DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pins and PCP2

DIOPT Version :9

Sequence 1:	NP_524999.2	Gene:	pins / 53569	FlyBaseID:	FBgn0040080	Length:	658	Species:	Drosophila melanogaster
Sequence 2:	XP_016881738.1	Gene:	PCP2 / 126006	HGNCID:	30209	Length:	252	Species:	Homo sapiens

Alignment Length:	212	Identity:	54/212 - (25%)
Similarity:	74/212 - (34%)	Gaps:	78/212 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   388 RKLLGMPDSEPSPTEEEAR-----STASDHSASGNQSDGSENSQGRMVRVRRQSME----QLDLI 443
            ||:.|:...:.|..|:..|     .....||:..|        .||....|..|:|    ::.|:
Human    47 RKVTGVQGHDGSGGEDGGRLRPLCRAPRPHSSGPN--------LGRRDTHRSLSLEAVPREVALL 103

  Fly   444 KITPD-----GKR----MQEEKLRAQATRKAKDDD---FFEMLSRSQSKRMDDQRCSIKVNPAGA 496
            ...|.     ||.    .:....|..|...|...|   ||.:||..|..||:.||||::..|
Human   104 ARAPGAGAGIGKETHVSFRTALQRGSAGTMAGSPDQEGFFNLLSHVQGDRMEGQRCSLQAGP--- 165

  Fly   497 PAVATGATRKPLVQQNSLFVDPTNLPGLKSPSSANPSAIGHGPLARSATTTQQPD-DDFLDMLMR 560
                 |.|.|   .|:    |||                              |: |..:|||..
Human   166 -----GQTTK---SQS----DPT------------------------------PEMDSLMDMLAS 188

  Fly   561 CQGSRLEEQR---SELP 574
            .||.|:::||   |.||
Human   189 TQGRRMDDQRVTVSSLP 205

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pins	NP_524999.2	TPR_12	78..153	CDD:290160
		TPR	83..114	CDD:197478
		TPR repeat	83..109	CDD:276809
		TPR repeat	120..150	CDD:276809
		TPR_12	121..203	CDD:290160
		TPR_12	162..250	CDD:290160
		TPR repeat	162..199	CDD:276809
		TPR	219..251	CDD:197478
		TPR repeat	219..246	CDD:276809
		TPR repeat	251..291	CDD:276809
		TPR_12	259..330	CDD:290160
		TPR repeat	296..326	CDD:276809
		TPR_12	298..370	CDD:290160
		TPR	298..330	CDD:197478
		TPR repeat	338..366	CDD:276809
		GoLoco	468..488	CDD:280368	10/22 (45%)
		GoLoco	552..573	CDD:280368	10/23 (43%)
		GoLoco	613..633	CDD:280368
PCP2	XP_016881738.1	GoLoco	140..161	CDD:308026	10/20 (50%)
PCP2	XP_016881738.1	GoLoco	179..201	CDD:214645	9/21 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1130
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900