DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ilk and VIK

DIOPT Version :9

Sequence 1:	NP_525001.2	Gene:	Ilk / 53573	FlyBaseID:	FBgn0028427	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_172853.1	Gene:	VIK / 837960	AraportID:	AT1G14000	Length:	438	Species:	Arabidopsis thaliana

Alignment Length:	432	Identity:	111/432 - (25%)
Similarity:	184/432 - (42%)	Gaps:	74/432 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 WVAKEGHAKLVETLLQRG-SRVNATNMGDDIPLHLAAAHGHRDVVQMLIKERSDVNAVNEHGNTP 103
            |.|.:..|..|..||:.. :.|:|.:.....|||:|:.||..|||:.|::..:||||.:...|||
plant    43 WHAHQNDAAAVRKLLEEDPTLVHARDYDKRTPLHVASLHGWIDVVKCLLEFGADVNAQDRWKNTP 107

  Fly   104 LHYACFWG---YDMICEDLLNAGAQVGIANKDGHTPLEKAKPSLAKRLQDLVEKSGREVKVISFK 165
            |  |...|   ..||  :||.:...:.......|...:...|.:.|:.
plant   108 L--ADAEGARKQKMI--ELLKSHGGLSYGQNGSHFEPKPVPPPIPKKC----------------- 151

  Fly   166 EQSWQGLKTRSRDATLSRFKGISMGDLDLHTKLSVTPS--GETWRGRWQKNDVVAKILAVRQCTP 228
              .|:                |...:||......:...  ||..:..|:...|     ||::..|
plant   152 --DWE----------------IEPAELDFSNAAMIGKGSFGEIVKAYWRGTPV-----AVKRILP 193

  Fly   229 RIS------RDFNEEFPKLRIFSHPNILPIIGACNSPPNLVTISQFMPRSSLFSLLHGATGVVVD 287
            .:|      :||..|...|....||||:..:||......|:.|::::....|...|....|:...
plant   194 SLSDDRLVIQDFRHEVDLLVKLRHPNIVQFLGAVTERKPLMLITEYLRGGDLHQYLKEKGGLTPT 258

  Fly   288 TSQAVSFALDVARGMAFLHSLERIIPTYHLNSHHVMIDDDLTARINMGDAKFS----FQEKGRIY 348
            |  ||:||||:||||.:||:...:|....|...:|::.:.....:.:||...|    .|....:|
plant   259 T--AVNFALDIARGMTYLHNEPNVIIHRDLKPRNVLLVNSSADHLKVGDFGLSKLIKVQNSHDVY 321

  Fly   349 QPA-------WMSPETLQRKQADRNWEACDMWSFAILIWELTTREVPFAEWSPMECGMKIALEGL 406
            :..       :|:||..:.::.|:.   .|::|||::::|:...|.|||...|.|....:: :|.
plant   322 KMTGETGSYRYMAPEVFKHRRYDKK---VDVFSFAMILYEMLEGEPPFANHEPYEAAKHVS-DGH 382

  Fly   407 RVKI-PPGTSTHMAKLISICMNEDPGKRPKFDMVVPILEKMR 447
            |... ..|.:..:.:||..|.:.|..:||.|..::..|||::
plant   383 RPTFRSKGCTPDLRELIVKCWDADMNQRPSFLDILKRLEKIK 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ilk	NP_525001.2	ANK	28..140	CDD:238125	33/103 (32%)
		ANK repeat	33..64	CDD:293786	8/24 (33%)
		Ank_2	38..130	CDD:289560	32/93 (34%)
		ANK repeat	66..97	CDD:293786	14/30 (47%)
		ANK repeat	99..130	CDD:293786	10/33 (30%)
		PK_ILK	196..446	CDD:270959	71/269 (26%)
		STYKc	204..443	CDD:214568	69/256 (27%)
VIK	NP_172853.1	ANK repeat	36..68	CDD:293786	8/24 (33%)
		PTZ00322	45..>126	CDD:140343	31/84 (37%)
		ANK repeat	70..101	CDD:293786	14/30 (47%)
		ANK repeat	103..127	CDD:293786	10/27 (37%)
		STKc_MAP3K-like	168..420	CDD:270901	69/262 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	126	1.000	Inparanoid score	I1926
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.960