DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C1 and ugt2b5

DIOPT Version :9

Sequence 1:	NP_525007.1	Gene:	Ugt37C1 / 53583	FlyBaseID:	FBgn0026754	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_001170816.2	Gene:	ugt2b5 / 100384902	ZFINID:	ZDB-GENE-100402-3	Length:	527	Species:	Danio rerio

Alignment Length:	500	Identity:	131/500 - (26%)
Similarity:	244/500 - (48%)	Gaps:	37/500 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LAEAGHNVTVV---SMMQPKVMHKD----IHLIVVPVTKEQERTLENQMA-SMAGSKNNIITTMY 63
            |.:.||||||:   ..:..|....|    .|..|....::.:...:..|. |:....|:....:.
Zfish    42 LLDRGHNVTVLVPDGALFMKAKESDRFSYQHFSVSKSAQDMQDFFDELMRFSVFEMDNSSFLEIQ 106

  Fly    64 LLLNGL-----DVMVTSQADLLKDPR-FQRVFETKFDLMILGSFF--NDFQLGVAGKLKVPVIVD 120
            :....|     |:.::....:||.|. ..::.:.|||:::....:  :|.   ||.:|.||::..
Zfish   107 MKFFNLGSQHQDMSLSYCDGILKSPELMDKLKKGKFDVVLSDPMYPCSDI---VAEELNVPLVYT 168

  Fly   121 WMI----PSNTMIDEFVANPSEVSYVPNESTFATTPMSFFKRAENLVKHVILKYLTIRFNYKFNR 181
            :..    .:..|..:..|.|   ||||...:..|..|||.:|..|::.::....|:.....:|:.
Zfish   169 FRFSVAHAAERMCGQIPAPP---SYVPGAMSKLTDKMSFTERIFNMLFYLSQDTLSRLIWRRFDN 230

  Fly   182 IYNEIFTDKDMPTLSEMKKNISMVFVGSHLISDGPIRPLVPAIIEVGGIQVKEQPDPLPQDIEQF 246
            .|.|.|...  .:..||.....:..:.::...:.| ||.||....:||:.. ....|||:|:|:|
Zfish   231 YYTEYFGRS--TSYCEMMGKADIWLIRTYWDFEFP-RPFVPNFKYIGGLHC-TPAKPLPKDMEEF 291

  Fly   247 MENS-SQGAIFLSFGSNIKSYMVKPEIVGIMFKVLSGLKQNVIWKW-EDLENTPGNASNIFYKDW 309
            :::| ..|.:..:.||.|..  |..|:...:...|:.:.|.|:|:: .:..:|.|..:.| || |
Zfish   292 VQSSGDDGIVVFTLGSMIDK--VPKEMSNRIASALAQIPQKVLWRYGGEKPDTLGENTRI-YK-W 352

  Fly   310 LPQDDILAHPNTKLFVTHAGKGSITESQYHGVPMVALPIFGDHPLNAALMVNSGYGVSLD-LQTI 373
            :||:|:|.||.|:.|:||.|...:.|:.|||||||.:|:|||.|.|...|......|.:| ::::
Zfish   353 IPQNDLLGHPKTRAFITHGGTNGVYEAIYHGVPMVGIPLFGDQPDNMVHMTTRAAAVVVDSIKSM 417

  Fly   374 TEDTFREAINEVLENDKYTQAVRKFSALYRDRPLTPRQSVLFWVDYVLRHHGAPNLQSPAVHMGF 438
            ......:.:|.|:.:..|.:...:.|.::.|||:.|....:||:::|:|:.||.:|:..|.::.:
Zfish   418 QPQELVDKLNTVINDPSYKENAMRLSRIHHDRPMKPLDESVFWIEFVMRNKGAKHLRVEAHNLTW 482

  Fly   439 VELHNLDIYALVLAILIFLVFLTRLTVKFLFSKLLGKAKVPARKK 483
            .:.|.||::|.:..:|..::::.....||...:...::|..::|:
Zfish   483 YQYHCLDVFAFLTTVLTLVLYICFKMAKFFIMRCCFRSKRKSKKE 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C1	NP_525007.1	UDPGT	1..477	CDD:278624	129/492 (26%)
Ugt37C1	NP_525007.1	egt	6..433	CDD:223071	121/448 (27%)
ugt2b5	NP_001170816.2	UDPGT	20..523	CDD:278624	130/494 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.810