DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pins and gpsm1b

DIOPT Version :9

Sequence 1:	NP_524999.2	Gene:	pins / 53569	FlyBaseID:	FBgn0040080	Length:	658	Species:	Drosophila melanogaster
Sequence 2:	NP_001007779.1	Gene:	gpsm1b / 493623	ZFINID:	ZDB-GENE-110203-5	Length:	634	Species:	Danio rerio

Alignment Length:	638	Identity:	303/638 - (47%)
Similarity:	407/638 - (63%)	Gaps:	92/638 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 CLELALEGERLCKAGDCRAGVAFFQAAIQAGTEDLRTLSAIYSQLGNAYFYLGDYNKAMQYHKHD 107
            ||||||||||||||||.:.|.|||:||:|.|||||:||||||||||||||||.:|.|||:||:||
Zfish    25 CLELALEGERLCKAGDFKGGTAFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLKEYGKAMEYHRHD 89

  Fly   108 LTLAKSMNDRLGEAKSSGNLGNTLKVMGRFDEAAICCERHLTLARQLGDRLSEGRALYNLGNVYH 172
            ||||:::.||:||.|:||||||||||:|::||||:||:|||.::::.||::.|.|||||:|||:|
Zfish    90 LTLARTIGDRVGEGKASGNLGNTLKVLGQYDEAAVCCQRHLDISQEQGDKVGEARALYNIGNVFH 154

  Fly   173 AKGKHLGQ-----RNPGKFGDDVKEALTRAVEFYQENLKLMRDLGDRGAQGRACGNLGNTYYLLG 232
            ||||.  |     :..|....||:|.|.||..||:.||.|::|||||.|||||.||||||:||||
Zfish   155 AKGKQ--QLWGVCQERGDLPPDVRETLQRATAFYEMNLSLVKDLGDRAAQGRAFGNLGNTHYLLG 217

  Fly   233 DFQAAIEHHQERLRIAREFGDRAAERRANSNLGNSHIFLGQFEDAAEHYKRTLALAVELGEREVE 297
            :|..||:.|:|||.||:||||:||||||.|||||:.||||||..|.|:|::||.|:.:|.::.:|
Zfish   218 NFVEAIKFHRERLAIAKEFGDKAAERRAYSNLGNALIFLGQFSAATEYYRKTLQLSRQLKDQVME 282

  Fly   298 AQSCYSLGNTYTLLHEFNTAIEYHNRHLAIAQELGDRIGEARACWSLGNAHSAIGGHERALKYAE 362
            ||:|||||||:|||.|:..||:||.:||.|||||.||:||.||||||||.:.::|...:||.|:.
Zfish   283 AQACYSLGNTHTLLQEYERAIDYHLKHLLIAQELNDRVGEGRACWSLGNVYVSLGNLRQALHYSR 347

  Fly   363 QHLQLAKELHDPVGESTARVNISDLRKLLGMPDSEPSPTE-----EEARSTASDHS--------- 413
            :||.:::|:.|..||.|||:|:.:|.:.||:.:.|.||||     :.||...|..|
Zfish   348 RHLDISREISDCNGELTARLNVEELMEALGVKEDELSPTEPHFKLQGARPKLSKKSSMDSVELWK 412

  Fly   414 -ASGNQSDGSENSQGRMVRVRRQSMEQLDL-IKITPDGKRMQEEKLRAQATRKAKDDD-FFEMLS 475
             ::....|.::....|..|..:.:::..|: :.:||           .:..|...|:| ||::||
Zfish   413 FSAEKNGDAADVCVSRSSRSLQSAVDTEDITVSVTP-----------TKLPRDPSDEDCFFDLLS 466

  Fly   476 RSQSKRMDDQRCSIKVNPAGAPAVATGATRKPLV--------QQNSLF---------------VD 517
            :.||.|||||||.:...|.|..|.|...|...::        |...||               |:
Zfish   467 KFQSSRMDDQRCQLDETPDGEEAGADQNTLNDMIDASLLTSPQTEELFDLIASTQSRRLDDQRVN 531

