DRSC/TRiP Functional Genomics Resources

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Protein Alignment pins and Ttc28

DIOPT Version :9

Sequence 1:NP_524999.2 Gene:pins / 53569 FlyBaseID:FBgn0040080 Length:658 Species:Drosophila melanogaster
Sequence 2:XP_006249646.1 Gene:Ttc28 / 304558 RGDID:1594541 Length:2451 Species:Rattus norvegicus


Alignment Length:727 Identity:185/727 - (25%)
Similarity:291/727 - (40%) Gaps:190/727 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 GNSQQGSGSDGGSSMCLELALE-GERLCKAGDCRA----GVAFF--------------QAAIQAG 73
            ||:::   |.|.....|::|.. |:   :.|:|||    |.|||              |..:...
  Rat   242 GNTEK---STGYMQQDLDVAKTLGD---QTGECRAHGNLGSAFFSKGNYREALTNHRHQLVLAMK 300

  Fly    74 TEDLRTLSAIYSQLGNAYFYLGDYNKAMQYHKHDLTLAKSMNDRLGEAKSSGNLGNTLKVMGRFD 138
            .:|....|:..|.||:.|..:|||..|:..||..:.|||...|.|.||:..||:|.....||.|:
  Rat   301 LKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDDLSEARELGNMGAVYIAMGDFE 365

  Fly   139 EAAICCERHLTLARQLGDRLSEGRALYNLGNVYHAK---------------------GKHLGQRN 182
            .|..|.|:||.:|:.||.:..|.||..|||:.||.:                     .|.:..|.
  Rat   366 NAVQCHEQHLRIAKDLGSKREEARAYSNLGSAYHYRRNFDKAMSYHNCVLELAQELTEKPIEMRA 430

  Fly   183 PGKFGDDVK--EALTRAVEFYQENLKLMRDLGDRGAQGRACGNLGNTYYLLGDFQAAIEHHQERL 245
            ....|...:  :.|.||.:::::.|.:..||.||.|:|||..|||..:.:.||:..|::.|:..|
  Rat   431 YAGLGHAARCMQDLERARQYHEQQLSIAEDLKDRAAEGRASSNLGIIHQMKGDYDTALKLHKTHL 495

  Fly   246 RIAREFGDRAAERRANSNLGNSHIFLGQFEDAA-------------------------------- 278
            .||:|..|.||:.||..|:||::..||.::.|.                                
  Rat   496 CIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQA 560

  Fly   279 --------EHYKRTLALAVELGEREVEAQSCYSLGNTYTLLHEFNTAIEYHNRHLAIAQELGDRI 335
                    :||:..|.:|.||.:.:.||::..:|||.:....|:..|..|:.::|.:|.:|.|..
  Rat   561 LGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDME 625

  Fly   336 GEARACWSLGNAHSAIGGHERALKYAEQHLQLAKELHDPVGESTARVNIS-DLRKLLGMPDSEPS 399
            ||.:.|.:||.||..:|.::.|:||.||.|.|||:|||.:.::.|..|:. ..:.||....:|..
  Rat   626 GEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFTKAEEC 690

  Fly   400 PTEEEARSTASDHS-----ASGNQSDGSENSQGRMVRVRRQSMEQLDLIKITPDGK-RMQEEKLR 458
            .....:.:.:.|:|     |.||..|                   :.:.|...:|. :..|::| 
  Rat   691 QKYLLSLAQSLDNSQAKFRALGNLGD-------------------IFVCKKDVNGAIKFYEQQL- 735

  Fly   459 AQATRKAKDDDFFEMLSRSQSKRMDDQRCSIKVNPAGAPAVATGATRKPLV-----------QQN 512
                              ..|..:.|:|..       |.|.|...|...:|           |:.
  Rat   736 ------------------GLSHHVKDRRLE-------ASAYAALGTAYRMVQKYDKALGYHTQEL 775

  Fly   513 SLFVDPTNLPGLKSPSSANPSAIGHGPLARSATTTQQPDDDFLDMLMRCQGSRLEEQRSELPRPN 577
            .::.:.::|||         ....||.||.......:     ..|..:|...:||..| :|..|:
  Rat   776 EVYQELSDLPG---------ECRAHGHLAAVYMALGK-----YTMAFKCYQEQLELGR-KLKEPS 825

