DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pins and gpsm2

DIOPT Version :9

Sequence 1:	NP_524999.2	Gene:	pins / 53569	FlyBaseID:	FBgn0040080	Length:	658	Species:	Drosophila melanogaster
Sequence 2:	XP_005171423.1	Gene:	gpsm2 / 393410	ZFINID:	ZDB-GENE-040426-1169	Length:	670	Species:	Danio rerio

Alignment Length:	690	Identity:	322/690 - (46%)
Similarity:	422/690 - (61%)	Gaps:	145/690 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 CLELALEGERLCKAGDCRAGVAFFQAAIQAGTEDLRTLSAIYSQLGNAYFYLGDYNKAMQYHKHD 107
            ||:||||.|||||.||..|||::|:||||.|||||:.|||:|||||||||:|.||:||:::|.||
Zfish    26 CLDLALEAERLCKVGDYSAGVSYFEAAIQVGTEDLQVLSAVYSQLGNAYFHLHDYSKALEFHHHD 90

  Fly   108 LTLAKSMNDRLGEAKSSGNLGNTLKVMGRFDEAAICCERHLTLARQLGDRLSEGRALYNLGNVYH 172
            |||.::..|||||||:||||||||||:||||||.:||:|||.:||:|||::.:.|||||.|||||
Zfish    91 LTLTRTTGDRLGEAKASGNLGNTLKVLGRFDEAIVCCQRHLDIARELGDKVGQARALYNFGNVYH 155

  Fly   173 AKGKHL--GQRNPGKFGDDVKEALTRAVEFYQENLKLMRDLGDRGAQGRACGNLGNTYYLLGDFQ 235
            ||||.:  ....||.|.:::..||.||.|:|:.||.::::||||.||||..|||||||||||:|:
Zfish   156 AKGKSVCWSGAEPGDFPEEIMTALRRAAEYYEANLCIVKELGDRAAQGRTYGNLGNTYYLLGNFR 220

  Fly   236 AAIEHHQERLRIAREFGDRAAERRANSNLGNSHIFLGQFEDAAEHYKRTLALAVELGEREVEAQS 300
            .|:..|::||.||:|||||:|||||..||||:.||||:||.|||||:|.|.:|.:|.:..||||:
Zfish   221 DAVASHEQRLLIAKEFGDRSAERRAYCNLGNACIFLGEFERAAEHYRRALQIARQLKDLAVEAQA 285

  Fly   301 CYSLGNTYTLLHEFNTAIEYHNRHLAIAQELGDRIGEARACWSLGNAHSAIGGHERALKYAEQHL 365
            ||||||||||:.:|..||:||.:||.|||:|.|||||.||||||||||:|:|.|::|:.:||:||
Zfish   286 CYSLGNTYTLMQDFERAIDYHLKHLIIAQDLNDRIGEGRACWSLGNAHTALGNHDQAMHFAEKHL 350

  Fly   366 QLAKELHDPVGESTARVNISDLRKLLGMPDSEPSPTEEEARSTASDHSASGNQSDGSENSQ---- 426
            :::||..|..||.|||:|:|||:.:||:                   |.|.|.|..|||.:
Zfish   351 EISKETGDRSGELTARMNVSDLQMVLGI-------------------SYSTNNSVLSENKEIDYN 396

  Fly   427 --GRMVRV-RRQSMEQLDLIKITPD-----GK----------------------------RMQEE 455
              |...|: ||.|||.|:|:|:|||     |:                            |.::.
Zfish   397 LHGARPRMSRRHSMENLELLKLTPDKINANGQKWTSDILFKQSKSSLAKSSSKLSFVNRFRGKKH 461

  Fly   456 KLRAQA---------TRKAK-----------DDDFFEMLSRSQSKRMDDQRCSIK-------VN- 492
            ||::.:         ||.|.           |:.||::|||.||.|||||||:|:       ||
Zfish   462 KLQSSSSKILQDTSNTRDAPQSKHGSTDMLGDEGFFDLLSRFQSNRMDDQRCAIQDSKSHLSVNS 526

