DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C1 and Ugt1a6b

DIOPT Version :9

Sequence 1:	NP_525007.1	Gene:	Ugt37C1 / 53583	FlyBaseID:	FBgn0026754	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_958812.3	Gene:	Ugt1a6b / 394435	MGIID:	3580629	Length:	531	Species:	Mus musculus

Alignment Length:	516	Identity:	151/516 - (29%)
Similarity:	254/516 - (49%)	Gaps:	72/516 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LAEAGHNVTV----VSMMQPKVMHKDIHLIVVPVTKEQERTL-----ENQ-------MASMAGSK 55
            |:|.||::.|    |:::..:..:....:..||.:.|:.:|.     .||       |..:...:
Mouse    49 LSERGHDIVVLVPEVNLLLGESKYYRRKIFSVPYSLEELQTRFRTFGRNQFVPGAPLMGPLREYR 113

  Fly    56 NNIITTMYLLLNGLDVMVTSQADLLKDP---RFQRVFETKFDLMILGSFFND--FQLGVAGKLKV 115
            |:::|        |::..::...||||.   .|.|  |.|||     :.|.|  ...||
Mouse   114 NSMLT--------LEMFFSNCQSLLKDSATLSFLR--ENKFD-----ALFTDPAMPCGV------ 157

  Fly   116 PVIVDWM-IPSNTMIDEFVA--------NPSEVSYVPNESTFATTPMSFFKRAENLVKHVILKYL 171
             ::.::: :||..:...|..        :||.|||||...|..:..|:|.:|..|.:.:::..||
Mouse   158 -ILAEYLNLPSVYLFRGFPCSLEHMLGQSPSPVSYVPRFYTKFSDHMTFPQRLANFIVNILENYL 221

  Fly   172 TIRFNYKFNRIYNEIF-TDKDMPTLSEMKKNISMVFVGSHLISDGPIRPLVPAIIEVGGIQVKEQ 235
            ......|:..|..::. .|..:|:|.:.    |:..:....:.:.| ||::|.:|.:|||..|::
Mouse   222 YYCLYSKYEIIVTDLLKRDVSLPSLHQN----SLWLLRYDFVFEYP-RPIMPNMIFIGGINCKKK 281

  Fly   236 PDPLPQDIEQFMENSSQ-GAIFLSFGSNIKSYMVKP--EIVGIMFKVLSGLKQNVIWKWEDLENT 297
             ..|.|:.|.::..|.: |.:..|.||.:.....|.  ||.    :.|..:.|.|:|::..  ..
Mouse   282 -GKLTQEFEAYVNASGEHGIVVFSLGSMVSEIPEKKAMEIA----EALGRIPQTVLWRYTG--TR 339

  Fly   298 PGN-ASNIFYKDWLPQDDILAHPNTKLFVTHAGKGSITESQYHGVPMVALPIFGDHPLNAALMVN 361
            |.| |.|.....||||:|:|.||.|:.|:||:|...|.|...:|||||.:|:|||...||..|..
Mouse   340 PSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMET 404

  Fly   362 SGYGVSLDLQTITEDTFREAINEVLENDKYTQAVRKFSALYRDRPLTPRQSVLFWVDYVLRHHGA 426
            .|.||:|::..:|.|....|:..|:.|..|.:.:.:.|:|::|||:.|....:|||:||:||.||
Mouse   405 RGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGA 469

  Fly   427 PNLQSPAVH-MGFVELHNLDIYALVLAILIFLVFLTRLTVKFLFSKLL-GKAKVPARKKKQ 485
            |:|: ||.| :.:.:.|:||:...:|||::.:||:......:...|.. ||.:|....|.:
Mouse   470 PHLR-PAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVFKCCAYGCRKCFGGKGRVKKSHKSK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C1	NP_525007.1	UDPGT	1..477	CDD:278624	149/506 (29%)
Ugt37C1	NP_525007.1	egt	6..433	CDD:223071	135/460 (29%)
Ugt1a6b	NP_958812.3	egt	15..503	CDD:223071	145/488 (30%)
Ugt1a6b	NP_958812.3	UDPGT	27..522	CDD:278624	149/507 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840711
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.740