DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C1 and ugt-49

DIOPT Version :9

Sequence 1:	NP_525007.1	Gene:	Ugt37C1 / 53583	FlyBaseID:	FBgn0026754	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_505666.2	Gene:	ugt-49 / 179446	WormBaseID:	WBGene00007070	Length:	525	Species:	Caenorhabditis elegans

Alignment Length:	536	Identity:	129/536 - (24%)
Similarity:	208/536 - (38%)	Gaps:	106/536 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AKALAEAGHNVTV-VSMMQPKVMHKDIHLIVVPVTKEQERTLENQMASMAGSKNNIITTM----- 62
            |.||.:|||:|.: ::..:|              ..|...|.:.::.:|.|........|
Worm    38 ADALVDAGHDVVMFITEYEP--------------LTEFTGTKKAKVITMKGFSTKFAEDMDGIGE 88

  Fly    63 YLL-----------------LNGLDVMVTSQADL--LKDPRFQRVFETKFDLMILGSFFNDFQLG 108
            |||                 ....|.::|.:.:|  |:...|...|..:.||..:|..   ..||
Worm    89 YLLSSSRLSFLERLMFEKTCTGACDDLMTRREELEQLRAYNFDVAFSEQIDLCGVGIV---RYLG 150

  Fly   109 VAGKLKVPVIVDWMIPSNTMIDEFVAN---PSEVSYVPN-ESTFATTPMSFFKRAENLVKHV--- 166
            :...|       | |.:..::|....|   |:..||||. |.......|.|::|..||...:
Worm   151 IKNHL-------W-ISTTPIMDAVSYNLGIPAPSSYVPTIEENDNGDKMDFWQRTFNLYMKIGSI 207

  Fly   167 -ILKYLTIRFNYKFNRIYNEIFTDKDMPTLSEMKKNISMVFVGSHLISDGPIRPLVPAIIEVGGI 230
             |.:|.|......|.:..      .|.|.:.|:..|.|:.||.|..:.|.| ||.:...|.|||:
Worm   208 LIHRYGTDGTTEVFRKYI------PDFPNVREIAANSSLCFVNSDEVLDLP-RPTITKAIYVGGL 265

  Fly   231 QVKEQPDPLPQDIEQFMENSSQGAIFLSFGSNI---------KSYMVK--PEIVGIMF------- 277
            .:.:...||.:.....|....:|.:.:|.||.|         |..:::  .||....|
Worm   266 GIPKVSKPLDKKFTNIMSKGKEGVVIISLGSIIPFGDLPAAAKEGVLRAIQEISDYHFLIKIAKG 330

  Fly   278 -----KVLSGLKQNVIWKWEDLENTPGNASNIFYKDWLPQDDILAHPNTKLFVTHAGKGSITESQ 337
                 |::.|:|                  |:...:||||.|||:||..||||.|.|...:.|:.
Worm   331 DNNTKKLVEGIK------------------NVDVAEWLPQVDILSHPRLKLFVMHGGINGLVETA 377

  Fly   338 YHGVPMVALPIFGDHPLNAALMVNSGYGVSLDLQTITEDTFREAINEVLENDKYTQAVRKFSALY 402
            ...||.|.:|:|.|...|..::...|.|..|....|..::|:..:..||....|.:...:...:.
Worm   378 IQAVPTVIVPVFADQFRNGRMVEKRGIGKVLLKLDIGYESFKNTVLTVLNTPSYKKNAIRIGKMM 442

  Fly   403 RDRPLTPRQSVLFWVDYVLRHHGAPNLQSPAVHMGFVELHNLDIYALVLAILIFLVFLTRLTVKF 467
            ||:|.:|.:.:..|..:.:.|.....|......:..:..:|||:.|.||.:.:.::.:.....||
Worm   443 RDKPFSPEERLTKWTQFAIDHGVLEELHVEGSRLNTIIYYNLDVIAFVLFVFVAVLHVFIYAFKF 507

  Fly   468 LFSKLLGKAKVPARKK 483
            |..|...::.:...||
Worm   508 LCCKKRSQSNIKKSKK 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C1	NP_525007.1	UDPGT	1..477	CDD:278624	127/528 (24%)
Ugt37C1	NP_525007.1	egt	6..433	CDD:223071	116/482 (24%)
ugt-49	NP_505666.2	UDPGT	17..523	CDD:278624	127/534 (24%)
ugt-49	NP_505666.2	egt	<162..464	CDD:223071	85/326 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	174	1.000	Domainoid score	I2192
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	176	1.000	Inparanoid score	I2693
Isobase	1	0.950	-	0	Normalized mean entropy	S5496
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14680
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.810