Protein Alignment pins and GPSM1

DIOPT Version :10

• Sequence 1: NP_524999.2
• Gene: pins / 53569
• FlyBaseID: FBgn0040080
• Length: 658
• Species: Drosophila melanogaster
• Sequence 2: NP_001139110.2
• Gene: GPSM1 / 26086
• HGNCID: 17858
• Length: 675
• Species: Homo sapiens
• Alignment Length: 696
• Identity: 312/696 - (44%)
• Similarity: 417/696 - (59%)
• Gaps: 143/696 - (20%)

  Fly    43 CLELALEGERLCKAGDCRAGVAFFQAAIQAGTEDLRTLSAIYSQLGNAYFYLGDYNKAMQYHKHD 107
            ||||||||||||||||.:.|||||:||:|.|||||:||||||||||||||||.::.:|::|||||
Human    28 CLELALEGERLCKAGDFKTGVAFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLKEHGRALEYHKHD 92

  Fly   108 LTLAKSMNDRLGEAKSSGNLGNTLKVMGRFDEAAICCERHLTLARQLGDRLSEGRALYNLGNVYH 172
            |.||:::.||:||||:||||||||||:|||||||:||:|||::|::.||::.|.|||||:|||||
Human    93 LLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYH 157

  Fly   173 AKGKHL------GQRNPGKFGDDVKEALTRAVEFYQENLKLMRDLGDRGAQGRACGNLGNTYYLL 231
            ||||.|      ..::||....||:|.|.:|.|||:.||.|:::||||.|||||.||||||:|||
Human   158 AKGKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLL 222

  Fly   232 GDFQAAIEHHQERLRIAREFGDRAAERRANSNLGNSHIFLGQFEDAAEHYKRTLALAVELGEREV 296
            |:|..|...|:|||.||:||||:||||||.|||||:|:|||:|:.|||:||:||.|:.:|.::.|
Human   223 GNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAV 287

  Fly   297 EAQSCYSLGNTYTLLHEFNTAIEYHNRHLAIAQELGDRIGEARACWSLGNAHSAIGGHERALKYA 361
            |||:|||||||||||.::..|.|||.|||.|||||.||:||.|||||||||:.::|...:||.:|
Human   288 EAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFA 352

  Fly   362 EQHLQLAKELHDPVGESTARVNISDLRKLLGMPDSEPSPTEEEARSTASDHSASGNQSDGSENSQ 426
            ::|||:::|:.|..||.|||:|::.|:.:||...| |:.:|:.        ..:|.::.|:
Human   353 KKHLQISQEIGDRHGELTARMNVAQLQLVLGRLTS-PAASEKP--------DLAGYEAQGA---- 404

  Fly   427 GRMVRVRRQSMEQLDLIKIT-----------------------------------PDGKRMQEE- 455
             |..|.:|.|.|..||:::.                                   ||.:|...|
Human   405 -RPKRTQRLSAETWDLLRLPLEREQNGDSHHSGDWRGPSRDSLPLPVRSRKYQEGPDAERRPREG 468

  Fly   456 --------KLRAQATR----KAKDDD---FFEMLSRSQSKRMDDQRCSIKVNPAGAPAVATGATR 505
                    .:|....|    :|...|   ||::|::.||.|||||||.:....|||.......|.
Human   469 SHSPLDSADVRVHVPRTSIPRAPSSDEECFFDLLTKFQSSRMDDQRCPLDDGQAGAAEATAAPTL 533

  Fly   506 KPLVQQNSLFVDPT------------------------NLPGLKSPSSANPSAIGHGPLARSATT 546
            :..:.|.|:...|.                        :||||:...|......|||       .
Human   534 EDRIAQPSMTASPQTEEFFDLIASSQSRRLDDQRASVGSLPGLRITHSNAGHLRGHG-------E 591

  Fly   547 TQQPDDDFLDMLMRCQGSRLEEQRSELPRPNVTMDAEAEAPPRSVPEAAVPGAPRGQTGRGATVP 611
            .|:|.|||.:||::.|.||:::||.              .||..:|             ||.|:|
Human   592 PQEPGDDFFNMLIKYQSSRIDDQRC--------------PPPDVLP-------------RGPTMP 629

  Fly   612 DEDFFSLIMKVQSGRMEDQRASIPFRNANNNNNSRSNNNGSAGGAG 657
            ||||||||.:||:.||::||..:.              .|...|||
Human   630 DEDFFSLIQRVQAKRMDEQRVDLA--------------GGPEQGAG 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pins	NP_524999.2	TPR	50..261	CDD:440225	143/216 (66%)
		TPR repeat	83..109	CDD:276809	18/25 (72%)
		TPR repeat	120..150	CDD:276809	25/29 (86%)
		TPR	162..>373	CDD:440225	132/216 (61%)
		TPR repeat	162..199	CDD:276809	22/42 (52%)
		TPR repeat	219..246	CDD:276809	17/26 (65%)
		TPR repeat	251..291	CDD:276809	27/39 (69%)
		TPR repeat	296..326	CDD:276809	21/29 (72%)
		TPR repeat	338..366	CDD:276809	14/27 (52%)
		GoLoco	468..488	CDD:460481	12/22 (55%)
		GoLoco	552..573	CDD:460481	10/20 (50%)
		GoLoco	613..633	CDD:460481	13/19 (68%)
GPSM1	NP_001139110.2	Mediates association with membranes. /evidence=ECO:0000250	1..509		253/494 (51%)
		TPR repeat	31..56	CDD:276809	20/24 (83%)
		TPR repeat	68..94	CDD:276809	18/25 (72%)
		TPR	69..325	CDD:440225	163/255 (64%)
		TPR repeat	105..135	CDD:276809	25/29 (86%)
		TPR	210..464	CDD:440225	121/267 (45%)
		TPR repeat	210..237	CDD:276809	17/26 (65%)
		TPR repeat	250..277	CDD:276809	18/26 (69%)
		TPR repeat	288..318	CDD:276809	21/29 (72%)
		TPR repeat	323..357	CDD:276809	18/33 (55%)
		Interaction with STK11/LKB1. /evidence=ECO:0000250	364..487		28/136 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	391..412		5/33 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	424..492		7/67 (10%)
		GoLoco	496..517	CDD:460481	12/20 (60%)
		GoLoco	549..569	CDD:460481	0/19 (0%)
		GoLoco	597..617	CDD:460481	10/33 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	610..630		9/46 (20%)
		GoLoco	631..652	CDD:460481	13/20 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	644..675		8/32 (25%)