DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37C1 and ugt-33

DIOPT Version :9

Sequence 1:	NP_525007.1	Gene:	Ugt37C1 / 53583	FlyBaseID:	FBgn0026754	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_505692.2	Gene:	ugt-33 / 179464	WormBaseID:	WBGene00007946	Length:	522	Species:	Caenorhabditis elegans

Alignment Length:	511	Identity:	122/511 - (23%)
Similarity:	211/511 - (41%)	Gaps:	86/511 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AKALAEAGHNVTVVSMMQPKVMHKDIHLIVVPVTKEQERTLENQMASMAGSKNNII------TTM 62
            |..|.:||||||   .:.|.|:.|..::..:..||:......::.....|..:|..      .|.
Worm    40 ADTLTDAGHNVT---FLAPIVLRKYENVKYLESTKDIVYIQPSKELEALGFTSNYSKFWTEDATA 101

  Fly    63 YLLLNGLDVMVTSQADLLKDPRFQRVFETKFDLMILGSFFN--------DFQLGVAGKLKVPVIV 119
            ...:..:...|.....|.:|        .|.||.:|....|        :|....|..:...:.:
Worm   102 IQFVPAVRTFVKMFVQLYED--------LKKDLSVLDELKNRNFDAIVFEFLCPTAFPIAEYLGI 158

  Fly   120 DWMIPS-----NTMIDEFVANPSEVSYVPNESTFATTPMSFFKRAENLVKHVILKYLTIRFNYKF 179
            ..::||     :|.:..::..||..:.:|:..:.....|:|::|..|.:..|......
Worm   159 KALLPSLSMTHHTQMSRWIGEPSSPTVLPSMISSFGDDMNFWERLGNTLGDVFFTLFV------- 216

  Fly   180 NRIYNEIFTDKDMPTLS------------EMKKNISMVFVGSHLISDGPIRPLVPAIIEVGGI-- 230
                       |||.::            ||......:|:.|:...| ..||::...:.:|||
Worm   217 -----------DMPRMTSFSDPERKIDFYEMSVRAPFMFMNSNPYLD-YARPILTKTVLIGGISV 269

  Fly   231 ---QVKEQPDPLPQDIEQFMENSSQGAIFLSFGSNIKSYMVKPEIVGIMFKVLSGLKQNV--IWK 290
               |:|::  .|.:..::.:....|. |.:||||.|.|..:.......:.:|:... .||  |||
Worm   270 NVTQLKQK--KLNEKYDKIISERQQN-ILISFGSMIFSKDMPDVYKNTLVQVIKSF-PNVTFIWK 330

  Fly   291 WED-----LENTPGNASNIFYKDWLPQDDILAHPNTKLFVTHAGKGSITESQYHGVPMVALPIFG 350
            :|:     .::.|    |:.:..|:||..:||......||||||.||:||..|.|.|.|.:|:|.
Worm   331 YEEDDVSFAKHLP----NLHFSKWVPQTALLADSRLSAFVTHAGLGSVTELSYMGKPAVLIPLFA 391

  Fly   351 DHPLNAALMVNSGYGVSL---DLQTITEDTFREAINEVLENDKYTQAVRKFSALYRDRPLTPRQS 412
            |...|:..:......::|   ||.:.  :..|.|||.:|.:::|.......|...:|:|::|...
Worm   392 DQLRNSKTLSRHNGSITLSKYDLSSF--EKLRFAINTILNDERYKINAEILSQQLQDQPVSPHAL 454

  Fly   413 VLFWVDYVLRHHGAPNLQSPAVHMGFVELHNLDIYALVLAILIFLVFLTRLTVKFL 468
            ::...::..::...|||...:..|.|:..:.|||...|..|||.......||||::
Worm   455 LVKHAEFGAKYGELPNLDPCSRQMSFISFYMLDIIVFVGFILITTTIGIVLTVKWI 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C1	NP_525007.1	UDPGT	1..477	CDD:278624	122/511 (24%)
Ugt37C1	NP_525007.1	egt	6..433	CDD:223071	108/472 (23%)
ugt-33	NP_505692.2	Glycosyltransferase_GTB_type	1..498	CDD:299143	117/497 (24%)
ugt-33	NP_505692.2	UDPGT	31..520	CDD:278624	122/511 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14625
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3869
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.840