DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ilk and ilk

DIOPT Version :9

Sequence 1:	NP_525001.2	Gene:	Ilk / 53573	FlyBaseID:	FBgn0028427	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_001120512.1	Gene:	ilk / 100145644	XenbaseID:	XB-GENE-1014172	Length:	452	Species:	Xenopus tropicalis

Alignment Length:	450	Identity:	266/450 - (59%)
Similarity:	339/450 - (75%)	Gaps:	3/450 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDIFHWCREGNSIQVRLWLDETEHDNNLGDDHGFSPLHWVAKEGHAKLVETLLQRGSRVNATNM 65
            |:|||..|||||::.||||||.||:|.|.|||||||||||..:||.:.:|:.|:.||:|:|..|.
Frog     1 MDDIFAQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSNIVDMLIMRGARINVMNR 65

  Fly    66 GDDIPLHLAAAHGHRDVVQMLIKERSDVNAVNEHGNTPLHYACFWGYDMICEDLLNAGAQVGIAN 130
            |||.||||||:|||||:||.||:.::||||||||||.||||||||..:.:.|||:|....:.|.|
Frog    66 GDDTPLHLAASHGHRDIVQKLIQYKADVNAVNEHGNAPLHYACFWAQEEVAEDLVNNSGLIYICN 130

  Fly   131 KDGHTPLEKAKPSLAKRLQDLVEKSGREVKVISFKEQSWQG-LKTRSRDATLSRFKGISMGDLDL 194
            |.|.|||:|||..|.:.|:|..||.|:.:..|.:|:..|:| .:||.|:.||::..||....|.|
Frog   131 KYGETPLDKAKAQLKELLKDRAEKMGQSMSRIPYKDTFWKGTTRTRPRNGTLNKQAGIDYKQLTL 195

  Fly   195 HTKLSVTPSGETWRGRWQKNDVVAKILAVRQCTPRISRDFNEEFPKLRIFSHPNILPIIGACNSP 259
            ..||:...|||.|:||||.||::.|:|.:|..:.|.|||||||:||||||||||:||::|||.||
Frog   196 SHKLNDNHSGELWKGRWQGNDIIIKVLKIRDWSTRKSRDFNEEYPKLRIFSHPNVLPVLGACQSP 260

  Fly   260 --PNLVTISQFMPRSSLFSLLHGATGVVVDTSQAVSFALDVARGMAFLHSLERIIPTYHLNSHHV 322
              |:.|.|:.:||..||:::||..|.:|||..|||.|.||:||||||||:||.:||.::|||..:
Frog   261 PAPHPVLITHWMPYGSLYNVLHEGTNLVVDQCQAVKFGLDIARGMAFLHTLEPLIPRHYLNSRSI 325

  Fly   323 MIDDDLTARINMGDAKFSFQEKGRIYQPAWMSPETLQRKQADRNWEACDMWSFAILIWELTTREV 387
            |||:|:||||:|.|.|.|||..||||.|||::||.||::..|.|..:.||||||:|:|||.||||
Frog   326 MIDEDMTARISMADVKLSFQCPGRIYSPAWVAPEALQKRPEDINRRSADMWSFAVLLWELVTREV 390

  Fly   388 PFAEWSPMECGMKIALEGLRVKIPPGTSTHMAKLISICMNEDPGKRPKFDMVVPILEKMR 447
            |||:.|.||.|||::|||||..||||.|.|:.||:.|||||||.|||||||:|||||||:
Frog   391 PFADLSNMEIGMKVSLEGLRPTIPPGISPHICKLMKICMNEDPAKRPKFDMIVPILEKMQ 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ilk	NP_525001.2	ANK	28..140	CDD:238125	68/111 (61%)
		ANK repeat	33..64	CDD:293786	16/30 (53%)
		Ank_2	38..130	CDD:289560	53/91 (58%)
		ANK repeat	66..97	CDD:293786	22/30 (73%)
		ANK repeat	99..130	CDD:293786	16/30 (53%)
		PK_ILK	196..446	CDD:270959	156/251 (62%)
		STYKc	204..443	CDD:214568	150/240 (63%)
ilk	NP_001120512.1	Ank_2	8..97	CDD:289560	57/88 (65%)
		ANK	28..140	CDD:238125	68/111 (61%)
		ANK repeat	33..64	CDD:293786	16/30 (53%)
		ANK repeat	66..97	CDD:293786	22/30 (73%)
		Ank_5	86..140	CDD:290568	31/53 (58%)
		ANK repeat	99..130	CDD:293786	16/30 (53%)
		Pkinase_Tyr	193..446	CDD:285015	155/252 (62%)
		PK_ILK	197..449	CDD:270959	156/251 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	260	1.000	Domainoid score	I1944
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3318
Inparanoid	1	1.050	495	1.000	Inparanoid score	I1362
OMA	1	1.010	-	-		QHG58783
OrthoDB	1	1.010	-	-		D324283at33208
OrthoFinder	1	1.000	-	-		FOG0007245
OrthoInspector	1	1.000	-	-		oto103371
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4351
SonicParanoid	1	1.000	-	-		X5350
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.010