  Fly   493 -PAGAPAVATGATRKP----------------LVQQNSLFVDP------TNLPGLKS----PSSA 530
             .|..|.......||.                |.......:|.      .:||||::    .|:.
Zfish   527 ISASPPTTPPRTIRKSFSESAASPGQEPFLRLLANAQGRRLDEQRAGTGNSLPGLRTLNEHSSTN 591

  Fly   531 NPSAIGHGPLARSATTTQQPDDDFLDMLMRCQGSRLEEQRSELPRPNVTMDAEAEAPPRSVPEAA 595
            |...|....:|  :|...:|||.|.|||::|||||||:||...|.|:.
Zfish   592 NRQMILSQVMA--STDATEPDDQFFDMLVKCQGSRLEDQRCAPPPPST----------------- 637

  Fly   596 VPGAPRGQTGRGATVPDEDFFSLIMKVQSGRMEDQRASIP 635
                      ||.||||||||||||:.|:.||::||.::|
Zfish   638 ----------RGPTVPDEDFFSLIMRSQAKRMDEQRVTLP 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pins	NP_524999.2	TPR_12	78..153	CDD:290160	52/74 (70%)
		TPR	83..114	CDD:197478	20/30 (67%)
		TPR repeat	83..109	CDD:276809	17/25 (68%)
		TPR repeat	120..150	CDD:276809	24/29 (83%)
		TPR_12	121..203	CDD:290160	51/83 (61%)
		TPR_12	162..250	CDD:290160	51/89 (57%)
		TPR repeat	162..199	CDD:276809	21/38 (55%)
		TPR	219..251	CDD:197478	19/31 (61%)
		TPR repeat	219..246	CDD:276809	16/26 (62%)
		TPR repeat	251..291	CDD:276809	27/39 (69%)
		TPR_12	259..330	CDD:290160	44/70 (63%)
		TPR repeat	296..326	CDD:276809	20/29 (69%)
		TPR_12	298..370	CDD:290160	46/71 (65%)
		TPR	298..330	CDD:197478	21/31 (68%)
		TPR repeat	338..366	CDD:276809	17/27 (63%)
		GoLoco	468..488	CDD:280368	13/19 (68%)
		GoLoco	552..573	CDD:280368	14/20 (70%)
		GoLoco	613..633	CDD:280368	13/19 (68%)
gpsm2	XP_005171423.1	TPR	20..320	CDD:223533	188/293 (64%)
		TPR repeat	29..54	CDD:276809	17/24 (71%)
		TPR repeat	66..92	CDD:276809	17/25 (68%)
		TPR repeat	103..133	CDD:276809	24/29 (83%)
		TPR repeat	144..184	CDD:276809	21/39 (54%)
		TPR repeat	204..231	CDD:276809	16/26 (62%)
		TPR repeat	236..272	CDD:276809	26/35 (74%)
		TPR repeat	283..310	CDD:276809	17/26 (65%)
		TPR_12	287..355	CDD:315987	43/67 (64%)
		TPR repeat	323..351	CDD:276809	17/27 (63%)
		GoLoco	494..513	CDD:308026	12/18 (67%)
		GoLoco	611..632	CDD:308026	14/20 (70%)
		GoLoco	645..666	CDD:308026	13/20 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1130
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56584
Inparanoid	1	1.050	557	1.000	Inparanoid score	I1073
OMA	1	1.010	-	-		QHG45855
OrthoDB	1	1.010	-	-		D321819at33208
OrthoFinder	1	1.000	-	-		FOG0003000
OrthoInspector	1	1.000	-	-		otm25004
orthoMCL	1	0.900	-	-		OOG6_104563
Panther	1	1.100	-	-	O	PTHR45954
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1993
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.840