DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C1 and ugt5e1

DIOPT Version :9

Sequence 1:	NP_525007.1	Gene:	Ugt37C1 / 53583	FlyBaseID:	FBgn0026754	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	XP_005166829.1	Gene:	ugt5e1 / 100002993	ZFINID:	ZDB-GENE-081105-106	Length:	590	Species:	Danio rerio

Alignment Length:	516	Identity:	147/516 - (28%)
Similarity:	252/516 - (48%)	Gaps:	76/516 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LAEAGHNVTVV-SMMQPKVMHKDIHLIVVPVTKEQERTLEN--QMASM----------AGSKNNI 58
            |.:.||.:||| |.....:.....|...:.:......:||:  .|||.          .||..:.
Zfish   104 LHQRGHKLTVVRSANSWYIPENATHYTSITIQVNHLSSLEDPKYMASFLKRNIDIQRGKGSIWSF 168

  Fly    59 ITTMYLLLNGLDVMVTSQADL----LKDPRFQRVF-ETKFDLM----------ILGSFFNDFQLG 108
            :.....::..|:....|.|::    |:|.:..:.. |:|:|||          |||::
Zfish   169 LALQKEIITLLEESHRSTAEMVRVVLEDEKLIKTLKESKYDLMLTDPGFAGGVILGAY------- 226

  Fly   109 VAGKLKVPVI--VDWMIPSNTMIDEFVANPSEVSYVPNESTFATTPMSFFKRAENLVKHVILKYL 171
                |.:|::  |.|:..:.   ..|...||.:||:|...:..|..|||..:.:|::...|.:|:
Zfish   227 ----LGLPMVFNVRWITNAE---GHFAIAPSPLSYIPTIGSRVTDKMSFANKLKNIMHFGIGQYI 284

  Fly   172 TIRFNYKFNR-IYNEIFTDKDMPTLSEMKKNISMVFVGSHL-------ISDGPIRPLVPAIIEVG 228
                ::...| :|..:.:....|     ..|:..:..|:.|       :.:.| ||.:|.::.:|
Zfish   285 ----DHMLTRPLYQGVISKYIDP-----NTNVYALIQGADLWLMRVDFVFEFP-RPTMPNVVYIG 339

  Fly   229 GIQVKEQPDPLPQDIEQFMENSSQ-GAIFLSFGSNIKSYMVKPEIVGIMFKVLSGLKQNVIWKW- 291
            |.|.|.. .|||.::.:|:|:|.: |.:.:|.|:.:.|.:  |:|..|:....:.|.|.|||:.
Zfish   340 GFQCKPS-KPLPDELNKFVESSGEHGVVIMSLGTLLGSLV--PDISEIVASAFAQLPQKVIWRHV 401

  Fly   292 EDLENTPGNASNIFYKDWLPQDDILAHPNTKLFVTHAGKGSITESQYHGVPMVALPIFGDHPLNA 356
            .:..:|.||  |....|||||:|:|.||.||.||||.|...|.|:.||||||:.||:..|...|.
Zfish   402 GEKPSTLGN--NTLVVDWLPQNDLLGHPKTKAFVTHGGTNGIYEAIYHGVPMLGLPLIFDQFDNI 464

  Fly   357 ALMVNSGYGVSLDLQTITEDTFREAINEVL-ENDKYTQAVRKFSALYRDRPLTPRQSVLFWVDYV 420
            ..:...|....||:.|:..|...:|:.::| |...|.:.:||.|:|:||.||.|..|.:||:::|
Zfish   465 IRLEARGVARMLDVATLDVDILTQALKDILDEKQSYQKNMRKMSSLHRDTPLKPLDSAIFWLEFV 529

  Fly   421 LRHHGAPNLQSPAVHMGFVELHNLDIYALVLAIL----IFLVFLTRLTVKFLFSKLLGKAK 477
            :||.||.:|::.:..:.:...|.||:.||::::.    :.|:.::|..::....|:  |||
Zfish   530 MRHKGAAHLRTESYKLPWYSYHCLDVLALIMSLCTAAGLLLILISRALLRACVRKI--KAK 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C1	NP_525007.1	UDPGT	1..477	CDD:278624	145/514 (28%)
Ugt37C1	NP_525007.1	egt	6..433	CDD:223071	136/466 (29%)
ugt5e1	XP_005166829.1	UDPGT	82..586	CDD:278624	144/512 (28%)
ugt5e1	XP_005166829.1	egt	<324..550	CDD:223071	85/231 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584418
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.740