Protein Alignment Ilk and Tak1

DIOPT Version :10

• Sequence 1: NP_525001.2
• Gene: Ilk / 53573
• FlyBaseID: FBgn0028427
• Length: 448
• Species: Drosophila melanogaster
• Sequence 2: NP_524080.1
• Gene: Tak1 / 39659
• FlyBaseID: FBgn0026323
• Length: 678
• Species: Drosophila melanogaster
• Alignment Length: 305
• Identity: 72/305 - (23%)
• Similarity: 123/305 - (40%)
• Gaps: 65/305 - (21%)

  Fly   172 LKTRSRDATLSRFKGISMGDLDLHTKLSVTPSGETWRGRWQKNDVVAKILAVRQ-CTPRISRDFN 235
            :.|.|.||..:.:  :...::.|..|:.....|...:..|:.     |::||:: ......:|..
  Fly     1 MATASLDALQAAY--VDFSEITLREKVGHGSYGVVCKAVWRD-----KLVAVKEFFASAEQKDIE 58

  Fly   236 EEFPKLRIFSHPNILPIIGACNSPPNLVTISQFMPRSSLFSLLHGATGVVVDTSQAVSFALDVAR 300
            :|..:|....||||:.:.|..:.......|.:|....||.:.|||........:.|:|:|...|.
  Fly    59 KEVKQLSRVKHPNIIALHGISSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAE 123

  Fly   301 GMAFLHSLERIIPTYH-----LN-------------SHHVMIDDDLTARINMGDAKFSFQEKGRI 347
            |:|:||::.. .|..|     ||             ....:.|.......|.|.|
  Fly   124 GLAYLHAMTP-KPLIHRDVKPLNLLLTNKGRNLKICDFGTVADKSTMMTNNRGSA---------- 177

  Fly   348 YQPAWMSPETLQRKQADRNWEACDMWSFAILIWELTTREVPF--------AEWSPMECGMKIALE 404
               |||:||..   :..:..|.||::|:||::||:.:|:.||        .:|       || .:
  Fly   178 ---AWMAPEVF---EGSKYTEKCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQW-------KI-YK 228

  Fly   405 GLRVKIPPGTST---HMAKLISICMNEDPGKRPKFDMVVPILEKM 446
            |.|   ||..:|   .:..|::.|....|..||....:|.::.::
  Fly   229 GER---PPLLTTCPKRIEDLMTACWKTVPEDRPSMQYIVGVMHEI 270

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ilk	NP_525001.2	ANKYR	<1..162	CDD:440430
		ANK repeat	33..64	CDD:293786
		ANK repeat	66..97	CDD:293786
		ANK repeat	99..130	CDD:293786
		PK_ILK	196..446	CDD:270959	67/279 (24%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	66/279 (24%)