DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pins and Tonsl

DIOPT Version :9

Sequence 1:NP_524999.2 Gene:pins / 53569 FlyBaseID:FBgn0040080 Length:658 Species:Drosophila melanogaster
Sequence 2:XP_008763809.1 Gene:Tonsl / 366953 RGDID:1307483 Length:1371 Species:Rattus norvegicus


Alignment Length:847 Identity:152/847 - (17%)
Similarity:274/847 - (32%) Gaps:315/847 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    51 ERLC--KAGDCRAGVAFFQAAIQAGTEDLRTLSAIYSQLGNAYFY---------LGDYNKAMQYH 104
            |.:|  :.|:..|....||.|::...::|..|.::...||.|..:         :.:|:.|:::.
  Rat    26 EAVCCHQLGELLASHGRFQEALEEHQQELHLLESVQDTLGCAVAHRKIGERLAEMENYSAALKHQ 90

  Fly   105 KHDLTLAKSMNDRLGEAKSSGNLGNT--------------LKVMGRFDEA--------------- 140
            ...|.||.|:::.....::...:|.|              |:....|:::               
  Rat    91 HLYLDLAGSLSNHTELQRAWATIGRTHLDVYDHCQSRDSLLQAQAAFEKSLAIVDEKLEGMLTQR 155

  Fly   141 -------------AICCE-------------RHLTLARQLGDRLSEG--RALYNLGNVYHAKGKH 177
                         .:.||             :.:.||.|  :.|.|.  ||.||||.::...|:|
  Rat   156 ELSEMRTRLYLNLGLTCESLQQTAQCNNYFKKSIFLAEQ--NHLYEDLFRARYNLGAIHWRGGQH 218

  Fly   178 LGQRNPGKFGDDVKEALTRAVEFYQENLKLMR-----------------DLGDRGAQGRACGNLG 225
                         .:|: |.:|..:|..:.|:                 ||||..|..||.    
  Rat   219 -------------SQAM-RCLEGARECARAMKMRFMESECCMLVSQVLQDLGDFLAAKRAL---- 265

  Fly   226 NTYYLLGD--------------FQAAIEHHQERLRIAREFGDRAAERRANSNLGNSHIFLGQFED 276
            ...|.||.              :..|:...|::|:.| |..|..........||:.......|..
  Rat   266 KKAYRLGSQKPNQRVAICQSLKYVLAVVRLQQQLQEA-EGNDLQGAMAICEQLGDLFSKADDFPK 329

  Fly   277 AAEHYKRTLALAVELGEREVEAQSCY-SLGNTYTLLHEFNTAIEYHNRHLAIAQELGDRIGEARA 340
            |:|.|::.|..|..|...::|....: ||..|...:.:::.|:.::...|.:.:  |:.:.||:.
  Rat   330 ASEAYQKQLHFAELLNRPDLELAVIHESLATTLGDMKDYHKAVHHYEEELRLRK--GNALEEAKT 392

  Fly   341 CWSLGNA---------------HSAIGGHERALKY-----AEQHLQLAKELHDPVGESTARVNIS 385
            .:::|.|               ..|.|..::|.:|     ..|||...:....|.......:.:.
  Rat   393 WFNIGLAREEAGDAYELLAPCFQKAFGCAQQAQRYQLQRQILQHLYTVQLKLQPQEARDTEIRLQ 457

  Fly   386 DLRKLLGMPDSEPSPTEEEARSTAS------DHSASGNQSDG-------SENSQGRMVR------ 431
            :|.......:.|....|||..::.:      :.|.|.:.:||       .|..||.:.|      
  Rat   458 ELSMAKDTEEEEEEEEEEEEEASEALETSEMELSESEDDADGLSQQLEEEEELQGCVGRRKINKL 522

  Fly   432 ----VRRQSMEQLDLIKITPDG--KRMQE----------------------------EKLRAQAT 462
                .||..|.:..|.:...:|  :|:|:                            |.:|....
  Rat   523 HLQWNRRNDMGETLLHRACIEGQLRRVQDLVKQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLD 587

  Fly   463 RKAKDDD------------------------------------------------------FFEM 473
            ..|..||                                                      :|..
  Rat   588 HGAAVDDPGGQGCDGITPLHDALNCGHFEVAELLIERGASVTLRTRKGLSPLETLQQWVKLYFRD 652

