DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37C1 and ugt-47

DIOPT Version :9

Sequence 1:	NP_525007.1	Gene:	Ugt37C1 / 53583	FlyBaseID:	FBgn0026754	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_505595.2	Gene:	ugt-47 / 187570	WormBaseID:	WBGene00011006	Length:	536	Species:	Caenorhabditis elegans

Alignment Length:	514	Identity:	129/514 - (25%)
Similarity:	226/514 - (43%)	Gaps:	81/514 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AKALAEAGHNVTVVSMMQPKVMHKDIHLIVVPVTKEQ---ERTLENQMASMAGSKNNIIT----- 60
            |..||:||||||::.:        |. |.:|..||..   ::|:......|.|.||.|.:
Worm    43 ADELAKAGHNVTLLEI--------DF-LGIVDSTKSAKLVKKTIVRVPKKMQGFKNVIQSFSEGV 98

  Fly    61 ----TMYLLLNGLDVMVTSQADL-------------LKDPRFQRVFETKFDLMILGSFFNDFQLG 108
                .::.||.|.....|...||             |||..|...|..:.::.   .|.....||
Worm    99 MEDEGLFELLKGNIAYQTVYNDLCEEFLENEVMFNKLKDENFDAFFAEQLNIC---GFGYAKALG 160

  Fly   109 VAGKLKVPVIVDWMIPSNTMIDEFVANPSEVSYVPNESTFATTPMSFFKRAENLVKHVILKYLTI 173
            :..|..:.     ..|..:.:.::.::|:..:.||..|..:..| ::.:|..||::.:.:...
Worm   161 IQRKFLIS-----SCPFFSHVYDYTSHPAPYASVPFISDMSPEP-TYLERTNNLLRGITINTF-- 217

  Fly   174 RFNYKFNRIYNEIFTDK---DMPTLSEMKKNISMVFVGSHLISDGPIRPLVPAIIEVGGIQVKEQ 235
             |.:..||: ..||..|   |.|.::|:.:|:.::|:.:..|.|.. .|.:|.::.|||:.|.:.
Worm   218 -FYFSHNRL-TSIFRKKFGDDFPAITEIVRNVDIIFLATDEIIDFS-SPTLPNLVHVGGLGVDDD 279

  Fly   236 PDPLPQDIEQFMENSSQGAIFLSFGSNIKSYMVKPEIVGIMFKVLSGLKQNVIWKWEDL------ 294
            ...:....|..|:...:|.|:.|.|:...:..:..:::....:::.        |:.|.
Worm   280 TTEMGPVFEAEMKKGDKGVIYFSLGTIANTSTIDKKVMESFLEIVK--------KFPDYHFLIRA 336

  Fly   295 ----ENTPGNA---SNIFYKDWLPQDDILAHPNTKLFVTHAGKGSITESQYHGVPMVALPIFGDH 352
                :||...|   ||:|..|||||..||.||..:.|:||||...:.|:...|||::.:|...|.
Worm   337 DKNDKNTKDKATEISNVFVSDWLPQPAILHHPRLRTFITHAGYNGLMEAALAGVPLITIPFMFDQ 401

  Fly   353 PLNAALMVNSGYGVSLD-LQTITE-DTFREAINEVLENDKYTQAVRKFSALYRDRPLTPRQSVLF 415
            .||:..:...|:|:..| .|.:|| :...|||.|:|.|..||:...:...|.|::|:..|...:.
Worm   402 NLNSRAIEKKGWGIRRDKKQFLTEPNAIEEAIREMLTNPSYTKQAHRVRDLMRNKPMGARDRFIK 466

  Fly   416 WVDYVLRHHGAPNLQSPAVHMGFVELHNLDIYALVLAILIFLVFLTRLTVKFLFSKLLG 474
            ..::|:::.|...|.:....:..::.:||||......:..:.:.       |.|.||.|
Worm   467 TTEWVIQNGGVHELLTEGRDLSIIKYYNLDIIVPCFFVAFYFII-------FPFFKLFG 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C1	NP_525007.1	UDPGT	1..477	CDD:278624	129/514 (25%)
Ugt37C1	NP_525007.1	egt	6..433	CDD:223071	119/469 (25%)
ugt-47	NP_505595.2	UDPGT	23..527	CDD:278624	129/514 (25%)
ugt-47	NP_505595.2	egt	<230..509	CDD:223071	75/287 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	174	1.000	Domainoid score	I2192
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	176	1.000	Inparanoid score	I2693
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14096
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.860