DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pins and GPSM2

DIOPT Version :9

Sequence 1:	NP_524999.2	Gene:	pins / 53569	FlyBaseID:	FBgn0040080	Length:	658	Species:	Drosophila melanogaster
Sequence 2:	NP_001307967.1	Gene:	GPSM2 / 29899	HGNCID:	29501	Length:	684	Species:	Homo sapiens

Alignment Length:	688	Identity:	323/688 - (46%)
Similarity:	437/688 - (63%)	Gaps:	138/688 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 CLELALEGERLCKAGDCRAGVAFFQAAIQAGTEDLRTLSAIYSQLGNAYFYLGDYNKAMQYHKHD 107
            |||||||||||||:|||||||:||:||:|.|||||:||||||||||||||||.||.||::||.||
Human    24 CLELALEGERLCKSGDCRAGVSFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLHDYAKALEYHHHD 88

  Fly   108 LTLAKSMNDRLGEAKSSGNLGNTLKVMGRFDEAAICCERHLTLARQLGDRLSEGRALYNLGNVYH 172
            ||||:::.|:|||||:||||||||||:|.||||.:||:|||.::|:|.|::.|.|||||||||||
Human    89 LTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLGNVYH 153

  Fly   173 AKGKHLGQRNP---GKFGDDVKEALTRAVEFYQENLKLMRDLGDRGAQGRACGNLGNTYYLLGDF 234
            ||||..|...|   |:|.::|::||..||:||:|||.|:..||||.|||||.||||||:||||:|
Human   154 AKGKSFGCPGPQDVGEFPEEVRDALQAAVDFYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNF 218

  Fly   235 QAAIEHHQERLRIAREFGDRAAERRANSNLGNSHIFLGQFEDAAEHYKRTLALAVELGEREVEAQ 299
            :.|:..|::||.||:||||:||||||.|||||::||||:||.|:|:||:||.||.:|.:|.||||
Human   219 RDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKTLLLARQLKDRAVEAQ 283

  Fly   300 SCYSLGNTYTLLHEFNTAIEYHNRHLAIAQELGDRIGEARACWSLGNAHSAIGGHERALKYAEQH 364
            ||||||||||||.::..||:||.:||||||||.|||||.|||||||||::|:|.|::|:.:||:|
Human   284 SCYSLGNTYTLLQDYEKAIDYHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKH 348

  Fly   365 LQLAKELHDPVGESTARVNISDLRKLLGMPDSEPSPTEEEARSTASDHSASGNQSDGSENSQ--- 426
            |::::|:.|..||.|||:|:|||:.:||:                   |.|.|.|..|||::
Human   349 LEISREVGDKSGELTARLNLSDLQMVLGL-------------------SYSTNNSIMSENTEIDS 394

  Fly   427 ---GRMVRV-RRQSMEQLDLIKITPDG--------------------------KRMQEEKLRAQA 461
               |...:: ||.|||.::|:|:||:.                          .|::.:|.:..:
Human   395 SLNGVRPKLGRRHSMENMELMKLTPEKVQNWNSEILAKQKPLIAKPSAKLLFVNRLKGKKYKTNS 459

  Fly   462 TRKA------------------------KDDDFFEMLSRSQSKRMDDQRCSIKVNPAGAPAVATG 502
            :.|.                        .|:.||::|||.||.|||||||.::.......:..|.
Human   460 STKVLQDASNSIDHRIPNSQRKISADTIGDEGFFDLLSRFQSNRMDDQRCCLQEKNCHTASTTTS 524

  Fly   503 AT---------RKPLVQQNS-LFVDP----------------TNLPGLKSPSSANPSAIGHGPLA 541
            :|         ..|:|..|: .|:|.                :|||||:...::. |.:.|
Human   525 STPPKMMLKTSSVPVVSPNTDEFLDLLASSQSRRLDDQRASFSNLPGLRLTQNSQ-SVLSH---- 584

