DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pins and Gpsm1

DIOPT Version :9

Sequence 1:	NP_524999.2	Gene:	pins / 53569	FlyBaseID:	FBgn0040080	Length:	658	Species:	Drosophila melanogaster
Sequence 2:	NP_001186076.1	Gene:	Gpsm1 / 67839	MGIID:	1915089	Length:	705	Species:	Mus musculus

Alignment Length:	675	Identity:	317/675 - (46%)
Similarity:	418/675 - (61%)	Gaps:	135/675 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 CLELALEGERLCKAGDCRAGVAFFQAAIQAGTEDLRTLSAIYSQLGNAYFYLGDYNKAMQYHKHD 107
            ||||||||||||||||.:||||||:||:|.|||||:||||||||||||||||.:|.:|:|:||||
Mouse    60 CLELALEGERLCKAGDFKAGVAFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLKEYARALQFHKHD 124

  Fly   108 LTLAKSMNDRLGEAKSSGNLGNTLKVMGRFDEAAICCERHLTLARQLGDRLSEGRALYNLGNVYH 172
            |.||:::.||:||||:||||||||||:||||||.:||:|||.:|::.||::.|.|||||:|||||
Mouse   125 LLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAIVCCQRHLDIAQEQGDKVGEARALYNIGNVYH 189

  Fly   173 AKGKHL---GQRNPGKFGDDVKEALTRAVEFYQENLKLMRDLGDRGAQGRACGNLGNTYYLLGDF 234
            ||||.|   ..::||....||:|.|.||.|||:.||.|:::||||.|||||.||||||:||||:|
Mouse   190 AKGKQLSWNAAQDPGHLPPDVRETLHRASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNF 254

  Fly   235 QAAIEHHQERLRIAREFGDRAAERRANSNLGNSHIFLGQFEDAAEHYKRTLALAVELGEREVEAQ 299
            ..|...|:|||.||:||||:||||||.|||||:|||||:|:.||||||:||.|:.:|.::.||||
Mouse   255 TEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQLRDQAVEAQ 319

  Fly   300 SCYSLGNTYTLLHEFNTAIEYHNRHLAIAQELGDRIGEARACWSLGNAHSAIGGHERALKYAEQH 364
            :|||||||||||.::..|.|||.|||.|||||.||:||.|||||||||:.::|...:||.:|::|
Mouse   320 ACYSLGNTYTLLQDYERAAEYHLRHLVIAQELADRVGEGRACWSLGNAYVSMGSPAQALTFAKKH 384

  Fly   365 LQLAKELHDPVGESTARVNISDLRKLLGMPDSEPSPTEEEARSTASDHSASGNQSDGSENSQGRM 429
            ||:::|:.|..||.|||:||:.|:..||...| |:..|:.        ..:|.::.|:     |.
Mouse   385 LQISQEIGDRNGELTARMNIAHLQLALGRLTS-PAAAEKP--------DLAGYEAQGA-----RP 435

  Fly   430 VRVRRQSMEQLDLIKITPD--------------------------GKRMQE-------------- 454
            .|.:|.|.|..||:::..|                          .::.||
Mouse   436 KRTQRLSAETWDLLRLPLDREQNGETHHTGDWRGPGRDSLPLPMRSRKYQEGPDAIERRPREGSH 500

  Fly   455 -----EKLRAQATR----KAKDDD---FFEMLSRSQSKRMDDQRCSIKVNPAGAPAVATGATRKP 507
                 ..:|.|..|    :|...|   ||::||:.||.|||||||.::...||| |.||.|   |
Mouse   501 SPLDSADVRVQVPRTGIPRAPSSDEECFFDLLSKFQSSRMDDQRCPLEEGQAGA-AEATAA---P 561

  Fly   508 LVQ----QNSLFVDPT------------------------NLPGLKSPSSANPSAIGHGPLARSA 544
            .|:    |:|:...|.                        :||||:    ...:.:||   .|..
Mouse   562 SVEDRAAQSSVTASPQTEEFFDLIASSQSRRLDDQRASVGSLPGLR----ITLNNVGH---LRGD 619

  Fly   545 TTTQQPDDDFLDMLMRCQGSRLEEQRSELPRPNVTMDAEAEAPPRSVPEAAVPGAPRGQTGRGAT 609
            ...|:|.|:|.:||::.|.||:::||.              .||..:|             ||.|
Mouse   620 GDAQEPGDEFFNMLIKYQSSRIDDQRC--------------PPPDVLP-------------RGPT 657

  Fly   610 VPDEDFFSLIMKVQSGRMEDQRASI 634
            :|||||||||.:||:.||::||..:
Mouse   658 MPDEDFFSLIQRVQAKRMDEQRVDL 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pins	NP_524999.2	TPR_12	78..153	CDD:290160	54/74 (73%)
		TPR	83..114	CDD:197478	22/30 (73%)
		TPR repeat	83..109	CDD:276809	19/25 (76%)
		TPR repeat	120..150	CDD:276809	24/29 (83%)
		TPR_12	121..203	CDD:290160	53/84 (63%)
		TPR_12	162..250	CDD:290160	56/90 (62%)
		TPR repeat	162..199	CDD:276809	23/39 (59%)
		TPR	219..251	CDD:197478	20/31 (65%)
		TPR repeat	219..246	CDD:276809	17/26 (65%)
		TPR repeat	251..291	CDD:276809	29/39 (74%)
		TPR_12	259..330	CDD:290160	47/70 (67%)
		TPR repeat	296..326	CDD:276809	21/29 (72%)
		TPR_12	298..370	CDD:290160	45/71 (63%)
		TPR	298..330	CDD:197478	22/31 (71%)
		TPR repeat	338..366	CDD:276809	14/27 (52%)
		GoLoco	468..488	CDD:280368	13/22 (59%)
		GoLoco	552..573	CDD:280368	9/20 (45%)
		GoLoco	613..633	CDD:280368	13/19 (68%)
Gpsm1	NP_001186076.1	TPR repeat	63..88	CDD:276809	21/24 (88%)
		TPR_12	99..170	CDD:290160	51/70 (73%)
		TPR repeat	100..126	CDD:276809	19/25 (76%)
		TPR repeat	137..167	CDD:276809	24/29 (83%)
		TPR_1	138..170	CDD:278916	24/31 (77%)
		TPR_12	178..270	CDD:290160	56/91 (62%)
		TPR_12	239..310	CDD:290160	50/70 (71%)
		TPR repeat	239..266	CDD:276809	17/26 (65%)
		TPR repeat	271..307	CDD:276809	28/35 (80%)
		TPR_12	279..350	CDD:290160	47/70 (67%)
		TPR_1	279..307	CDD:278916	21/27 (78%)
		TPR_12	318..390	CDD:290160	45/71 (63%)
		TPR repeat	318..345	CDD:276809	18/26 (69%)
		TPR_7	320..354	CDD:289919	23/33 (70%)
		TPR repeat	352..386	CDD:276809	18/33 (55%)
		GoLoco	526..547	CDD:280368	13/20 (65%)
		GoLoco	579..599	CDD:280368	0/19 (0%)
		GoLoco	626..648	CDD:214645	9/35 (26%)
		GoLoco	661..682	CDD:280368	13/20 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838034
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1130
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	583	1.000	Inparanoid score	I1003
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45855
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003000
OrthoInspector	1	1.000	-	-		otm44259
orthoMCL	1	0.900	-	-		OOG6_104563
Panther	1	1.100	-	-	LDO	PTHR45954
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4056
SonicParanoid	1	1.000	-	-		X1993
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.790