DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ilk and Takl1

DIOPT Version :9

Sequence 1:	NP_525001.2	Gene:	Ilk / 53573	FlyBaseID:	FBgn0028427	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_732554.1	Gene:	Takl1 / 318725	FlyBaseID:	FBgn0046689	Length:	393	Species:	Drosophila melanogaster

Alignment Length:	280	Identity:	70/280 - (25%)
Similarity:	125/280 - (44%)	Gaps:	37/280 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 KGISMGDLDLHTK-LSVTPSGETWRGRWQKNDVVAKILAVRQCTPRISRDFNEEFPKLRIFSHPN 248
            |.:...::.|..| |.....|...:..:|..::..||....:.|  |.::...|...|....|.|
  Fly     3 KQVDFAEVKLSEKFLGAGSGGAVRKATFQNQEIAVKIFDFLEET--IKKNAEREITHLSEIDHEN 65

  Fly   249 ILPIIGACNSPPNLVTISQFMPRSSLFSLLHGATGVVVDTSQAVSFALDVARGMAFLHSLERIIP 313
            ::.:||..::......:.:::...||.:.|:|.........|||.:||..|:.:|:||||:|  |
  Fly    66 VIRVIGRASNGKKDYLLMEYLEEGSLHNYLYGDDKWEYTVEQAVRWALQCAKALAYLHSLDR--P 128

  Fly   314 TYH----------LNSHHVMIDDDLTARINMGDAKFSFQEKGRIYQPAWMSPETLQRKQADRNWE 368
            ..|          .|.|..:...|.....:|.:.|...|...|     :|:||.::..:....
  Fly   129 IVHRDIKPQNMLLYNQHEDLKICDFGLATDMSNNKTDMQGTLR-----YMAPEAIKHLKYTAK-- 186

  Fly   369 ACDMWSFAILIWELTTREVPF-------AEWSPMEC---GMKIALEGLRVKIPPGTSTHMAKLIS 423
             ||::||.|::|||.||::|:       ::::.|:.   |.|:.:|.:|...|.|    :.:|:.
  Fly   187 -CDVYSFGIMLWELMTRQLPYSHLENPNSQYAIMKAISSGEKLPMEAVRSDCPEG----IKQLME 246

  Fly   424 ICMNEDPGKRPKFDMVVPIL 443
            .||:.:|.|||....:...|
  Fly   247 CCMDINPEKRPSMKEIEKFL 266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ilk	NP_525001.2	ANK	28..140	CDD:238125
		ANK repeat	33..64	CDD:293786
		Ank_2	38..130	CDD:289560
		ANK repeat	66..97	CDD:293786
		ANK repeat	99..130	CDD:293786
		PK_ILK	196..446	CDD:270959	68/269 (25%)
		STYKc	204..443	CDD:214568	65/258 (25%)
Takl1	NP_732554.1	S_TKc	15..262	CDD:214567	67/262 (26%)
Takl1	NP_732554.1	STKc_TAK1	17..274	CDD:270960	67/266 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445256
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840