Protein Alignment Gclc and GCLC

DIOPT Version :9

• Sequence 1: NP_001285001.1
• Gene: Gclc / 53581
• FlyBaseID: FBgn0040319
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: NP_001489.1
• Gene: GCLC / 2729
• HGNCID: 4311
• Length: 637
• Species: Homo sapiens
• Alignment Length: 709
• Identity: 379/709 - (53%)
• Similarity: 482/709 - (67%)
• Gaps: 89/709 - (12%)

  Fly     1 MGLLSEGSPLSWEETKALADHVREHGVNQFINLYHRLKDRQGDILKWGDEVEYIIVKFDDEQKVA 65
            |||||:||||||||||..|||||.||:.||:::||.:|||..|:|||||||||::|.||.|.|..
Human     1 MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKV 65

  Fly    66 RVALRAQDLLAQLNEK-ELADPNGVKSLWRPEYGAYMIEGTPGKPFGGLMAHFNLVEANMRYRRE 129
            |:.|..:.:|..|.|| |..:||. .:|||||||:||||||||:|:||.|:.||.||||||.||:
Human    66 RLVLSGEKVLETLQEKGERTNPNH-PTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRK 129

  Fly   130 EVTELLAKDECVMSITNFPRLGAPNFTYPLAQPRPEDPLSSARSLYFPDEAIFPGHPRFKTLTRN 194
            |.|.:|.:::.:.:||:|||||.|.||.|..:|.|.:. .:::||:|||||| ..||||.|||||
Human   130 EATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEG-GASKSLFFPDEAI-NKHPRFSTLTRN 192

  Fly   195 IRKRRGEKVSIKLKVFKDTKTKLPV--------EGAPPGEPDVVLLDAMGFGMGCCCLQLTFQAC 251
            ||.||||||.|.:.:|||..|..|.        |.:...:||.:.:||||||||.||||:|||||
Human   193 IRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQAC 257

  Fly   252 NITEARRLYDQLAPLCPIMLALTAASPIYRGYLTESDCRWNVISSSVDCRTEEERGLAPLDQQKF 316
            :|:|||.||||||.:|||::||:||||.||||:::.||||.|||:|||.||.|||||.||....:
Human   258 SISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNY 322

  Fly   317 RIAKSRYDSIDSYLSPEGAKYNDVPLTYDEKVYQRLVEGGIDHLLAQHVAHLFIRDTVSLFSEKV 381
            ||:||||||||||||..|.||||:.||.|:::|::|::.|||||||||||||||||.::||.||:
Human   323 RISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKI 387

  Fly   382 HQNDNEDTDHFENIQSTNWQTMRFKPPPPNSSIGWRVEFRPCEAQISDFENAAIVCFVVLLTRVI 446
            |.:|..::|||||||||||||||||||||||.|||||||||.|.|::||||:|.|.|||||||||
Human   388 HLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVI 452

  Fly   447 LSYQLNFLTPISKVDENMQTAQKRDACRKEKFWFRKSSKTTEQRAAKAQAQAQAQAKAQAQTNGK 511
            |||:|:||.|:|||||||:.||||||..:..|:|||.
Human   453 LSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKD---------------------------- 489

  Fly   512 ATLNGNGLANGNGNGSENSDQEEQQPLTNGSAKMNGHGSGTTNGTNGSSNGSSNGTDSDHTDTDD 576
            ....||.:.:|.|. ::||                                         |:...
Human   490 ICKGGNAVVDGCGK-AQNS-----------------------------------------TELAA 512

  Fly   577 EENELFQLLSINEIFNGKPNVFPGLVPLIRSYLQSMEVDTDTHCTIEQYLRFIQKRAAGELITTA 641
            ||   :.|:||:.|.|||..|||||:|::.|||::||||.||.|:|..||:.|:|||:|||:|.|
Human   513 EE---YTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVA 574

  Fly   642 TWMREQVLSHPDYKQDSVVSERINYDLLKRIQGIQEGKQVEPALLGQDY----HSKTKT 696
            .||||.:.:|||||||||:::.:||.|:.:...|.......|.|||..:    :|.:||
Human   575 RWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKT 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gclc	NP_001285001.1	GCS	232..675	CDD:281119	239/442 (54%)
GCLC	NP_001489.1	RpsA	<22..76	CDD:333073	28/53 (53%)
		GCS	236..608	CDD:308610	239/444 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154959
Domainoid	1	1.000	383	1.000	Domainoid score	I828
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1148
Inparanoid	1	1.050	638	1.000	Inparanoid score	I824
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54052
OrthoDB	1	1.010	-	-		D126317at33208
OrthoFinder	1	1.000	-	-		FOG0005562
OrthoInspector	1	1.000	-	-		oto89525
orthoMCL	1	0.900	-	-		OOG6_102076
Panther	1	1.100	-	-	LDO	PTHR11164
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R527
SonicParanoid	1	1.000	-	-		X3981
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.940