKNN-----------I 58
            |:||..||.:|.||....:...::||.|.||...|.    .|::..:|.:..:           :
  Fly    40 KSLASLGHEITSVSPYPQREPFRNIHDIPVPEVFEN----FNEVLRIASTPRSTWQSSDFINEYV 100

  Fly    59 ITTMYLLLNGLDVMVTSQADLLKDPRFQRVFETKFDLMILGSFFNDFQLGVAGKLKVPVI----- 118
            :.....:||...|    :.|:| .|:     :..|||:|:..:..|...|:|.....|:|
  Fly   101 LNLTKTVLNNEGV----RRDIL-GPQ-----KPHFDLVIMDLWRMDVLSGLAAYFDAPIIGMASY 155

  Fly   119 -VDWMIPSNTMIDEFVANPSEVSYVPNESTFATTPMSFFKRAENLVKHVILKYLTIRFNYKFNRI 182
             .||      .|||.:.|.|.:||:.:.|:......::.:|..:|::.. ..|:    |||:..:
  Fly   156 GTDW------KIDELMGNVSPISYLQSPSSRFYDLEAYGERLLHLMERT-FSYM----NYKWRHV 209

  Fly   183 ------YNEIFTD-KDMPTLSEMKKNISMVFVGSHLISDGPIRPLVPAIIEVGGIQVKEQPDPLP 240
                  |::.|.. .:...|||:.:|..:|.|..| .:.||.||.||.:|:|||:.|....:.|.
  Fly   210 RKQETLYSQFFPSVAERKPLSEISRNFDLVLVNQH-FTLGPPRPYVPNMIQVGGLHVDHSTEALS 273

  Fly   241 QDIEQFMENSSQ-GAIFLSFGSNIKSYMVKPEIVGIMFKVLSGLKQNVIWKWEDLENTPGNASNI 304
            .:::.|::.:.: |.|:.|.|:|:||..:..:...::.:..:.|.|.::||:|| |..||...|:
  Fly   274 AELDHFIQGAGESGVIYFSLGTNVKSKSLSEDRRKVLLETFASLPQRIVWKFED-ELLPGKPPNV 337

  Fly   305 FYKDWLPQDDILAHPNTKLFVTHAGKGSITESQYHGVPMVALPIFGDHPLNAALMVNSGYGVSLD 369
            |...|.||..||||||.|||:||.|..|..||.:||.||:.||...|...|...:...|.|:.|:
  Fly   338 FISKWFPQQAILAHPNVKLFITHGGLLSTIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLN 402

  Fly   370 LQTITEDTFREAINEVLENDKYTQAVRKFSALYRDRPLTPRQSVLFWVDYVLRHHGAPNLQSPAV 434
            ::.:|.:.||..|..:|.|..:.:..|..:|.|||:|:.|.::.::|.:|||.|.||.::|....
  Fly   403 IKQMTSEEFRSTIIRLLTNKSFEETARITAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGK 467

  Fly   435 HMGFVELHNLDIYA-------LVLAILIFLVFLTRLTVKFLFSKLLGKAKVPARKKKQ 485
            .:|||..|:||::.       ::|.|:.:|:.:|  ..|.||  |:.:.|..|.||.|
  Fly   468 DLGFVRYHSLDVFGTFLVGALVILGIVTYLLVMT--LRKCLF--LIKRGKCEAIKKIQ 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C1	NP_525007.1	UDPGT	1..477	CDD:278624	151/503 (30%)
Ugt37C1	NP_525007.1	egt	6..433	CDD:223071	136/451 (30%)
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	136/448 (30%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	151/501 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445750
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.850