DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pins and Ttc28

DIOPT Version :9

Sequence 1:NP_524999.2 Gene:pins / 53569 FlyBaseID:FBgn0040080 Length:658 Species:Drosophila melanogaster
Sequence 2:NP_001254551.1 Gene:Ttc28 / 209683 MGIID:2140873 Length:2450 Species:Mus musculus


Alignment Length:727 Identity:185/727 - (25%)
Similarity:293/727 - (40%) Gaps:190/727 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 GNSQQGSGSDGGSSMCLELALE-GERLCKAGDCRA----GVAFF--------------QAAIQAG 73
            ||:::   |.|.....|::|.. |:   :.|:|||    |.|||              |..:...
Mouse   242 GNTEK---STGYMQQDLDVAKTLGD---QTGECRAHGNLGSAFFSKGNYREALTNHRHQLVLAMK 300

  Fly    74 TEDLRTLSAIYSQLGNAYFYLGDYNKAMQYHKHDLTLAKSMNDRLGEAKSSGNLGNTLKVMGRFD 138
            .:|....|:..|.||:.|..:|||..|:..||..:.|||...|.|.||:..||:|.....||.|:
Mouse   301 LKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDDLSEARELGNMGAVYIAMGDFE 365

  Fly   139 EAAICCERHLTLARQLGDRLSEGRALYNLGNVYHAK---------------------GKHLGQRN 182
            .|..|.|:||.:|:.||.:..|.||..|||:.||.:                     .|.:..|.
Mouse   366 NAVQCHEQHLRIAKDLGSKREEARAYSNLGSAYHYRRNFDKAMSYHNCVLELAQELMEKPIEMRA 430

  Fly   183 PGKFGDDVK--EALTRAVEFYQENLKLMRDLGDRGAQGRACGNLGNTYYLLGDFQAAIEHHQERL 245
            ....|...:  :.|.||.:::::.|.:..||.||.|:|||..|||..:.:.||:..|::.|:..|
Mouse   431 YAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQMKGDYDTALKLHKTHL 495

  Fly   246 RIAREFGDRAAERRANSNLGNSHIFLGQFEDAA-------------------------------- 278
            .||:|..|.||:.||..|:||::..||.::.|.                                
Mouse   496 CIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQA 560

  Fly   279 --------EHYKRTLALAVELGEREVEAQSCYSLGNTYTLLHEFNTAIEYHNRHLAIAQELGDRI 335
                    :||:..|.:|.||.:.:.||::..:|||.:....|:..|..|:.::|.:|.:|.|..
Mouse   561 LGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDME 625

  Fly   336 GEARACWSLGNAHSAIGGHERALKYAEQHLQLAKELHDPVGESTARVNIS-DLRKLLGMPDSEPS 399
            ||.:.|.:||.||..:|.::.|:||.||.|.|||:|||.:.::.|..|:. ..:.||....:|..
Mouse   626 GEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFAKAEEC 690

  Fly   400 PTEEEARSTASDHS-----ASGNQSDGSENSQGRMVRVRRQSMEQLDLIKITPDGK-RMQEEKLR 458
            .....:.:.:.|:|     |.||..|                   :.:.|...:|. :..|::| 
Mouse   691 QKYLLSLAQSLDNSQAKFRALGNLGD-------------------IFICKKDINGAIKFYEQQL- 735

  Fly   459 AQATRKAKDDDFFEMLSRSQSKRMDDQRCSIKVNPAGAPAVATGATRKPLV-----------QQN 512
                              ..|..:.|:|..       |.|.|...|...:|           |:.
Mouse   736 ------------------GLSHHVKDRRLE-------ASAYAALGTAYRMVQKYDKALGYHTQEL 775

  Fly   513 SLFVDPTNLPGLKSPSSANPSAIGHGPLARSATTTQQPDDDFLDMLMRCQGSRLEEQRSELPRPN 577
            .::.:.::|||         ....||.||.......:     ..|..:|...:||..| :|..|:
Mouse   776 EVYQELSDLPG---------ECRAHGHLAAVYMALGK-----YTMAFKCYQEQLELGR-KLKEPS 825

  Fly   578 VTMDAEAEAPPRSVPEAAVPGAPRGQTGRGATVPDEDFFSLIMKVQSGRMEDQRASIPFRNANNN 642
            :              ||.|.|      ..|.|..:.:    :|:...|..|.|.|.:...:.|.:
Mouse   826 L--------------EAQVYG------NMGITKMNMN----VMEDAIGYFEQQLAMLQQLSGNES 866

