DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37C1 and Ugt8a

DIOPT Version :9

Sequence 1:	NP_525007.1	Gene:	Ugt37C1 / 53583	FlyBaseID:	FBgn0026754	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_035804.2	Gene:	Ugt8a / 22239	MGIID:	109522	Length:	541	Species:	Mus musculus

Alignment Length:	500	Identity:	137/500 - (27%)
Similarity:	246/500 - (49%)	Gaps:	69/500 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AKALAEAGHNVTVVSMMQPKVMHKDIHLIV-----VPVTKEQERTLENQMASMAGSKNNIITTMY 63
            |.||.|.||: ||:.:.:.:.:....|..:     :..:...:..|:::|.::...:...:..:.
Mouse    42 ASALHERGHH-TVLLLSEGRDIAPSNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAVELVD 105

  Fly    64 LL---LNGLDVMVTSQADLLKDPRFQRVFETKFDLM--------------ILGSFFNDFQLGVAG 111
            :|   ....|:||.:||      ..|.:.:.||||:              :||..:..|..|:
Mouse   106 ILDHYTKNCDMMVGNQA------LIQGLKKEKFDLLLVDPNDMCGFVIAHLLGVKYAVFSTGL-- 162

  Fly   112 KLKVPVIVDWMIPSNTMIDEFVANPSEVSYVPNESTFATTPMSFFKRAEN----LVKHVILKYLT 172
                     | .|:.      |..|:.::|||..::..|..|:|.:|.:|    |:..:.:.:|.
Mouse   163 ---------W-YPAE------VGAPAPLAYVPEFNSLLTDRMNFLERMKNTGVYLISRIGVSFLV 211

  Fly   173 IRFNYKFNRI---YNEIFTDKDMPTLSEMKKNISMVFVGSHLISDGPIRPLVPAIIEVGGIQVKE 234
            :.   |:.||   || :...|.|   .::....|:..:.:.:..:.| ||.:|.::.||||..|
Mouse   212 LP---KYERIMQKYN-LLPAKSM---YDLVHGSSLWMLCTDVALEFP-RPTLPNVVYVGGILTK- 267

  Fly   235 QPDPLPQDIEQFMENSSQ-GAIFLSFGSNIKSYMVKPEIVGIMFKVLSGLKQNVIWKWEDLENTP 298
            ...|||:|:::::..:.: |.:.:|||:.:|  .:..:|...:...|..|.|.|||::...:  |
Mouse   268 PASPLPEDLQRWVSGAQEHGFVLVSFGAGVK--YLSEDIANKLAGALGRLPQKVIWRFSGTK--P 328

  Fly   299 GN-ASNIFYKDWLPQDDILAHPNTKLFVTHAGKGSITESQYHGVPMVALPIFGDHPLNAALMVNS 362
            .| .:|....:||||:|:|.|.|.:.|::|.|..||.|:.|||||:|.:|:||||......:...
Mouse   329 KNLGNNTKLIEWLPQNDLLGHSNIRAFLSHGGLNSIFETMYHGVPVVGIPLFGDHYDTMTRVQAK 393

  Fly   363 GYGVSLDLQTITEDTFREAINEVLENDKYTQAVRKFSALYRDRPLTPRQSVLFWVDYVLRHHGAP 427
            |.|:.|:..|:||....:|:.:|:.|..|.|..:|.|.:::|:|..|.....:|:||:|||.||.
Mouse   394 GMGILLEWNTVTEGELYDALVKVINNPSYRQRAQKLSEIHKDQPGHPVNRTTYWIDYILRHDGAR 458

  Fly   428 NLQSPAVHMGFVELHNLDIYALVLAILIFLVFLTRLTVKFLFSKL 472
            :|:|....:.|.:...|||..::|...:.|.|:.....||::.|:
Mouse   459 HLRSAVHQISFCQYFLLDIAFVLLLGAVLLYFILSYVTKFIYRKI 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C1	NP_525007.1	UDPGT	1..477	CDD:278624	137/499 (27%)
Ugt37C1	NP_525007.1	egt	6..433	CDD:223071	126/457 (28%)
Ugt8a	NP_035804.2	UDPGT	21..502	CDD:278624	136/497 (27%)
Ugt8a	NP_035804.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	518..541
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840751
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.740