DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pins and ags-3

DIOPT Version :9

Sequence 1:	NP_524999.2	Gene:	pins / 53569	FlyBaseID:	FBgn0040080	Length:	658	Species:	Drosophila melanogaster
Sequence 2:	NP_741787.1	Gene:	ags-3 / 180801	WormBaseID:	WBGene00000092	Length:	579	Species:	Caenorhabditis elegans

Alignment Length:	638	Identity:	197/638 - (30%)
Similarity:	306/638 - (47%)	Gaps:	116/638 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 CLELALEGERLCKAGDCRAGVAFFQAAIQAGTEDLRTLSAIYSQLGNAYFYLGDYNKAMQYHKHD 107
            |.:|..|||||.:......|:...:.|::.||:|...|||||.|||||:..|.||.:|:::|.:|
Worm     6 CYKLTQEGERLFRMQKYEKGIDLLKKALEVGTDDFSLLSAIYCQLGNAHTMLKDYEQALKFHTYD 70

  Fly   108 LTLAKSMNDRLGEAKSSGNLGNTLKVMGRFDEAAICCERHLTLARQLGDRLSEGRALYNLGNVYH 172
            :.:.:.:.::.|||||..||||..|:.|.:::|.....:.|..|.:||||:.:.||.||:..:|.
Worm    71 ILVERLLGNKEGEAKSCANLGNIFKMKGAYNDALTFTFKQLDFAEELGDRVLKSRAYYNIATIYV 135

  Fly   173 AKGK-----HLGQRNPGKFGDDVKEALTRAVEFYQENLKLMRDLGDRGAQGRACGNLGNTYYLLG 232
            .:|:     ...::|..|..:...: ...|.:::..||::.....|....||..|:||||||.||
Worm   136 ERGRCTKLEAAEEKNDAKNAEATSD-FENAAKYFMLNLEMSEKSEDALTMGRCYGSLGNTYYCLG 199

  Fly   233 DFQAAIEHHQERLRIAREFGDRAAERRANSNLGNSHIFLGQFEDAAEHYKRTLALAVELGEREVE 297
            |:..:|..|:.||.:::::||||:.|||::|:.|.|........|.:|||....||:|:|.:..|
Worm   200 DYDQSIHFHKLRLELSQQYGDRASMRRAHANIANCHALKSNMPLAIQHYKLAYNLAIEIGNKTEE 264

  Fly   298 AQSCYSLGNTYTLLHEFNTAIEYHNRHLAIAQELGDRIGEARACWSLGNAHSAIGGHERALKYAE 362
            ||..|||.|...:..|...||.|..|||.||:.|.|..|:.|:.:||..:.:.:....:||.:
Worm   265 AQMAYSLANALYIGKEVQKAITYFQRHLKIARSLEDISGQLRSYYSLALSFNNLCERRKALYF-- 327

  Fly   363 QHLQLAKELHDPVGESTARVNISD-LRKLL--GMPD-------------SEPSPTEEEARSTASD 411
              |.|||.....|.:::|..:|.: |.::|  |..|             ::|:|.:.|.|.....
Worm   328 --LVLAKRSSLQVNDTSALTDIDNLLNEILEAGQEDVLVDDIELIIDESADPAPADIEHRELRLT 390

  Fly   412 HSASGNQSDGSENSQGRMVRVRRQSMEQLDLIKITPDGKRMQEEKLRAQATRKAKDDDFFEMLSR 476
            :....|..|...|                     ||      |:.|   |..:.:.::||:||::
Worm   391 YFQKRNIHDKPVN---------------------TP------EDPL---AEDRYEKEEFFDMLAK 425

  Fly   477 SQSKRMDDQRCSIKV--------------NPAGAPA--------VATGATRKPLVQQNSLFVDPT 519
            .|||||:|||....|              .|..:..        :...|..:.:..|.:.|
Worm   426 LQSKRMNDQRVDASVLSSNLDFRVRQVDTEPDNSSTDGSEVLIDLLLNAQGRRMDDQRAPF---- 486

  Fly   520 NLPGLKSPSSANPSAIGHGPLARSATT--TQQPDDDFLDMLMRCQGSRLEEQRSELPRPNVTMDA 582
             ||||      ||:  |...|.|..|.  .::.|:..::.|||.||.||:|||||||
Worm   487 -LPGL------NPN--GQIILRRLNTDPGNEELDEHLVEWLMRVQGERLDEQRSELP-------- 534

  Fly   583 EAEAPPRSVPEAAVPGAPRGQTGRGATVPDEDFFSLIMKVQSGRMEDQRASIP 635
                          |..|.||. ......:||..:::|::|:||:|||||.:|
Worm   535 --------------PIKPEGQE-EVDKKKEEDVTAIVMRMQAGRLEDQRAHLP 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pins	NP_524999.2	TPR_12	78..153	CDD:290160	30/74 (41%)
		TPR	83..114	CDD:197478	13/30 (43%)
		TPR repeat	83..109	CDD:276809	13/25 (52%)
		TPR repeat	120..150	CDD:276809	12/29 (41%)
		TPR_12	121..203	CDD:290160	25/86 (29%)
		TPR_12	162..250	CDD:290160	28/92 (30%)
		TPR repeat	162..199	CDD:276809	9/41 (22%)
		TPR	219..251	CDD:197478	15/31 (48%)
		TPR repeat	219..246	CDD:276809	14/26 (54%)
		TPR repeat	251..291	CDD:276809	16/39 (41%)
		TPR_12	259..330	CDD:290160	29/70 (41%)
		TPR repeat	296..326	CDD:276809	13/29 (45%)
		TPR_12	298..370	CDD:290160	26/71 (37%)
		TPR	298..330	CDD:197478	15/31 (48%)
		TPR repeat	338..366	CDD:276809	5/27 (19%)
		GoLoco	468..488	CDD:280368	12/19 (63%)
		GoLoco	552..573	CDD:280368	11/20 (55%)
		GoLoco	613..633	CDD:280368	10/19 (53%)
ags-3	NP_741787.1	TPR_11	7..65	CDD:290150	25/57 (44%)
		TPR repeat	9..34	CDD:276809	8/24 (33%)
		TPR repeat	39..79	CDD:276809	17/39 (44%)
		TPR repeat	149..173	CDD:276809	4/24 (17%)
		TPR_12	182..255	CDD:290160	30/72 (42%)
		TPR repeat	186..213	CDD:276809	14/26 (54%)
		TPR repeat	218..254	CDD:276809	14/35 (40%)
		TPR_12	226..297	CDD:290160	29/70 (41%)
		TPR repeat	265..293	CDD:276809	12/27 (44%)
		GoLoco	417..437	CDD:280368	12/19 (63%)
		GoLoco	464..486	CDD:214645	2/21 (10%)
		GoLoco	511..533	CDD:214645	12/21 (57%)
		GoLoco	549..571	CDD:214645	11/21 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56584
Inparanoid	1	1.050	270	1.000	Inparanoid score	I1824
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45855
OrthoDB	1	1.010	-	-		D321819at33208
OrthoFinder	1	1.000	-	-		FOG0003000
OrthoInspector	1	1.000	-	-		oto20493
orthoMCL	1	0.900	-	-		OOG6_104563
Panther	1	1.100	-	-	LDO	PTHR45954
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1993
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.980