DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pins and Gpsm2

DIOPT Version :9

Sequence 1:	NP_524999.2	Gene:	pins / 53569	FlyBaseID:	FBgn0040080	Length:	658	Species:	Drosophila melanogaster
Sequence 2:	NP_001178891.1	Gene:	Gpsm2 / 362021	RGDID:	1560967	Length:	678	Species:	Rattus norvegicus

Alignment Length:	680	Identity:	326/680 - (47%)
Similarity:	434/680 - (63%)	Gaps:	125/680 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 CLELALEGERLCKAGDCRAGVAFFQAAIQAGTEDLRTLSAIYSQLGNAYFYLGDYNKAMQYHKHD 107
            |||||||||||||:|||||||:||:||:|.|||||:||||||||||||||||.||.||::||.||
  Rat    24 CLELALEGERLCKSGDCRAGVSFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLHDYAKALEYHHHD 88

  Fly   108 LTLAKSMNDRLGEAKSSGNLGNTLKVMGRFDEAAICCERHLTLARQLGDRLSEGRALYNLGNVYH 172
            ||||:::.|:|||||:||||||||||:|.||||.:||:|||.::|:|.|::.|.|||||||||||
  Rat    89 LTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLGNVYH 153

  Fly   173 AKGKHLGQRNP---GKFGDDVKEALTRAVEFYQENLKLMRDLGDRGAQGRACGNLGNTYYLLGDF 234
            ||||..|...|   |:|.::|:.||..|||.|:|||.|:..||||.|||||.||||||:||||:|
  Rat   154 AKGKSFGCPGPQDVGEFPEEVRLALQAAVELYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNF 218

  Fly   235 QAAIEHHQERLRIAREFGDRAAERRANSNLGNSHIFLGQFEDAAEHYKRTLALAVELGEREVEAQ 299
            :.|:..|::||.||:||||:||||||.|||||::||||:||.|:|:|::||.||.:|.:|.||||
  Rat   219 RDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYRKTLLLARQLKDRAVEAQ 283

  Fly   300 SCYSLGNTYTLLHEFNTAIEYHNRHLAIAQELGDRIGEARACWSLGNAHSAIGGHERALKYAEQH 364
            ||||||||||||.::..|||||.:||||||||.|||||.|||||||||::|:|.|::|:.:||:|
  Rat   284 SCYSLGNTYTLLQDYEKAIEYHLKHLAIAQELKDRIGEGRACWSLGNAYTALGNHDQAMHFAEKH 348

  Fly   365 LQLAKELHDPVGESTARVNISDLRKLLGMPDSEPSPTEEEARSTASDHSASGNQSDGSENSQGRM 429
            |::::|:.|..||.|||:|:|||:.:||:           :.||.:...:...:.|||.:..|..
  Rat   349 LEISREVGDKSGELTARLNLSDLQMVLGL-----------SYSTNNSMMSENIEIDGSLHGAGTK 402

  Fly   430 VRVRRQSMEQLDLIKITPD-------------------------------GKRMQEEKLRAQATR 463
            :. ||.|||.::|:|:||:                               ||:.:......:|..
  Rat   403 LG-RRHSMENMELMKLTPEKVPNWNSEILAKQKPCIAKSSAKLLFVNRLKGKKSKSGSASTKALH 466

  Fly   464 KAK--------------------DDDFFEMLSRSQSKRMDDQRCSIKVNPAGAPAVATGATRKPL 508
            .|.                    |:.||::|.|.||.||:||||.::.|.. |...|:.||.|.:
  Rat   467 HASNPIDHRAPHAQKKVGSDAVGDEGFFDLLRRLQSSRMEDQRCHLQENRT-ASVAASSATPKMV 530

  Fly   509 VQQNSLFVDP------------------------TNLPGLKSPSSANPSAIGHGPLARSATT-TQ 548
            ...::..|.|                        :|||||:.....|.|.     |.|..|. .:
  Rat   531 KAPSASVVSPNTDEFLDLLASSQSRRLDDQRASFSNLPGLRLTEGNNQSV-----LERLMTNDKK 590

  Fly   549 QPDDDFLDMLMRCQGSRLEEQRSELPRPNVTMDAEAEAPPRSVPEAAVPGAPRGQTGRGATVPDE 613
            :||:||.|:|::||||||::||.              |||        |.|.     :|.|||||
  Rat   591 EPDEDFFDILVKCQGSRLDDQRC--------------APP--------PAAT-----KGPTVPDE 628

  Fly   614 DFFSLIMKVQSGRMEDQRASIPFRNANNNN 643
            ||||||::.|:.||::||..:. |:.|.::
  Rat   629 DFFSLILRSQAKRMDEQRVLLQ-RDPNRDS 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pins	NP_524999.2	TPR_12	78..153	CDD:290160	54/74 (73%)
		TPR	83..114	CDD:197478	24/30 (80%)
		TPR repeat	83..109	CDD:276809	20/25 (80%)
		TPR repeat	120..150	CDD:276809	23/29 (79%)
		TPR_12	121..203	CDD:290160	52/84 (62%)
		TPR_12	162..250	CDD:290160	56/90 (62%)
		TPR repeat	162..199	CDD:276809	23/39 (59%)
		TPR	219..251	CDD:197478	19/31 (61%)
		TPR repeat	219..246	CDD:276809	16/26 (62%)
		TPR repeat	251..291	CDD:276809	27/39 (69%)
		TPR_12	259..330	CDD:290160	48/70 (69%)
		TPR repeat	296..326	CDD:276809	22/29 (76%)
		TPR_12	298..370	CDD:290160	49/71 (69%)
		TPR	298..330	CDD:197478	24/31 (77%)
		TPR repeat	338..366	CDD:276809	16/27 (59%)
		GoLoco	468..488	CDD:280368	11/19 (58%)
		GoLoco	552..573	CDD:280368	12/20 (60%)
		GoLoco	613..633	CDD:280368	12/19 (63%)
Gpsm2	NP_001178891.1	TPR	<27..286	CDD:223533	176/258 (68%)
		TPR repeat	27..52	CDD:276809	21/24 (88%)
		TPR repeat	64..90	CDD:276809	20/25 (80%)
		TPR repeat	101..131	CDD:276809	23/29 (79%)
		TPR repeat	203..230	CDD:276809	16/26 (62%)
		TPR_12	243..314	CDD:315987	48/70 (69%)
		TPR repeat	243..270	CDD:276809	17/26 (65%)
		TPR repeat	281..311	CDD:276809	22/29 (76%)
		TPR_12	286..354	CDD:315987	45/67 (67%)
		TPR repeat	322..350	CDD:276809	16/27 (59%)
		GoLoco	490..512	CDD:214645	13/21 (62%)
		GoLoco	543..562	CDD:396661	0/18 (0%)
		GoLoco	594..613	CDD:396661	11/18 (61%)
		GoLoco	627..649	CDD:214645	13/21 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I11728
eggNOG	1	0.900	-	-		E1_KOG1130
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56584
Inparanoid	1	1.050	579	1.000	Inparanoid score	I991
OMA	1	1.010	-	-		QHG45855
OrthoDB	1	1.010	-	-		D321819at33208
OrthoFinder	1	1.000	-	-		FOG0003000
OrthoInspector	1	1.000	-	-		otm46358
orthoMCL	1	0.900	-	-		OOG6_104563
Panther	1	1.100	-	-	O	PTHR45954
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1993
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840