  Fly   474 LSRSQSKRMDDQRCSIKVNPAG-----APAVATGATRKPLVQQNSLF---VDPTNLPGLKSPS-- 528
            |.....::.......:::..:|     :||:.|       :..|.||   ..|.:.|..|.||  
  Rat   653 LDLETRQKAASMERRLQMASSGQASHSSPALQT-------IPNNHLFDPETSPPSSPCPKPPSYT 710

  Fly   529 ----SANP-----------SAI------GHGPLARSATTTQQPDDDFLDMLMRCQGSR------L 566
                .|:|           ||:      .|.|.:.|:::   .|||  |....|:.|:      .
  Rat   711 PRPPEASPAPAKVFLEETVSAVCRPRKNRHRPASSSSSS---EDDD--DNTNPCRPSQKRLRHST 770

  Fly   567 EEQRSELPRPNVTMDAEAEAPPRSVPEAA------------VPGAPRGQ----TGRGATVPDEDF 615
            ::..::.|.|:.:.:....:..|:..:||            ||..|||.    ..:.|.:|:|:|
  Rat   771 QQGEAKTPDPSKSRETAISSACRAAYQAAIRGVGSAQSRRLVPSLPRGSNEVPAPKTALIPEEEF 835

  Fly   616 FS 617
            .:
  Rat   836 LA 837

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pinsNP_524999.2 TPR_12 78..153 CDD:290160 18/138 (13%)
TPR 83..114 CDD:197478 8/39 (21%)
TPR repeat 83..109 CDD:276809 5/34 (15%)
TPR repeat 120..150 CDD:276809 6/84 (7%)
TPR_12 121..203 CDD:290160 22/138 (16%)
TPR_12 162..250 CDD:290160 27/118 (23%)
TPR repeat 162..199 CDD:276809 10/36 (28%)
TPR 219..251 CDD:197478 9/45 (20%)
TPR repeat 219..246 CDD:276809 7/40 (18%)
TPR repeat 251..291 CDD:276809 9/39 (23%)
TPR_12 259..330 CDD:290160 15/71 (21%)
TPR repeat 296..326 CDD:276809 5/30 (17%)
TPR_12 298..370 CDD:290160 17/92 (18%)
TPR 298..330 CDD:197478 5/32 (16%)
TPR repeat 338..366 CDD:276809 9/47 (19%)
GoLoco 468..488 CDD:280368 4/73 (5%)
GoLoco 552..573 CDD:280368 5/26 (19%)
GoLoco 613..633 CDD:280368 2/5 (40%)
TonslXP_008763809.1 TPR 3..271 CDD:223533 50/264 (19%)
TPR repeat 27..55 CDD:276809 6/27 (22%)
TPR repeat 66..96 CDD:276809 4/29 (14%)
TPR repeat 101..131 CDD:276809 2/29 (7%)
TPR repeat 163..190 CDD:276809 2/26 (8%)
TPR 187..464 CDD:223533 63/299 (21%)
TPR repeat 195..237 CDD:276809 15/55 (27%)
TPR repeat 242..270 CDD:276809 7/31 (23%)
TPR repeat 316..339 CDD:276809 6/22 (27%)
TPR repeat 351..381 CDD:276809 5/29 (17%)
TPR repeat 390..417 CDD:276809 3/26 (12%)
ANK 527..639 CDD:238125 12/111 (11%)
ANK repeat 532..563 CDD:293786 5/30 (17%)
Ank_2 537..631 CDD:289560 9/93 (10%)
ANK repeat 565..596 CDD:293786 5/30 (17%)
ANK repeat 601..631 CDD:293786 0/29 (0%)
LRR_RI <1059..1315 CDD:238064
leucine-rich repeat 1069..1096 CDD:275380
leucine-rich repeat 1097..1128 CDD:275380
leucine-rich repeat 1129..1151 CDD:275380
leucine-rich repeat 1156..1187 CDD:275380
leucine-rich repeat 1188..1212 CDD:275380
leucine-rich repeat 1213..1246 CDD:275380
leucine-rich repeat 1247..1274 CDD:275380
leucine-rich repeat 1275..1297 CDD:275380
leucine-rich repeat 1298..1325 CDD:275380
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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