  Fly   518 PTNLPGLKSPSSANPSAIGHGPLARSATTTQQPDDDFLDMLMRCQGSRLEEQRSELPRPNVTMDA 582
            .:|||||:...:......|.|       ..|:|.|||.:||::||.||:::||.
Zfish   532 VSNLPGLRITHNNLGHLCGDG-------DPQEPSDDFFNMLIKCQSSRIDDQRC----------- 578

  Fly   583 EAEAPPRSVPEAAVPGAPRGQTGRGATVPDEDFFSLIMKVQSGRMEDQRASIP 635
               :||.        |.|||..|     .||||||||.:||:.||::||..:|
Zfish   579 ---SPPE--------GGPRGPDG-----SDEDFFSLIQRVQAKRMDEQRVRLP 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pins	NP_524999.2	TPR_12	78..153	CDD:290160	53/74 (72%)
		TPR	83..114	CDD:197478	24/30 (80%)
		TPR repeat	83..109	CDD:276809	20/25 (80%)
		TPR repeat	120..150	CDD:276809	22/29 (76%)
		TPR_12	121..203	CDD:290160	47/86 (55%)
		TPR_12	162..250	CDD:290160	55/92 (60%)
		TPR repeat	162..199	CDD:276809	21/41 (51%)
		TPR	219..251	CDD:197478	21/31 (68%)
		TPR repeat	219..246	CDD:276809	18/26 (69%)
		TPR repeat	251..291	CDD:276809	26/39 (67%)
		TPR_12	259..330	CDD:290160	42/70 (60%)
		TPR repeat	296..326	CDD:276809	19/29 (66%)
		TPR_12	298..370	CDD:290160	42/71 (59%)
		TPR	298..330	CDD:197478	21/31 (68%)
		TPR repeat	338..366	CDD:276809	13/27 (48%)
		GoLoco	468..488	CDD:280368	13/20 (65%)
		GoLoco	552..573	CDD:280368	11/20 (55%)
		GoLoco	613..633	CDD:280368	13/19 (68%)
gpsm1b	NP_001007779.1	TPR repeat	28..53	CDD:276809	19/24 (79%)
		TPR_12	64..135	CDD:290160	50/70 (71%)
		TPR	65..95	CDD:197478	24/29 (83%)
		TPR repeat	65..91	CDD:276809	20/25 (80%)
		TPR repeat	102..132	CDD:276809	22/29 (76%)
		TPR_1	104..132	CDD:278916	21/27 (78%)
		TPR_12	143..235	CDD:290160	55/93 (59%)
		TPR_12	204..275	CDD:290160	48/70 (69%)
		TPR repeat	204..231	CDD:276809	18/26 (69%)
		TPR_7	205..240	CDD:289919	24/34 (71%)
		TPR repeat	236..272	CDD:276809	25/35 (71%)
		TPR_12	244..315	CDD:290160	42/70 (60%)
		TPR_1	244..272	CDD:278916	18/27 (67%)
		TPR_12	283..355	CDD:290160	42/71 (59%)
		TPR repeat	283..310	CDD:276809	17/26 (65%)
		Cas1_I-II-III	<287..>405	CDD:294435	59/117 (50%)
		TPR repeat	323..351	CDD:276809	13/27 (48%)
		GoLoco	459..480	CDD:280368	14/20 (70%)
		GoLoco	510..530	CDD:214645	2/19 (11%)
		GoLoco	559..580	CDD:280368	11/34 (32%)
		GoLoco	593..614	CDD:280368	13/20 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I12155
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	557	1.000	Inparanoid score	I1073
OMA	1	1.010	-	-		QHG45855
OrthoDB	1	1.010	-	-		D321819at33208
OrthoFinder	1	1.000	-	-		FOG0003000
OrthoInspector	1	1.000	-	-		otm25004
orthoMCL	1	0.900	-	-		OOG6_104563
Panther	1	1.100	-	-	LDO	PTHR45954
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4056
SonicParanoid	1	1.000	-	-		X1993
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	12.010