DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PLS3 and Fim

DIOPT Version :9

Sequence 1:NP_001129497.1 Gene:PLS3 / 5358 HGNCID:9091 Length:630 Species:Homo sapiens
Sequence 2:NP_728074.1 Gene:Fim / 32721 FlyBaseID:FBgn0024238 Length:641 Species:Drosophila melanogaster


Alignment Length:637 Identity:341/637 - (53%)
Similarity:433/637 - (67%) Gaps:40/637 - (6%)


- Green bases have known domain annotations that are detailed below.


Human     1 MDEMATTQISKDELDELKEAFAKVDLNSNGFICDYELHELFKEANMPLPGYKVREIIQKLMLDGD 65
            :::..|.|..|..|:||   ...:|.|.:|||..:||.:...:....|.||:|||     |:|..
  Fly     7 VEQHQTVQEFKQNLEEL---IPNLDANKDGFIDLHELKDALNQVGFKLAGYQVRE-----MIDEY 63

Human    66 RNK-----DGKISFDEFVYIFQEVKSSDIAKTFRKAINRKEGICALGGTSELSSEGTQHSYSEEE 125
            :.|     .||::.:||..:..::||.|:|.||:..:::||.:..|||.|.:|||||.||...||
  Fly    64 KGKQLTAFQGKLNLEEFEALCLDLKSKDVASTFKTVVSKKENLETLGGMSSISSEGTTHSVRLEE 128

Human   126 KYAFVNWINKALENDPDCRHVIPMNPNTDDLFKAVGDGIVLCKMINLSVPDTIDERAINKKKLTP 190
            :.||.:|||..|.:|.|.:|::|::.....|:.::.|||:|||:||.|.||||||||||||.||.
  Fly   129 QLAFSDWINSNLGHDKDLQHLLPIDSEGKRLYLSIKDGILLCKIINHSCPDTIDERAINKKNLTV 193

Human   191 FIIQENLNLALNSASAIGCHVVNIGAEDLRAGKPHLVLGLLWQIIKIGLFADIELSRNEALAALL 255
            :...|||.|||.|:.||||::|||.|.||..||||||||||||||:||||:.|.|.....||.||
  Fly   194 YREFENLTLALVSSQAIGCNIVNIDAHDLAKGKPHLVLGLLWQIIRIGLFSHITLDSCPGLAGLL 258

Human   256 RDGETLEELMKLSPEELLLRWANFHLENSG-WQKINNFSADIKDSKAYFHLLNQIAPKGQKEGEP 319
            .|.|.||:|||:|||.:||||.|.|||.:| .::..||.:||.||:.|.|||.|||...      
  Fly   259 FDNERLEDLMKMSPEAILLRWVNHHLERAGISRRCTNFQSDIVDSEIYSHLLKQIAGND------ 317

Human   320 RIDINMSGFNETDDLKRAESMLQQADKLGCRQFVTPADVVSGNPKLNLAFVANLFNKYPALTKPE 384
             .|:|:....|:|...|||.|||||.||.||.|:||.|||:|..||||||||||||.:|.|.|||
  Fly   318 -ADVNLDALRESDLQSRAEIMLQQAAKLNCRSFLTPQDVVNGVYKLNLAFVANLFNNHPGLDKPE 381

Human   385 NQDIDWTLLEG-----ETREERTFRNWMNSLGVNPHVNHLYADLQDALVILQLYERIKVP--VDW 442
            .       :||     |||||:|:||||||:||.||||.||:||.|.|||.||::.|| |  |:|
  Fly   382 Q-------IEGLESIEETREEKTYRNWMNSMGVAPHVNWLYSDLADGLVIFQLFDVIK-PGIVNW 438

Human   443 SKVNKPPYPKLGANMKKLENCNYAVELGKHPAKFSLVGIGGQDLNDGNQTLTLALVWQLMRRYTL 507
            |:|:| .:..|...|:|||||||||:|||. .|||||||.||||||||.||||||:|||||.|||
  Fly   439 SRVHK-RFSPLRKFMEKLENCNYAVDLGKQ-LKFSLVGIAGQDLNDGNATLTLALIWQLMRAYTL 501

Human   508 NVLEDLGD-GQKANDDIIVNWVNRTLSEAGKSTSIQSFKDKTISSSLAVVDLIDAIQPGCINYDL 571
            ::|..|.: |....:..||.|||..||||||.:.:::|.|..|:....|:||||||:.|.|||:|
  Fly   502 SILSRLANTGNPIIEKEIVQWVNNRLSEAGKQSQLRNFNDPAIADGKIVIDLIDAIKEGSINYEL 566

Human   572 VKSGNLTEDDKHNNAKYAVSMARRIGARVYALPEDLVEVKPKMVMTVFACLM 623
            |::.. |::|...|||||:||||:|||||||||||:.|||||||||||||:|
  Fly   567 VRTSG-TQEDNLANAKYAISMARKIGARVYALPEDITEVKPKMVMTVFACMM 617

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PLS3NP_001129497.1 EFh 16..82 CDD:238008 22/70 (31%)
CH_PLS_rpt1 101..245 CDD:409141 84/143 (59%)
Actin-binding 1 109..382 154/273 (56%)
CH_PLS3_rpt2 254..375 CDD:409177 67/121 (55%)
CH_PLS3_rpt3 377..510 CDD:409180 86/139 (62%)
Actin-binding 2 383..627 149/249 (60%)
CH_PLS3_rpt4 519..630 CDD:409183 63/105 (60%)
FimNP_728074.1 EF-hand_7 27..84 CDD:290234 20/61 (33%)
EFh 27..80 CDD:298682 18/57 (32%)
CH 127..237 CDD:278723 64/109 (59%)
CH 271..370 CDD:278723 56/105 (53%)
CH 396..497 CDD:214479 69/103 (67%)
CH 517..619 CDD:214479 63/102 (62%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165152963
Domainoid 1 1.000 144 1.000 Domainoid score I4611
eggNOG 1 0.900 - - E2759_KOG0046
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 613 1.000 Inparanoid score I913
Isobase 1 0.950 - 0 Normalized mean entropy S1063
OMA 1 1.010 - - QHG54335
OrthoDB 1 1.010 - - D138895at33208
OrthoFinder 1 1.000 - - FOG0000930
OrthoInspector 1 1.000 - - otm40640
orthoMCL 1 0.900 - - OOG6_101115
Panther 1 1.100 - - O PTHR19961
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2112
SonicParanoid 1 1.000 - - X500
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.750

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