DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37C1 and ugt-48

DIOPT Version :9

Sequence 1:	NP_525007.1	Gene:	Ugt37C1 / 53583	FlyBaseID:	FBgn0026754	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_504464.2	Gene:	ugt-48 / 178940	WormBaseID:	WBGene00015965	Length:	526	Species:	Caenorhabditis elegans

Alignment Length:	499	Identity:	128/499 - (25%)
Similarity:	221/499 - (44%)	Gaps:	73/499 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AKALAEAGHNVTVVSMMQPKVMHKDIHLIVV------PVT---KEQERTLENQMASMAGSKNNII 59
            |..||.|||.|.   ..:|..::.....:..      |||   ..:.:.::|.::.....:::|.
Worm    39 ADELANAGHEVV---NFEPDFLNLTDKFVPCKKCRRWPVTGLNNYKFKKIQNGLSGDVFQQSSIW 100

  Fly    60 TTMY---------LLLNGLDVMVTSQ--ADLLKDPRFQRVFETKFDLMILGSFFNDFQLGVAGKL 113
            :.::         ...|..:.|||::  .:.||..:|...|..:..|..:|.   ...:|:..:.
Worm   101 SKIFNTDSDPYQDEYTNMCEEMVTNKELIEKLKKEKFDAYFGEQIHLCGMGL---AHLIGIKHRF 162

  Fly   114 KVPVIVDWMIPSNTM---IDEFVANPSEVSYVPNESTFATTPMSFFKRAENLVKHVILKYLTIRF 175
                   | |.|.||   :.:.:..|:..|.:|..||...||..|::||:|.|    |:...||.
Worm   163 -------W-IASCTMSVSMRDSLGIPTPSSLIPFMSTLDATPAPFWQRAKNFV----LQMAHIRD 215

  Fly   176 NYKFNRIYNEIFT---DKDMPTLSEMKKNISMVFVGSHLISDGPIR-PLVPAIIEVGGIQVKEQP 236
            .|:...:.|::|.   ..|.|.:..:.|...::||.:..:.:  |: |.:..::.:||:.:..:.
Worm   216 EYRDVVLTNDMFKKNFGSDFPCVEFLAKTSDLIFVSTDELLE--IQAPTLSNVVHIGGLGLSSEG 278

  Fly   237 DPLPQDIEQFMENSSQGAIFLSFGSNIKSYMVKPEIVGIMFKVLSGLKQNVIWKWEDLE------ 295
            ..|.:...:.|| ..:|.|..|.|:...:..:.|.|:..:.|:..        |::|.|
Worm   279 GGLDEKFVKIME-KGKGVILFSLGTIANTTNLPPTIMENLMKITQ--------KFKDYEFIIKVD 334

  Fly   296 -------NTPGNASNIFYKDWLPQDDILAHPNTKLFVTHAGKGSITESQYHGVPMVALPIFGDHP 353
                   :.....||:...||:||..:||||..|.|:||||..|:.||.|.|||::.:|...|.|
Worm   335 KFDRRSFDLAEGLSNVLVVDWVPQTAVLAHPRLKAFITHAGYNSLMESAYAGVPVILIPFMFDQP 399

  Fly   354 LNAALMVNSGYGVSLD-LQTITE-DTFREAINEVLENDKYTQAVRKFSALYRDRPLTPRQSVLFW 416
            .|...:...|:|:..| .|.|.: |....||.|:|.|..|.:...:...|.|.:|.:..:.::..
Worm   400 RNGRSVERKGWGILRDRFQLIKDPDAIEGAIKEILVNPTYQEKANRLKKLMRSKPQSASERLVKM 464

  Fly   417 VDYVLRHHGAPNLQSPAVHMGFVELHNLDIY--ALVLAILIFLV 458
            .::||.:.|...||....||.|...:||||.  |..:.:|||:|
Worm   465 TNWVLENDGVEELQYEGKHMDFFTFYNLDIIITAASIPVLIFIV 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C1	NP_525007.1	UDPGT	1..477	CDD:278624	128/499 (26%)
Ugt37C1	NP_525007.1	egt	6..433	CDD:223071	115/468 (25%)
ugt-48	NP_504464.2	UDPGT	19..510	CDD:278624	128/499 (26%)
ugt-48	NP_504464.2	egt	<224..471	CDD:223071	68/257 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	174	1.000	Domainoid score	I2192
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	176	1.000	Inparanoid score	I2693
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.860