  Fly   542 RSATTTQQPDDDFLDMLMRCQGSRLEEQRSELPRPNVTMDAEAEAPPRSVPEAAVPGAPRGQTGR 606
            ......::.|:||.|:|::||||||::||.              |||.:             |.:
Human   585 LMTNDNKEADEDFFDILVKCQGSRLDDQRC--------------APPPA-------------TTK 622

  Fly   607 GATVPDEDFFSLIMKVQSGRMEDQRASIPFRNANNNNN 644
            |.|||||||||||::.|..||::||..:. |:.|.:.:
Human   623 GPTVPDEDFFSLILRSQGKRMDEQRVLLQ-RDQNRDTD 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pins	NP_524999.2	TPR_12	78..153	CDD:290160	54/74 (73%)
		TPR	83..114	CDD:197478	24/30 (80%)
		TPR repeat	83..109	CDD:276809	20/25 (80%)
		TPR repeat	120..150	CDD:276809	23/29 (79%)
		TPR_12	121..203	CDD:290160	52/84 (62%)
		TPR_12	162..250	CDD:290160	56/90 (62%)
		TPR repeat	162..199	CDD:276809	23/39 (59%)
		TPR	219..251	CDD:197478	19/31 (61%)
		TPR repeat	219..246	CDD:276809	16/26 (62%)
		TPR repeat	251..291	CDD:276809	28/39 (72%)
		TPR_12	259..330	CDD:290160	48/70 (69%)
		TPR repeat	296..326	CDD:276809	21/29 (72%)
		TPR_12	298..370	CDD:290160	48/71 (68%)
		TPR	298..330	CDD:197478	23/31 (74%)
		TPR repeat	338..366	CDD:276809	16/27 (59%)
		GoLoco	468..488	CDD:280368	13/19 (68%)
		GoLoco	552..573	CDD:280368	12/20 (60%)
		GoLoco	613..633	CDD:280368	12/19 (63%)
GPSM2	NP_001307967.1	Important for interaction with NUMA1, INSC and FRMPD1. /evidence=ECO:0000250\|UniProtKB:Q8VDU0	22..357		226/332 (68%)
		TPR repeat	27..52	CDD:276809	21/24 (88%)
		TPR_12	63..134	CDD:290160	51/70 (73%)
		TPR repeat	64..90	CDD:276809	20/25 (80%)
		TPR repeat	101..131	CDD:276809	23/29 (79%)
		TPR_1	102..131	CDD:278916	22/28 (79%)
		TPR_12	142..234	CDD:290160	56/91 (62%)
		TPR repeat	203..230	CDD:276809	16/26 (62%)
		TPR_12	243..314	CDD:290160	48/70 (69%)
		TPR_1	243..274	CDD:278916	21/30 (70%)
		TPR repeat	243..270	CDD:276809	18/26 (69%)
		TPR repeat	281..311	CDD:276809	21/29 (72%)
		TPR_12	282..354	CDD:290160	48/71 (68%)
		TPR_7	284..318	CDD:289919	24/33 (73%)
		TPR repeat	322..350	CDD:276809	16/27 (59%)
		TPR_7	324..359	CDD:289919	18/34 (53%)
		GoLoco	489..511	CDD:214645	15/21 (71%)
		GoLoco	545..566	CDD:280368	2/20 (10%)
		GoLoco	594..616	CDD:214645	13/35 (37%)
		GoLoco	629..650	CDD:280368	12/20 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11771
eggNOG	1	0.900	-	-		E1_KOG1130
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56584
Inparanoid	1	1.050	568	1.000	Inparanoid score	I1075
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45855
OrthoDB	1	1.010	-	-		D321819at33208
OrthoFinder	1	1.000	-	-		FOG0003000
OrthoInspector	1	1.000	-	-		otm42207
orthoMCL	1	0.900	-	-		OOG6_104563
Panther	1	1.100	-	-	O	PTHR45954
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1993
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.840