Protein Alignment Ilk and Lrrk

DIOPT Version :10

• Sequence 1: NP_525001.2
• Gene: Ilk / 53573
• FlyBaseID: FBgn0028427
• Length: 448
• Species: Drosophila melanogaster
• Sequence 2: NP_001262772.1
• Gene: Lrrk / 42447
• FlyBaseID: FBgn0038816
• Length: 2513
• Species: Drosophila melanogaster
• Alignment Length: 308
• Identity: 78/308 - (25%)
• Similarity: 125/308 - (40%)
• Gaps: 64/308 - (20%)

  Fly   163 SFKEQSWQGLK-----TRSRDATLSRFKGISMGDLDLHTKLSVTPSGETWRGRWQKNDVVAKILA 222
            |||..:.:.|:     .|::::.|..|            |::|        |:|.::.:.....|
  Fly  1822 SFKPVAMKMLQPVPPGARAKESALMAF------------KVAV--------GKWDRDPLQHSCKA 1866

  Fly   223 VRQCTPRISRDFNEEFPKLRIFSHPNILPIIGACNSPPNLVTISQFMPRSSLFSLL--HGATGVV 285
              .||.|      :|...|....||||:|::|.|..|  |..:.:..|...|.:||  :..:|..
  Fly  1867 --YCTAR------QELAVLLTLKHPNIVPLVGICIKP--LALVLELAPLGGLDALLRHYRRSGAH 1921

  Fly   286 VDTSQAVSFALDVARGMAFLHSLERIIPTYH-LNSHHVMI--------DDD--LTARINMGDAKF 339
            :......:..|..||.:.:||. .|||  |. |.|.:|::        :|.  ....|.:.|...
  Fly  1922 MGPHTFQTLVLQAARAIEYLHR-RRII--YRDLKSENVLVWELPQPHTEDSPRNLVHIKIADYGI 1983

  Fly   340 SFQ-----EKGRIYQPAWMSPETLQRKQADRNWEACDMWSFAILIWELTTREVPF-AEWSPMEC- 397
            |.|     .||......:|:||.::....:...|..|.:||.:.|:|..:...|| ...|..||
  Fly  1984 SRQTAPSGAKGFGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISLRQPFEGHESIKECI 2048

  Fly   398 --GMKIALEGLRVKIPPGTSTHMAKLISICMNEDPGKRPKFDMVVPIL 443
              |.:.||.....:.|    |....|:.:|.:|.|.:||....:|.||
  Fly  2049 LEGSRPALTQRETQFP----TCCLDLMVLCWHEQPRRRPTASQIVSIL 2092

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ilk	NP_525001.2	ANKYR	<1..162	CDD:440430
		ANK repeat	33..64	CDD:293786
		ANK repeat	66..97	CDD:293786
		ANK repeat	99..130	CDD:293786
		PK_ILK	196..446	CDD:270959	71/270 (26%)
Lrrk	NP_001262772.1	ANKYR	78..>287	CDD:440430
		ANK repeat	146..177	CDD:293786
		ANK repeat	179..209	CDD:293786
		ANK repeat	361..390	CDD:293786
		Ank_2	364..465	CDD:463710
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR	<544..>768	CDD:443914
		leucine-rich repeat	547..569	CDD:275380
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:404697
		leucine-rich repeat	855..901	CDD:275380
		LRR_4	900..941	CDD:463713
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop containing Nucleoside Triphosphate Hydrolases	993..1211	CDD:476819
		COR	1230..>1393	CDD:406489
		STKc_LRRK	1801..2095	CDD:270902	78/308 (25%)