DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ilk and Ilk

DIOPT Version :9

Sequence 1:NP_525001.2 Gene:Ilk / 53573 FlyBaseID:FBgn0028427 Length:448 Species:Drosophila melanogaster
Sequence 2:NP_001155196.1 Gene:Ilk / 16202 MGIID:1195267 Length:452 Species:Mus musculus


Alignment Length:450 Identity:269/450 - (59%)
Similarity:339/450 - (75%) Gaps:3/450 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MEDIFHWCREGNSIQVRLWLDETEHDNNLGDDHGFSPLHWVAKEGHAKLVETLLQRGSRVNATNM 65
            |:|||..|||||::.||||||.||:|.|.|||||||||||..:||.:.:||.|:.||:|:|..|.
Mouse     1 MDDIFTQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNR 65

  Fly    66 GDDIPLHLAAAHGHRDVVQMLIKERSDVNAVNEHGNTPLHYACFWGYDMICEDLLNAGAQVGIAN 130
            |||.||||||:|||||:||.|::.::|:||||||||.|||||||||.|.:.|||:..||.|.|.|
Mouse    66 GDDTPLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICN 130

  Fly   131 KDGHTPLEKAKPSLAKRLQDLVEKSGREVKVISFKEQSWQG-LKTRSRDATLSRFKGISMGDLDL 194
            |.|..|::|||..|.:.|::..||.|:.:..|.:|:..|:| .:||.|:.||::..||....|:.
Mouse   131 KYGEMPVDKAKAPLRELLRERAEKMGQNLNRIPYKDTFWKGTTRTRPRNGTLNKHSGIDFKQLNF 195

  Fly   195 HTKLSVTPSGETWRGRWQKNDVVAKILAVRQCTPRISRDFNEEFPKLRIFSHPNILPIIGACNSP 259
            ..||:...|||.|:||||.||:|.|:|.||..:.|.|||||||.|:||||||||:||::|||.:|
Mouse   196 LAKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQAP 260

  Fly   260 --PNLVTISQFMPRSSLFSLLHGATGVVVDTSQAVSFALDVARGMAFLHSLERIIPTYHLNSHHV 322
              |:...|:.:||..||:::||..|..|||.||||.||||:||||||||:||.:||.:.|||..|
Mouse   261 PAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSV 325

  Fly   323 MIDDDLTARINMGDAKFSFQEKGRIYQPAWMSPETLQRKQADRNWEACDMWSFAILIWELTTREV 387
            |||:|:||||:|.|.|||||..||:|.|||::||.||:|..|.|..:.||||||:|:|||.||||
Mouse   326 MIDEDMTARISMADVKFSFQCPGRMYAPAWVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREV 390

  Fly   388 PFAEWSPMECGMKIALEGLRVKIPPGTSTHMAKLISICMNEDPGKRPKFDMVVPILEKMR 447
            |||:.|.||.|||:||||||..||||.|.|:.||:.|||||||.|||||||:|||||||:
Mouse   391 PFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMKICMNEDPAKRPKFDMIVPILEKMQ 450

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IlkNP_525001.2 ANK 28..140 CDD:238125 69/111 (62%)
ANK repeat 33..64 CDD:293786 17/30 (57%)
Ank_2 38..130 CDD:289560 56/91 (62%)
ANK repeat 66..97 CDD:293786 20/30 (67%)
ANK repeat 99..130 CDD:293786 20/30 (67%)
PK_ILK 196..446 CDD:270959 160/251 (64%)
STYKc 204..443 CDD:214568 154/240 (64%)
IlkNP_001155196.1 ANK 1 2..30 18/27 (67%)
Ank_4 4..54 CDD:372654 32/49 (65%)
ANK 2 31..63 19/31 (61%)
Interaction with LIMS1. /evidence=ECO:0000250 33..139 65/105 (62%)
ANK repeat 33..64 CDD:293786 17/30 (57%)
Ank_2 38..124 CDD:403870 52/85 (61%)
ANK repeat 66..97 CDD:293786 20/30 (67%)
ANK repeat 99..130 CDD:293786 20/30 (67%)
ANK 5 130..174 16/44 (36%)
PH-like, mediates interaction with TGFB1I1. /evidence=ECO:0000269|PubMed:16737959 180..212 13/31 (42%)
PK_ILK 198..449 CDD:270959 161/251 (64%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167830694
Domainoid 1 1.000 331 1.000 Domainoid score I1150
eggNOG 1 0.900 - - E2759_KOG0195
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H3318
Inparanoid 1 1.050 569 1.000 Inparanoid score I1060
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG58783
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0007245
OrthoInspector 1 1.000 - - oto93115
orthoMCL 1 0.900 - - OOG6_107009
Panther 1 1.100 - - LDO PTHR44329
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4351
SonicParanoid 1 1.000 - - X5350
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1514.790

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