Protein Alignment pins and ags-3

DIOPT Version :10

• Sequence 1: NP_524999.2
• Gene: pins / 53569
• FlyBaseID: FBgn0040080
• Length: 658
• Species: Drosophila melanogaster
• Sequence 2: NP_741787.1
• Gene: ags-3 / 180801
• WormBaseID: WBGene00000092
• Length: 579
• Species: Caenorhabditis elegans
• Alignment Length: 638
• Identity: 197/638 - (30%)
• Similarity: 306/638 - (47%)
• Gaps: 116/638 - (18%)

  Fly    43 CLELALEGERLCKAGDCRAGVAFFQAAIQAGTEDLRTLSAIYSQLGNAYFYLGDYNKAMQYHKHD 107
            |.:|..|||||.:......|:...:.|::.||:|...|||||.|||||:..|.||.:|:::|.:|
 Worm     6 CYKLTQEGERLFRMQKYEKGIDLLKKALEVGTDDFSLLSAIYCQLGNAHTMLKDYEQALKFHTYD 70

  Fly   108 LTLAKSMNDRLGEAKSSGNLGNTLKVMGRFDEAAICCERHLTLARQLGDRLSEGRALYNLGNVYH 172
            :.:.:.:.::.|||||..||||..|:.|.:::|.....:.|..|.:||||:.:.||.||:..:|.
 Worm    71 ILVERLLGNKEGEAKSCANLGNIFKMKGAYNDALTFTFKQLDFAEELGDRVLKSRAYYNIATIYV 135

  Fly   173 AKGK-----HLGQRNPGKFGDDVKEALTRAVEFYQENLKLMRDLGDRGAQGRACGNLGNTYYLLG 232
            .:|:     ...::|..|..:...: ...|.:::..||::.....|....||..|:||||||.||
 Worm   136 ERGRCTKLEAAEEKNDAKNAEATSD-FENAAKYFMLNLEMSEKSEDALTMGRCYGSLGNTYYCLG 199

  Fly   233 DFQAAIEHHQERLRIAREFGDRAAERRANSNLGNSHIFLGQFEDAAEHYKRTLALAVELGEREVE 297
            |:..:|..|:.||.:::::||||:.|||::|:.|.|........|.:|||....||:|:|.:..|
 Worm   200 DYDQSIHFHKLRLELSQQYGDRASMRRAHANIANCHALKSNMPLAIQHYKLAYNLAIEIGNKTEE 264

  Fly   298 AQSCYSLGNTYTLLHEFNTAIEYHNRHLAIAQELGDRIGEARACWSLGNAHSAIGGHERALKYAE 362
            ||..|||.|...:..|...||.|..|||.||:.|.|..|:.|:.:||..:.:.:....:||.:
 Worm   265 AQMAYSLANALYIGKEVQKAITYFQRHLKIARSLEDISGQLRSYYSLALSFNNLCERRKALYF-- 327

  Fly   363 QHLQLAKELHDPVGESTARVNISD-LRKLL--GMPD-------------SEPSPTEEEARSTASD 411
              |.|||.....|.:::|..:|.: |.::|  |..|             ::|:|.:.|.|.....
 Worm   328 --LVLAKRSSLQVNDTSALTDIDNLLNEILEAGQEDVLVDDIELIIDESADPAPADIEHRELRLT 390

  Fly   412 HSASGNQSDGSENSQGRMVRVRRQSMEQLDLIKITPDGKRMQEEKLRAQATRKAKDDDFFEMLSR 476
            :....|..|...|                     ||      |:.|   |..:.:.::||:||::
 Worm   391 YFQKRNIHDKPVN---------------------TP------EDPL---AEDRYEKEEFFDMLAK 425

  Fly   477 SQSKRMDDQRCSIKV--------------NPAGAPA--------VATGATRKPLVQQNSLFVDPT 519
            .|||||:|||....|              .|..:..        :...|..:.:..|.:.|
 Worm   426 LQSKRMNDQRVDASVLSSNLDFRVRQVDTEPDNSSTDGSEVLIDLLLNAQGRRMDDQRAPF---- 486

  Fly   520 NLPGLKSPSSANPSAIGHGPLARSATT--TQQPDDDFLDMLMRCQGSRLEEQRSELPRPNVTMDA 582
             ||||      ||:  |...|.|..|.  .::.|:..::.|||.||.||:|||||||
 Worm   487 -LPGL------NPN--GQIILRRLNTDPGNEELDEHLVEWLMRVQGERLDEQRSELP-------- 534

  Fly   583 EAEAPPRSVPEAAVPGAPRGQTGRGATVPDEDFFSLIMKVQSGRMEDQRASIP 635
                          |..|.||. ......:||..:::|::|:||:|||||.:|
 Worm   535 --------------PIKPEGQE-EVDKKKEEDVTAIVMRMQAGRLEDQRAHLP 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pins	NP_524999.2	TPR	50..261	CDD:440225	77/215 (36%)
		TPR repeat	83..109	CDD:276809	13/25 (52%)
		TPR repeat	120..150	CDD:276809	12/29 (41%)
		TPR	162..>373	CDD:440225	74/215 (34%)
		TPR repeat	162..199	CDD:276809	9/41 (22%)
		TPR repeat	219..246	CDD:276809	14/26 (54%)
		TPR repeat	251..291	CDD:276809	16/39 (41%)
		TPR repeat	296..326	CDD:276809	13/29 (45%)
		TPR repeat	338..366	CDD:276809	5/27 (19%)
		GoLoco	468..488	CDD:460481	12/19 (63%)
		GoLoco	552..573	CDD:460481	11/20 (55%)
		GoLoco	613..633	CDD:460481	10/19 (53%)
ags-3	NP_741787.1	TPR repeat	9..34	CDD:276809	8/24 (33%)
		LapB	11..301	CDD:442196	107/290 (37%)
		TPR repeat	39..79	CDD:276809	17/39 (44%)
		TPR repeat	149..173	CDD:276809	4/24 (17%)
		TPR repeat	186..213	CDD:276809	14/26 (54%)
		TPR repeat	218..254	CDD:276809	14/35 (40%)
		TPR repeat	265..293	CDD:276809	12/27 (44%)
		GoLoco	417..436	CDD:460481	11/18 (61%)
		GoLoco	464..486	CDD:214645	2/21 (10%)
		GoLoco	511..533	CDD:214645	12/21 (57%)
		GoLoco	549..571	CDD:214645	11/21 (52%)