DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ilk and pat-4

DIOPT Version :9

Sequence 1:	NP_525001.2	Gene:	Ilk / 53573	FlyBaseID:	FBgn0028427	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_497139.1	Gene:	pat-4 / 175175	WormBaseID:	WBGene00003931	Length:	466	Species:	Caenorhabditis elegans

Alignment Length:	447	Identity:	262/447 - (58%)
Similarity:	342/447 - (76%)	Gaps:	1/447 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDIFHWCREGNSIQVRLWLDETEHDNNLGDDHGFSPLHWVAKEGHAKLVETLLQRGSRVNATNM 65
            |||:|.|.||||:.|||:|||:.|||.|:||||.||.|||.||.||..:.|.||.||:|||:|||
Worm    18 MEDVFGWVREGNAFQVRVWLDDHEHDLNVGDDHAFSLLHWAAKGGHVAIAEMLLSRGARVNSTNM 82

  Fly    66 GDDIPLHLAAAHGHRDVVQMLIKERSDVNAVNEHGNTPLHYACFWGYDMICEDLLNAGAQVGIAN 130
            |||..||||||||||.:|..|:..::||||.||||.|||||||||||:.|.|||::.||.|.:.|
Worm    83 GDDTSLHLAAAHGHRQIVVKLLSRKADVNATNEHGMTPLHYACFWGYEQIAEDLISCGAAVNVCN 147

  Fly   131 KDGHTPLEKAKPSLAKRLQDLVEKSGREVK-VISFKEQSWQGLKTRSRDATLSRFKGISMGDLDL 194
            |.|.|||:..:|.....:.::.::.|:... .:.||:.:|:|.|:|:|||||||:.|:.:..|:|
Worm   148 KKGMTPLDVCQPMCKNTILEIAQEHGQSPNDRVPFKDTTWKGTKSRTRDATLSRYTGVDVSSLNL 212

  Fly   195 HTKLSVTPSGETWRGRWQKNDVVAKILAVRQCTPRISRDFNEEFPKLRIFSHPNILPIIGACNSP 259
            .||::.:.|||.|||:||.||:||:||.|::.|.||||||..|||.||||:||||..::.|.|.|
Worm   213 ITKIAESHSGELWRGKWQGNDIVARILNVQEVTARISRDFQTEFPALRIFAHPNICAVLAAANQP 277

  Fly   260 PNLVTISQFMPRSSLFSLLHGATGVVVDTSQAVSFALDVARGMAFLHSLERIIPTYHLNSHHVMI 324
            ||||.|||:||..||:::||..:.||:|..|||.||||:||||::||||:.::..::|:|.||::
Worm   278 PNLVIISQYMPFGSLYNVLHEQSSVVIDHGQAVRFALDIARGMSYLHSLDPMLLRFYLSSKHVVV 342

  Fly   325 DDDLTARINMGDAKFSFQEKGRIYQPAWMSPETLQRKQADRNWEACDMWSFAILIWELTTREVPF 389
            |::|||:::|.|.||||||.|:.|.|||||||.|.|...|.|..|.||||||||:|||.||||||
Worm   343 DEELTAKLSMADTKFSFQEVGKAYSPAWMSPEALSRAPEDLNIRAADMWSFAILLWELNTREVPF 407

  Fly   390 AEWSPMECGMKIALEGLRVKIPPGTSTHMAKLISICMNEDPGKRPKFDMVVPILEKM 446
            ::..|||||||||||||||.||||.:.:|.:|::||||||||:||.||.::||||:|
Worm   408 SDLPPMECGMKIALEGLRVHIPPGIARNMNRLMNICMNEDPGRRPNFDQIIPILERM 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ilk	NP_525001.2	ANK	28..140	CDD:238125	72/111 (65%)
		ANK repeat	33..64	CDD:293786	18/30 (60%)
		Ank_2	38..130	CDD:289560	59/91 (65%)
		ANK repeat	66..97	CDD:293786	19/30 (63%)
		ANK repeat	99..130	CDD:293786	20/30 (67%)
		PK_ILK	196..446	CDD:270959	153/249 (61%)
		STYKc	204..443	CDD:214568	147/238 (62%)
pat-4	NP_497139.1	ANK	45..157	CDD:238125	72/111 (65%)
		ANK repeat	52..81	CDD:293786	17/28 (61%)
		Ank_2	55..147	CDD:289560	59/91 (65%)
		ANK repeat	83..114	CDD:293786	19/30 (63%)
		ANK repeat	116..147	CDD:293786	20/30 (67%)
		Pkinase_Tyr	210..461	CDD:285015	152/250 (61%)
		PK_ILK	214..464	CDD:270959	153/249 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156085
Domainoid	1	1.000	329	1.000	Domainoid score	I622
eggNOG	1	0.900	-	-		E2759_KOG0195
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3318
Inparanoid	1	1.050	574	1.000	Inparanoid score	I565
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58783
OrthoDB	1	1.010	-	-		D324283at33208
OrthoFinder	1	1.000	-	-		FOG0007245
OrthoInspector	1	1.000	-	-		oto19732
orthoMCL	1	0.900	-	-		OOG6_107009
Panther	1	1.100	-	-	LDO	PTHR44329
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4351
SonicParanoid	1	1.000	-	-		X5350
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800