DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C1 and Ugt35A1

DIOPT Version :9

Sequence 1:	NP_525007.1	Gene:	Ugt37C1 / 53583	FlyBaseID:	FBgn0026754	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	497	Identity:	158/497 - (31%)
Similarity:	244/497 - (49%)	Gaps:	49/497 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KALAEAGHNVTVVSMM-----QPK---VMHKDIHLIVVPV-TKEQERTLEN-QMASMAGSKNNII 59
            |.||..||||||::..     :|.   :..|.||.|:... ..:..:|... ||.:|.....|::
  Fly    54 KELAHRGHNVTVINTFGSDKNEPNFRVIGAKKIHEIMAAFGNADYTQTASQWQMLTMTTQFLNLL 118

  Fly    60 TTMYLLLNGLDVMVTSQADLLKDPRFQRVFETKFDLMILGSFFNDFQLGVAGKLKVPVIVDWMIP 124
            ||..|    .|..|   .|||....       ||||:|:.:...:...|:........|......
  Fly   119 TTSIL----DDAAV---KDLLNSGE-------KFDLVIMEAVQTEALFGLIQHFGAETIGISSYG 169

  Fly   125 SNTMIDEFVANPSEVSYVPNESTFATTPMSFFKRAENLVKHVILKYLTIRFNYKFNRIYN----- 184
            ::|.|||.:.|.|.:||.|...:..|..|.|..|..|:.:..::        :...||.:
  Fly   170 TDTHIDELMGNISPLSYNPLLLSSRTEQMDFKDRVMNVFEASVM--------WLHKRIVHLPSQR 226

  Fly   185 EIFTDKDMPT----LSEMKKNISMVFVGSHLISDGPIRPLVPAIIEVGG--IQVKEQPDPLPQDI 243
            :::. |..||    |.|:..:.:::.:|.|.....| ||.:|.:|||||  :|.|.:..||.:::
  Fly   227 DLYA-KYFPTARKSLDEVLDSFALMLLGQHFSLSYP-RPYLPNMIEVGGLHLQQKRKVQPLAKEL 289

  Fly   244 EQFMENSSQGAIFLSFGSNIKSYMVKPEIVGIMFKVLSGLKQNVIWKWEDLENTPGNASNIFYKD 308
            .:|:|.|.:|.|:.|.||||||..:.|....::.:..:.:.|.|:||:|| :..|....|:|...
  Fly   290 SEFVEQSEKGVIYFSMGSNIKSKDLPPSTRKMLMQTFASVPQRVLWKFED-DQLPEKPDNVFISK 353

  Fly   309 WLPQDDILAHPNTKLFVTHAGKGSITESQYHGVPMVALPIFGDHPLNAALMVNSGYGVSLDLQTI 373
            |.||.|||||||.|||:||.|..|..||.|.|.|::.||||.|..||.......|||:|.|:.::
  Fly   354 WFPQPDILAHPNVKLFITHGGLLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSV 418

  Fly   374 TEDTFREAINEVLENDKYTQAVRKFSALYRDRPLTPRQSVLFWVDYVLRHHGAPNLQSPAVHMGF 438
            ........|.|:|.|..|..|.:..|.|:||:..|..:..::|.:|||||.||.:|:..:..:.|
  Fly   419 NATELTPLIQELLSNPSYAAAAQTKSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCASRDLDF 483

  Fly   439 VELHNLDIYALVLAILIFLVFLTRLTVKFL---FSKLLGKAK 477
            ::.|.||.:.|::||....:.:..:.:|.|   |..|:.|.:
  Fly   484 IQFHGLDTWGLLIAITFVSLLIVVILIKCLQRVFVSLISKIR 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C1	NP_525007.1	UDPGT	1..477	CDD:278624	158/495 (32%)
Ugt37C1	NP_525007.1	egt	6..433	CDD:223071	145/447 (32%)
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	145/444 (33%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	157/496 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445738
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5496
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	10	9.800