  Fly   643 NNSRSNNNGSAG 654
            ...|....|:.|
Mouse   867 VLDRGRAYGNLG 878

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pinsNP_524999.2 TPR_12 78..153 CDD:290160 30/74 (41%)
TPR 83..114 CDD:197478 13/30 (43%)
TPR repeat 83..109 CDD:276809 10/25 (40%)
TPR repeat 120..150 CDD:276809 13/29 (45%)
TPR_12 121..203 CDD:290160 29/104 (28%)
TPR_12 162..250 CDD:290160 32/110 (29%)
TPR repeat 162..199 CDD:276809 13/59 (22%)
TPR 219..251 CDD:197478 12/31 (39%)
TPR repeat 219..246 CDD:276809 9/26 (35%)
TPR repeat 251..291 CDD:276809 15/79 (19%)
TPR_12 259..330 CDD:290160 24/110 (22%)
TPR repeat 296..326 CDD:276809 8/29 (28%)
TPR_12 298..370 CDD:290160 27/71 (38%)
TPR 298..330 CDD:197478 9/31 (29%)
TPR repeat 338..366 CDD:276809 11/27 (41%)
GoLoco 468..488 CDD:280368 3/19 (16%)
GoLoco 552..573 CDD:280368 5/20 (25%)
GoLoco 613..633 CDD:280368 4/19 (21%)
Ttc28NP_001254551.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..36
TPR 1 52..85
TPR_11 57..117 CDD:290150
TPR repeat 85..115 CDD:276809
TPR 2 87..119
TPR_11 88..151 CDD:290150
TPR 3 120..153
TPR repeat 120..148 CDD:276809
TPR repeat 154..182 CDD:276809
TPR 4 190..223
TPR 5 228..261 6/21 (29%)
TPR repeat 230..256 CDD:276809 4/16 (25%)
TPR 6 268..301 8/32 (25%)
TPR repeat 268..300 CDD:276809 8/31 (26%)
TPR_11 269..339 CDD:290150 20/69 (29%)
TPR 7 308..341 14/32 (44%)
TPR_12 309..380 CDD:290160 29/70 (41%)
TPR repeat 310..336 CDD:276809 10/25 (40%)
TPR 8 348..381 13/32 (41%)
TPR repeat 348..376 CDD:276809 11/27 (41%)
TPR_7 351..385 CDD:289919 14/33 (42%)
TPR 373..687 CDD:223533 92/313 (29%)
TPR repeat 387..417 CDD:276809 8/29 (28%)
TPR 9 388..421 7/32 (22%)
TPR 388..420 CDD:197478 7/31 (23%)
TPR 10 428..461 6/32 (19%)
TPR repeat 428..455 CDD:276809 5/26 (19%)
TPR 11 468..501 13/32 (41%)
TPR repeat 469..496 CDD:276809 9/26 (35%)
TPR 12 508..541 8/32 (25%)
TPR repeat 509..536 CDD:276809 8/26 (31%)
TPR_7 510..545 CDD:289919 7/34 (21%)
TPR 13 548..581 4/32 (13%)
TPR repeat 548..576 CDD:276809 2/27 (7%)
TPR 14 588..621 9/32 (28%)
TPR repeat 588..616 CDD:276809 7/27 (26%)
TPR_7 590..625 CDD:289919 10/34 (29%)
TPR repeat 627..657 CDD:276809 13/29 (45%)
TPR 15 628..661 15/32 (47%)
TPR_7 630..664 CDD:289919 17/33 (52%)
TPR 16 668..701 5/32 (16%)
TPR 688..989 CDD:223533 49/275 (18%)
TPR repeat 706..735 CDD:276809 7/47 (15%)
TPR 17 708..741 9/70 (13%)
TPR 18 748..781 6/32 (19%)
TPR repeat 748..776 CDD:276809 6/27 (22%)
TPR 19 788..821 9/38 (24%)
TPR 788..817 CDD:197478 7/33 (21%)
TPR repeat 788..816 CDD:276809 6/32 (19%)
TPR repeat 827..857 CDD:276809 10/39 (26%)
TPR 20 828..861 10/42 (24%)
TPR 21 871..904 2/8 (25%)
TPR repeat 872..899 CDD:276809 2/7 (29%)
TPR_7 873..905 CDD:289919 2/6 (33%)
TPR repeat 910..944 CDD:276809
TPR 22 911..944
TPR 23 951..984
TPR repeat 951..978 CDD:276809
TPR_7 953..988 CDD:289919
TPR 24 991..1024
TPR repeat 991..1019 CDD:276809
TPR_12 993..1061 CDD:290160
TPR 25 1031..1064
TPR repeat 1031..1059 CDD:276809
TPR_12 1032..1103 CDD:290160
TPR repeat 1069..1099 CDD:276809
TPR 26 1071..1104
TPR_12 1073..1142 CDD:290160
TPR 27 1111..1144
TPR repeat 1111..1137 CDD:276809
TPR 28 1163..1196
TPR repeat 1163..1188 CDD:276809
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1362..1381
CHAT 1384..1707 CDD:289536
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2001..2364
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D321819at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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