DRSC/TRiP Functional Genomics Resources

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Protein Alignment pins and GPSM2

DIOPT Version :10

Sequence 1:NP_524999.2 Gene:pins / 53569 FlyBaseID:FBgn0040080 Length:658 Species:Drosophila melanogaster
Sequence 2:NP_037428.3 Gene:GPSM2 / 29899 HGNCID:29501 Length:684 Species:Homo sapiens


Alignment Length:688 Identity:323/688 - (46%)
Similarity:437/688 - (63%) Gaps:138/688 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 CLELALEGERLCKAGDCRAGVAFFQAAIQAGTEDLRTLSAIYSQLGNAYFYLGDYNKAMQYHKHD 107
            |||||||||||||:|||||||:||:||:|.|||||:||||||||||||||||.||.||::||.||
Human    24 CLELALEGERLCKSGDCRAGVSFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLHDYAKALEYHHHD 88

  Fly   108 LTLAKSMNDRLGEAKSSGNLGNTLKVMGRFDEAAICCERHLTLARQLGDRLSEGRALYNLGNVYH 172
            ||||:::.|:|||||:||||||||||:|.||||.:||:|||.::|:|.|::.|.|||||||||||
Human    89 LTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLGNVYH 153

  Fly   173 AKGKHLGQRNP---GKFGDDVKEALTRAVEFYQENLKLMRDLGDRGAQGRACGNLGNTYYLLGDF 234
            ||||..|...|   |:|.::|::||..||:||:|||.|:..||||.|||||.||||||:||||:|
Human   154 AKGKSFGCPGPQDVGEFPEEVRDALQAAVDFYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNF 218

  Fly   235 QAAIEHHQERLRIAREFGDRAAERRANSNLGNSHIFLGQFEDAAEHYKRTLALAVELGEREVEAQ 299
            :.|:..|::||.||:||||:||||||.|||||::||||:||.|:|:||:||.||.:|.:|.||||
Human   219 RDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKTLLLARQLKDRAVEAQ 283

  Fly   300 SCYSLGNTYTLLHEFNTAIEYHNRHLAIAQELGDRIGEARACWSLGNAHSAIGGHERALKYAEQH 364
            ||||||||||||.::..||:||.:||||||||.|||||.|||||||||::|:|.|::|:.:||:|
Human   284 SCYSLGNTYTLLQDYEKAIDYHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKH 348

  Fly   365 LQLAKELHDPVGESTARVNISDLRKLLGMPDSEPSPTEEEARSTASDHSASGNQSDGSENSQ--- 426
            |::::|:.|..||.|||:|:|||:.:||:                   |.|.|.|..|||::   
Human   349 LEISREVGDKSGELTARLNLSDLQMVLGL-------------------SYSTNNSIMSENTEIDS 394

  Fly   427 ---GRMVRV-RRQSMEQLDLIKITPDG--------------------------KRMQEEKLRAQA 461
               |...:: ||.|||.::|:|:||:.                          .|::.:|.:..:
Human   395 SLNGVRPKLGRRHSMENMELMKLTPEKVQNWNSEILAKQKPLIAKPSAKLLFVNRLKGKKYKTNS 459

  Fly   462 TRKA------------------------KDDDFFEMLSRSQSKRMDDQRCSIKVNPAGAPAVATG 502
            :.|.                        .|:.||::|||.||.|||||||.::.......:..|.
Human   460 STKVLQDASNSIDHRIPNSQRKISADTIGDEGFFDLLSRFQSNRMDDQRCCLQEKNCHTASTTTS 524

  Fly   503 AT---------RKPLVQQNS-LFVDP----------------TNLPGLKSPSSANPSAIGHGPLA 541
            :|         ..|:|..|: .|:|.                :|||||:...::. |.:.|    
Human   525 STPPKMMLKTSSVPVVSPNTDEFLDLLASSQSRRLDDQRASFSNLPGLRLTQNSQ-SVLSH---- 584

  Fly   542 RSATTTQQPDDDFLDMLMRCQGSRLEEQRSELPRPNVTMDAEAEAPPRSVPEAAVPGAPRGQTGR 606
            ......::.|:||.|:|::||||||::||.              |||.:             |.:
Human   585 LMTNDNKEADEDFFDILVKCQGSRLDDQRC--------------APPPA-------------TTK 622

  Fly   607 GATVPDEDFFSLIMKVQSGRMEDQRASIPFRNANNNNN 644
            |.|||||||||||::.|..||::||..:. |:.|.:.:
Human   623 GPTVPDEDFFSLILRSQGKRMDEQRVLLQ-RDQNRDTD 659

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pinsNP_524999.2 TPR 50..261 CDD:440225 146/213 (69%)
TPR repeat 83..109 CDD:276809 20/25 (80%)
TPR repeat 120..150 CDD:276809 23/29 (79%)
TPR 162..>373 CDD:440225 138/213 (65%)
TPR repeat 162..199 CDD:276809 23/39 (59%)
TPR repeat 219..246 CDD:276809 16/26 (62%)
TPR repeat 251..291 CDD:276809 28/39 (72%)
TPR repeat 296..326 CDD:276809 21/29 (72%)
TPR repeat 338..366 CDD:276809 16/27 (59%)
GoLoco 468..488 CDD:460481 13/19 (68%)
GoLoco 552..573 CDD:460481 12/20 (60%)
GoLoco 613..633 CDD:460481 12/19 (63%)
GPSM2NP_037428.3 Important for interaction with NUMA1, INSC and FRMPD1. /evidence=ECO:0000250|UniProtKB:Q8VDU0 22..357 226/332 (68%)
TPR repeat 27..52 CDD:276809 21/24 (88%)
TPR repeat 64..90 CDD:276809 20/25 (80%)
TPR 65..335 CDD:440225 182/269 (68%)
TPR repeat 101..131 CDD:276809 23/29 (79%)
TPR repeat 203..230 CDD:276809 16/26 (62%)
TPR repeat 243..270 CDD:276809 18/26 (69%)
TPR repeat 281..311 CDD:276809 21/29 (72%)
TPR repeat 322..350 CDD:276809 16/27 (59%)
TPR_7 324..359 CDD:433012 18/34 (53%)
GoLoco 490..511 CDD:460481 14/20 (70%)
GoLoco 545..566 CDD:460481 2/20 (10%)
GoLoco 594..616 CDD:214645 13/35 (37%)
GoLoco 629..650 CDD:460481 12/20 (60%)

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