Protein Alignment pins and PCP2

DIOPT Version :10

• Sequence 1: NP_524999.2
• Gene: pins / 53569
• FlyBaseID: FBgn0040080
• Length: 658
• Species: Drosophila melanogaster
• Sequence 2: XP_024307114.1
• Gene: PCP2 / 126006
• HGNCID: 30209
• Length: 252
• Species: Homo sapiens
• Alignment Length: 212
• Identity: 54/212 - (25%)
• Similarity: 74/212 - (34%)
• Gaps: 78/212 - (36%)

  Fly   388 RKLLGMPDSEPSPTEEEAR-----STASDHSASGNQSDGSENSQGRMVRVRRQSME----QLDLI 443
            ||:.|:...:.|..|:..|     .....||:..|        .||....|..|:|    ::.|:
Human    47 RKVTGVQGHDGSGGEDGGRLRPLCRAPRPHSSGPN--------LGRRDTHRSLSLEAVPREVALL 103

  Fly   444 KITPD-----GKR----MQEEKLRAQATRKAKDDD---FFEMLSRSQSKRMDDQRCSIKVNPAGA 496
            ...|.     ||.    .:....|..|...|...|   ||.:||..|..||:.||||::..|
Human   104 ARAPGAGAGIGKETHVSFRTALQRGSAGTMAGSPDQEGFFNLLSHVQGDRMEGQRCSLQAGP--- 165

  Fly   497 PAVATGATRKPLVQQNSLFVDPTNLPGLKSPSSANPSAIGHGPLARSATTTQQPD-DDFLDMLMR 560
                 |.|.|   .|:    |||                              |: |..:|||..
Human   166 -----GQTTK---SQS----DPT------------------------------PEMDSLMDMLAS 188

  Fly   561 CQGSRLEEQR---SELP 574
            .||.|:::||   |.||
Human   189 TQGRRMDDQRVTVSSLP 205

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pins	NP_524999.2	TPR	50..261	CDD:440225
		TPR repeat	83..109	CDD:276809
		TPR repeat	120..150	CDD:276809
		TPR	162..>373	CDD:440225
		TPR repeat	162..199	CDD:276809
		TPR repeat	219..246	CDD:276809
		TPR repeat	251..291	CDD:276809
		TPR repeat	296..326	CDD:276809
		TPR repeat	338..366	CDD:276809
		GoLoco	468..488	CDD:460481	10/22 (45%)
		GoLoco	552..573	CDD:460481	10/23 (43%)
		GoLoco	613..633	CDD:460481
PCP2	XP_024307114.1	GoLoco	140..161	CDD:460481	10/20 (50%)
		GoLoco	179..201	CDD:214645	9/21 (43%)