Protein Alignment Ilk and ILK

DIOPT Version :10

• Sequence 1: NP_525001.2
• Gene: Ilk / 53573
• FlyBaseID: FBgn0028427
• Length: 448
• Species: Drosophila melanogaster
• Sequence 2: NP_004508.1
• Gene: ILK / 3611
• HGNCID: 6040
• Length: 452
• Species: Homo sapiens
• Alignment Length: 450
• Identity: 271/450 - (60%)
• Similarity: 340/450 - (75%)
• Gaps: 3/450 - (0%)

  Fly     1 MEDIFHWCREGNSIQVRLWLDETEHDNNLGDDHGFSPLHWVAKEGHAKLVETLLQRGSRVNATNM 65
            |:|||..|||||::.||||||.||:|.|.|||||||||||..:||.:.:||.|:.||:|:|..|.
Human     1 MDDIFTQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNR 65

  Fly    66 GDDIPLHLAAAHGHRDVVQMLIKERSDVNAVNEHGNTPLHYACFWGYDMICEDLLNAGAQVGIAN 130
            |||.||||||:|||||:||.|::.::|:||||||||.|||||||||.|.:.|||:..||.|.|.|
Human    66 GDDTPLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICN 130

  Fly   131 KDGHTPLEKAKPSLAKRLQDLVEKSGREVKVISFKEQSWQG-LKTRSRDATLSRFKGISMGDLDL 194
            |.|..|::|||..|.:.|::..||.|:.:..|.:|:..|:| .:||.|:.||::..||....|:.
Human   131 KYGEMPVDKAKAPLRELLRERAEKMGQNLNRIPYKDTFWKGTTRTRPRNGTLNKHSGIDFKQLNF 195

  Fly   195 HTKLSVTPSGETWRGRWQKNDVVAKILAVRQCTPRISRDFNEEFPKLRIFSHPNILPIIGACNSP 259
            .|||:...|||.|:||||.||:|.|:|.||..:.|.|||||||.|:||||||||:||::|||.||
Human   196 LTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSP 260

  Fly   260 --PNLVTISQFMPRSSLFSLLHGATGVVVDTSQAVSFALDVARGMAFLHSLERIIPTYHLNSHHV 322
              |:...|:.:||..||:::||..|..|||.||||.||||:||||||||:||.:||.:.|||..|
Human   261 PAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSV 325

  Fly   323 MIDDDLTARINMGDAKFSFQEKGRIYQPAWMSPETLQRKQADRNWEACDMWSFAILIWELTTREV 387
            |||:|:||||:|.|.|||||..||:|.|||::||.||:|..|.|..:.||||||:|:|||.||||
Human   326 MIDEDMTARISMADVKFSFQCPGRMYAPAWVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREV 390

  Fly   388 PFAEWSPMECGMKIALEGLRVKIPPGTSTHMAKLISICMNEDPGKRPKFDMVVPILEKMR 447
            |||:.|.||.|||:||||||..||||.|.|:.||:.|||||||.|||||||:|||||||:
Human   391 PFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMKICMNEDPAKRPKFDMIVPILEKMQ 450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ilk	NP_525001.2	ANKYR	<1..162	CDD:440430	95/160 (59%)
		ANK repeat	33..64	CDD:293786	17/30 (57%)
		ANK repeat	66..97	CDD:293786	20/30 (67%)
		ANK repeat	99..130	CDD:293786	20/30 (67%)
		PK_ILK	196..446	CDD:270959	162/251 (65%)
ILK	NP_004508.1	ANK 1. /evidence=ECO:0000269|PubMed:19074270	2..30		18/27 (67%)
		ANKYR	<8..162	CDD:440430	91/153 (59%)
		ANK 2. /evidence=ECO:0000269|PubMed:19074270	31..63		19/31 (61%)
		Interaction with LIMS1. /evidence=ECO:0000269|PubMed:12167643	33..139		65/105 (62%)
		ANK repeat	33..64	CDD:293786	17/30 (57%)
		ANK repeat	66..97	CDD:293786	20/30 (67%)
		ANK repeat	99..130	CDD:293786	20/30 (67%)
		ANK 5. /evidence=ECO:0000269|PubMed:19074270	130..174		16/43 (37%)
		PH-like, mediates interaction with TGFB1I1. /evidence=ECO:0000250|UniProtKB:O55222	180..212		13/31 (42%)
		PK_ILK	197..449	CDD:270959	162/251 (65%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:17420447	363..371		3/7 (43%)