DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C1 and Ugt2b15

DIOPT Version :9

Sequence 1:	NP_525007.1	Gene:	Ugt37C1 / 53583	FlyBaseID:	FBgn0026754	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_695226.3	Gene:	Ugt2b15 / 266685	RGDID:	628623	Length:	530	Species:	Rattus norvegicus

Alignment Length:	498	Identity:	142/498 - (28%)
Similarity:	247/498 - (49%)	Gaps:	45/498 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LAEAGHNVTVVS-----MMQPKVMHKDIHLIVVP--VTKEQERTLENQMASMAG------SKNNI 58
            |.:.||.|||:.     ::.|| ...|:.....|  |:|::   |||....:..      .::..
  Rat    46 LVQRGHEVTVLKPSAYYVLDPK-KSPDLKFETFPTSVSKDE---LENYFIKLVDVWTYELQRDTC 106

  Fly    59 ITTMYLLLNGLDVMVTSQADLLKD-----PRFQRVFETKFDLMILGSFFNDFQLGVAGKLKVPVI 118
            ::...||.|.:|........|.||     ....::.|:|||:::........:| :|..|.:|.:
  Rat   107 LSYSPLLQNMIDGFSDYYLSLCKDTVSNKQLMAKLQESKFDVLLSDPVAACGEL-IAEVLHIPFL 170

  Fly   119 VDWMIPSNTMIDE----FVANPSEVSYVPNESTFATTPMSFFKRAENLVKHVILKYLTIRFN-YK 178
            ..........|::    |:..|   ||||...:....||:|..|.:|::..:...:....|| .|
  Rat   171 YSLRFSPGYKIEKSSGRFILPP---SYVPVILSGMGGPMTFIDRVKNMICTLYFDFWFHMFNAKK 232

  Fly   179 FNRIYNEIFTDKDMP-TLSEMKKNISMVFVGSHLISDGPIRPLVPAIIEVGGIQVKEQPDPLPQD 242
            ::..|:||.   ..| ||:|......|..:.|:...:.| .|.:|.:..:||:|.: .|.|||:|
  Rat   233 WDPFYSEIL---GRPTTLAETMGKAEMWLIRSYWDLEFP-HPTLPNVDYIGGLQCR-PPKPLPKD 292

  Fly   243 IEQFMENSSQ-GAIFLSFGSNIKSYMVKPEIVGIMFKVLSGLKQNVIWKWEDLENTPG--NASNI 304
            :|.|:::|.: |.:..|.||.:.| |.:.:...|.: .|:.:.|.|:||::.  .||.  ..:..
  Rat   293 MEDFVQSSGEHGVVVFSLGSMVSS-MTEEKANAIAW-ALAQIPQKVLWKFDG--KTPATLGPNTR 353

  Fly   305 FYKDWLPQDDILAHPNTKLFVTHAGKGSITESQYHGVPMVALPIFGDHPLNAALMVNSGYGVSLD 369
            .|| ||||:|:|.||.||.||||.|...:.|:.|||:|||.:|:||:...|.|.||..|..|:|:
  Rat   354 VYK-WLPQNDLLGHPKTKAFVTHGGANGVYEAIYHGIPMVGIPMFGEQHDNIAHMVAKGAAVTLN 417

  Fly   370 LQTITEDTFREAINEVLENDKYTQAVRKFSALYRDRPLTPRQSVLFWVDYVLRHHGAPNLQSPAV 434
            ::|:::.....|:.|::.|..|.:.....|.::.|:|:.|....:||:::|:||.||.:|:....
  Rat   418 IRTMSKSDLFNALKEIINNPFYKKNAVWLSTIHHDQPMKPLDKAVFWIEFVMRHKGAKHLRPLGH 482

  Fly   435 HMGFVELHNLDIYALVLAILIFLVFLTRLTVKFLFSKLLGKAK 477
            ::.:.:.|:||:...:|.....:..||..:..|::...:.|.|
  Rat   483 NLPWYQYHSLDVIGFLLTCSAVIAVLTVKSFLFIYRLFVKKEK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C1	NP_525007.1	UDPGT	1..477	CDD:278624	141/496 (28%)
Ugt37C1	NP_525007.1	egt	6..433	CDD:223071	133/452 (29%)
Ugt2b15	NP_695226.3	UDPGT	24..527	CDD:278624	142/498 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344123
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.740