Protein Alignment Ugt37C1 and UGT2A1

DIOPT Version :9

• Sequence 1: NP_525007.1
• Gene: Ugt37C1 / 53583
• FlyBaseID: FBgn0026754
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_001376494.1
• Gene: UGT2A1 / 10941
• HGNCID: 12542
• Length: 737
• Species: Homo sapiens
• Alignment Length: 500
• Identity: 137/500 - (27%)
• Similarity: 252/500 - (50%)
• Gaps: 36/500 - (7%)

  Fly     7 LAEAGHNVTVVSMMQPKVMHKD----IHLIVVPVTKEQ---ERTLENQMASMAGSKNNIIT--TM 62
            |.:..|||||::......::.:    ::..|:||:.::   :..:|:.:......:...:|  ..
Human   253 LIQRNHNVTVLASSATLFINSNPDSPVNFEVIPVSYKKSNIDSLIEHMIMLWIDHRPTPLTIWAF 317

  Fly    63 Y-----LLLNGLDVMVTSQADLLKDPRFQ-RVFETKFDLMILG--SFFNDFQLGVAGKLKVPVIV 119
            |     ||.....:.:.....:||:|:.. |:.:..||:::..  :...|.   ||.||.:|.:.
Human   318 YKELGKLLDTFFQINIQLCDGVLKNPKLMARLQKGGFDVLVADPVTICGDL---VALKLGIPFMY 379

  Fly   120 DWMI-PSNTMIDEFVANPSEVSYVPNESTFATTPMSFFKRAENLVKHVILKYLTIRFNYKFNRIY 183
            .... |::|:.......|:.|||||...:..|..|:|.:|.:|.:.:.:..|:...:..::|..|
Human   380 TLRFSPASTVERHCGKIPAPVSYVPAALSELTDQMTFGERIKNTISYSLQDYIFQSYWGEWNSYY 444

  Fly   184 NEIFTDKDMP-TLSEMKKNISMVFVGSHLISDGPIRPLVPAIIEVGGIQVKEQPDPLPQDIEQFM 247
            ::|.   ..| ||.|......:..:.::...:.| ||.:|....|||:..| ...|||:::|:|:
Human   445 SKIL---GRPTTLCETMGKAEIWLIRTYWDFEFP-RPYLPNFEFVGGLHCK-PAKPLPKEMEEFI 504

  Fly   248 ENSSQ-GAIFLSFGSNIKSYMVKPEIVGIMFKVLSGLKQNVIWKWEDLE-NTPGNASNIFYKDWL 310
            ::|.: |.:..|.||.:|:  :..|...::...|:.:.|.|:|:::..: .|.||.:.:|  ||:
Human   505 QSSGKNGVVVFSLGSMVKN--LTEEKANLIASALAQIPQKVLWRYKGKKPATLGNNTQLF--DWI 565

  Fly   311 PQDDILAHPNTKLFVTHAGKGSITESQYHGVPMVALPIFGDHPLNAALMVNSGYGVSLDLQTITE 375
            ||:|:|.||.||.|:||.|...|.|:.|||||||.:|:|.|.|.|.|.|...|..|.::|.|:|.
Human   566 PQNDLLGHPKTKAFITHGGTNGIYEAIYHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTS 630

  Fly   376 DTFREAINEVLENDKYTQAVRKFSALYRDRPLTPRQSVLFWVDYVLRHHGAPNLQSPAVHMGFVE 440
            .....|:..|:....|.:...:.|.::.|:|:.|....:||:::|:||.||.:|:..|..:.:.:
Human   631 VDLLSALRTVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQ 695

  Fly   441 LHNLDIYALVLAILIFLVFLTRLTVKFLFSKLLGKAKVPARKKKQ 485
            .|:||:...:|..:...:||......|...|.   .|:..:||::
Human   696 YHSLDVIGFLLVCVTTAIFLVIQCCLFSCQKF---GKIGKKKKRE 737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C1	NP_525007.1	UDPGT	1..477	CDD:278624	134/490 (27%)
		egt	6..433	CDD:223071	125/446 (28%)
UGT2A1	NP_001376494.1	UDPGT	237..725	CDD:278624	133/483 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150211
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.740