  Fly   578 VTMDAEAEAPPRSVPEAAVPGAPRGQTGRGATVPDEDFFSLIMKVQSGRMEDQRASIPFRNANNN 642
            :              ||.|.| ..|.|.....|.::..         |..|.|.|.:...:.|.:
  Rat   826 L--------------EAQVYG-NMGITKMNMNVVEDAI---------GYFEQQLAMLQQLSGNES 866

  Fly   643 NNSRSNNNGSAG 654
            ...|....|:.|
  Rat   867 VLDRGRAYGNLG 878

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pinsNP_524999.2 TPR_12 78..153 CDD:290160 30/74 (41%)
TPR 83..114 CDD:197478 13/30 (43%)
TPR repeat 83..109 CDD:276809 10/25 (40%)
TPR repeat 120..150 CDD:276809 13/29 (45%)
TPR_12 121..203 CDD:290160 29/104 (28%)
TPR_12 162..250 CDD:290160 32/110 (29%)
TPR repeat 162..199 CDD:276809 13/59 (22%)
TPR 219..251 CDD:197478 12/31 (39%)
TPR repeat 219..246 CDD:276809 9/26 (35%)
TPR repeat 251..291 CDD:276809 15/79 (19%)
TPR_12 259..330 CDD:290160 24/110 (22%)
TPR repeat 296..326 CDD:276809 8/29 (28%)
TPR_12 298..370 CDD:290160 27/71 (38%)
TPR 298..330 CDD:197478 9/31 (29%)
TPR repeat 338..366 CDD:276809 11/27 (41%)
GoLoco 468..488 CDD:280368 3/19 (16%)
GoLoco 552..573 CDD:280368 5/20 (25%)
GoLoco 613..633 CDD:280368 3/19 (16%)
Ttc28XP_006249646.1 TPR_11 57..117 CDD:290150
TPR repeat 85..115 CDD:276809
TPR_11 88..151 CDD:290150
TPR repeat 120..148 CDD:276809
TPR repeat 154..182 CDD:276809
TPR repeat 230..256 CDD:276809 4/16 (25%)
TPR repeat 268..300 CDD:276809 8/31 (26%)
TPR_11 269..339 CDD:290150 20/69 (29%)
TPR repeat 305..337 CDD:276809 11/31 (35%)
TPR_12 309..380 CDD:290160 29/70 (41%)
TPR repeat 348..376 CDD:276809 11/27 (41%)
TPR_7 351..385 CDD:289919 14/33 (42%)
TPR 373..687 CDD:223533 92/313 (29%)
TPR repeat 387..417 CDD:276809 8/29 (28%)
TPR 388..420 CDD:197478 7/31 (23%)
TPR repeat 428..456 CDD:276809 5/27 (19%)
TPR repeat 469..496 CDD:276809 9/26 (35%)
TPR repeat 509..536 CDD:276809 8/26 (31%)
TPR_7 510..545 CDD:289919 7/34 (21%)
TPR repeat 548..576 CDD:276809 2/27 (7%)
TPR repeat 588..616 CDD:276809 7/27 (26%)
TPR_7 590..625 CDD:289919 10/34 (29%)
TPR repeat 627..657 CDD:276809 13/29 (45%)
TPR_7 630..664 CDD:289919 17/33 (52%)
TPR 688..989 CDD:223533 49/275 (18%)
TPR repeat 706..733 CDD:276809 6/45 (13%)
TPR repeat 748..776 CDD:276809 6/27 (22%)
TPR 788..817 CDD:197478 7/33 (21%)
TPR repeat 788..816 CDD:276809 6/32 (19%)
TPR repeat 827..857 CDD:276809 10/39 (26%)
TPR repeat 872..899 CDD:276809 2/7 (29%)
TPR_7 873..905 CDD:289919 2/6 (33%)
TPR repeat 910..944 CDD:276809
TPR repeat 951..976 CDD:276809
TPR_7 953..988 CDD:289919
TPR repeat 991..1019 CDD:276809
TPR_12 993..1061 CDD:290160
TPR repeat 1031..1059 CDD:276809
TPR_12 1032..1103 CDD:290160
TPR repeat 1069..1099 CDD:276809
TPR_11 1072..1140 CDD:290150
TPR repeat 1111..1137 CDD:276809
TPR repeat 1163..1188 CDD:276809
CHAT 1384..1707 CDD:289536
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1130
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D321819at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

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