DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ilk and ZK622.1

DIOPT Version :9

Sequence 1:	NP_525001.2	Gene:	Ilk / 53573	FlyBaseID:	FBgn0028427	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_494994.1	Gene:	ZK622.1 / 191366	WormBaseID:	WBGene00022780	Length:	419	Species:	Caenorhabditis elegans

Alignment Length:	243	Identity:	52/243 - (21%)
Similarity:	99/243 - (40%)	Gaps:	43/243 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 TPRISRDFNEEFPKLRIFSHPNILPIIGACNSPPNLVTISQFMPRSSLFSLLHGATGVVVDTSQA 291
            |..:..|..:|...:|.:.|||::...|.|.....::.:.:...:.:|.|.|..... .|.....
Worm   179 TRAMIEDVCKEARIMRQYQHPNVVCFFGVCVEKEPIMLVMELASQGALDSFLKNEKN-NVSLRDK 242

  Fly   292 VSFALDVARGMAFLHS---LERIIPTYHLNSHH--VMIDD--------DLTARINMGD--AKFSF 341
            :.::.|.::|:.:||.   :.|.:...:...|.  |.|.|        ||..:..:.|  ||...
Worm   243 LKYSFDASKGLEYLHQHGCIHRDVAARNFLMHKNVVKITDFGLSKQLSDLAHKYKLKDIQAKLPI 307

  Fly   342 QEKGRIYQPAWMSPETLQRKQADRNWEACDMWSFAILIWEL-TTREVPFAEWSPMECGMKIA--- 402
            :         |::||.:  ..|...::: |::||.||:||: ....:|:.       |||:|
Worm   308 R---------WLAPEVI--VTATYTFKS-DVYSFGILLWEIFMDGAIPYP-------GMKLAEVK 353

  Fly   403 ---LEGLRVKIPPGTSTHMAK-LISICMNEDPGKRPKFDMVVPILEKM 446
               ..|.|:..|......:.. :||.|..::|..|...:.:...:|.:
Worm   354 QKVKNGYRMDAPDRMPAFVRNIMISQCWPQNPEDRGNMNEIRLAMESV 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ilk	NP_525001.2	ANK	28..140	CDD:238125
		ANK repeat	33..64	CDD:293786
		Ank_2	38..130	CDD:289560
		ANK repeat	66..97	CDD:293786
		ANK repeat	99..130	CDD:293786
		PK_ILK	196..446	CDD:270959	52/241 (22%)
		STYKc	204..443	CDD:214568	51/238 (21%)
ZK622.1	NP_494994.1	SH2_Fps_family	25..114	CDD:198224
		TyrKc	138..398	CDD:197581	51/238 (21%)
		PTKc	142..399	CDD:270623	51/239 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000