DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pins and gpsm1

DIOPT Version :9

Sequence 1:	NP_524999.2	Gene:	pins / 53569	FlyBaseID:	FBgn0040080	Length:	658	Species:	Drosophila melanogaster
Sequence 2:	XP_031762710.1	Gene:	gpsm1 / 100125000	XenbaseID:	XB-GENE-1011970	Length:	660	Species:	Xenopus tropicalis

Alignment Length:	689	Identity:	313/689 - (45%)
Similarity:	419/689 - (60%)	Gaps:	134/689 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 CLELALEGERLCKAGDCRAGVAFFQAAIQAGTEDLRTLSAIYSQLGNAYFYLGDYNKAMQYHKHD 107
            ||||||||||||||||.:||..||:||:|.|||||:||||||||||||||||.:::||::|||||
Frog    25 CLELALEGERLCKAGDFKAGAVFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLKEFSKALEYHKHD 89

  Fly   108 LTLAKSMNDRLGEAKSSGNLGNTLKVMGRFDEAAICCERHLTLARQLGDRLSEGRALYNLGNVYH 172
            ||||:|:.|.:||||:||||.||||::|::|||..||:|||.::.:.|||:.|.|||||.|||:|
Frog    90 LTLARSIGDHIGEAKASGNLCNTLKILGQYDEAIACCQRHLDISLEQGDRVGEARALYNAGNVFH 154

  Fly   173 AKGKHLG---QRNPGKFGDDVKEALTRAVEFYQENLKLMRDLGDRGAQGRACGNLGNTYYLLGDF 234
            |:||.|.   .:.||...::|||.|.:|.|:||.||.|:::||||.|||||.||||||:||||:|
Frog   155 ARGKQLSWNMPQIPGDLSEEVKETLEKATEYYQRNLALVKELGDRAAQGRAYGNLGNTHYLLGNF 219

  Fly   235 QAAIEHHQERLRIAREFGDRAAERRANSNLGNSHIFLGQFEDAAEHYKRTLALAVELGEREVEAQ 299
            ..||..|:|||.||:||||:||||||.|||||:|||||:|:.:||:||:||.|:.:|.::.||||
Frog   220 SEAIAFHKERLAIAKEFGDKAAERRAYSNLGNAHIFLGKFDVSAEYYKKTLQLSRQLKDQAVEAQ 284

  Fly   300 SCYSLGNTYTLLHEFNTAIEYHNRHLAIAQELGDRIGEARACWSLGNAHSAIGGHERALKYAEQH 364
            :|||||||||||.::..||::|.:||.||||||||:||.||.||||||:.:.|.|.:||..|.:|
Frog   285 ACYSLGNTYTLLRDYERAIDFHLKHLCIAQELGDRVGEGRAAWSLGNAYVSSGDHGKALGCARKH 349

  Fly   365 LQLAKELHDPVGESTARVNISDLRKLLGMPDSEPSPTEEEARSTASDHSASGNQSDGSENSQGRM 429
            |::::|:.|..||.|||:||..||..||:.|.:.||                 |.||.|....|.
Frog   350 LEISQEIGDKNGELTARMNIMQLRSALGIQDGDSSP-----------------QYDGYEAQGARP 397

  Fly   430 VRVRRQSMEQLDLIK----------------ITPD--GKRMQEEKLR------------------ 458
            .||:|.||:.|:||.                :.||  .|..:.:|.|
Frog   398 KRVQRHSMDSLELIPFPSDKEQNGDGPHPLGLKPDSVAKPCRSKKYRNHHFCPEANAQEVPTLDS 462

  Fly   459 ---------AQATRKAKDDD-FFEMLSRSQSKRMDDQRCSIKVNPAGAPAVATGATRKPL----V 509
                     .:..|...|:: ||::||:.||.|||||||.::.:..|....:  ||..|.    :
Frog   463 NDVRVQMPPLKINRAPSDEECFFDLLSKFQSNRMDDQRCPLEESQTGMSEAS--ATPVPAPEDRI 525

  Fly   510 QQNSLFVDPT------------------------NLPGLKSPSSANPSAIGHGPLARSATTTQQP 550
            ..:||...|.                        |||||:    ...:.:||   .|.....|:|
Frog   526 SASSLMASPQTEEFFDLIASSQSRRLDDQRASVGNLPGLR----LTHNNMGH---LRVEGDQQEP 583

  Fly   551 DDDFLDMLMRCQGSRLEEQRSELPRPNVTMDAEAEAPPRSVPEAAVPGAPRGQTGRGATVPDEDF 615
            .|:|.:|||:||.||:::||.              |||.::|             ||.|:|||||
Frog   584 GDEFFNMLMKCQSSRIDDQRC--------------APPDTIP-------------RGPTMPDEDF 621

  Fly   616 FSLIMKVQSGRMEDQRASIPF----RNANNNNNSRSNNN 650
            ||||.:||:.||::||..:..    .:|....:.||:|:
Frog   622 FSLIQRVQAKRMDEQRVDLSSNQEEEDARPEGDQRSSNS 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pins	NP_524999.2	TPR_12	78..153	CDD:290160	50/74 (68%)
		TPR	83..114	CDD:197478	23/30 (77%)
		TPR repeat	83..109	CDD:276809	19/25 (76%)
		TPR repeat	120..150	CDD:276809	20/29 (69%)
		TPR_12	121..203	CDD:290160	45/84 (54%)
		TPR_12	162..250	CDD:290160	54/90 (60%)
		TPR repeat	162..199	CDD:276809	20/39 (51%)
		TPR	219..251	CDD:197478	21/31 (68%)
		TPR repeat	219..246	CDD:276809	18/26 (69%)
		TPR repeat	251..291	CDD:276809	27/39 (69%)
		TPR_12	259..330	CDD:290160	43/70 (61%)
		TPR repeat	296..326	CDD:276809	19/29 (66%)
		TPR_12	298..370	CDD:290160	43/71 (61%)
		TPR	298..330	CDD:197478	20/31 (65%)
		TPR repeat	338..366	CDD:276809	14/27 (52%)
		GoLoco	468..488	CDD:280368	12/20 (60%)
		GoLoco	552..573	CDD:280368	11/20 (55%)
		GoLoco	613..633	CDD:280368	13/19 (68%)
gpsm1	XP_031762710.1	TPR repeat	28..53	CDD:276809	19/24 (79%)
		TPR repeat	65..91	CDD:276809	19/25 (76%)
		TPR	<66..316	CDD:223533	155/249 (62%)
		TPR repeat	102..132	CDD:276809	20/29 (69%)
		TPR repeat	143..191	CDD:276809	24/47 (51%)
		TPR_12	204..275	CDD:315987	49/70 (70%)
		TPR repeat	204..231	CDD:276809	18/26 (69%)
		TPR repeat	236..272	CDD:276809	26/35 (74%)
		TPR repeat	283..310	CDD:276809	16/26 (62%)
		TPR_12	287..355	CDD:315987	40/67 (60%)
		TPR repeat	323..351	CDD:276809	14/27 (52%)
		GoLoco	482..501	CDD:396661	11/18 (61%)
		GoLoco	537..556	CDD:396661	0/18 (0%)
		GoLoco	585..604	CDD:396661	10/18 (56%)
		GoLoco	619..638	CDD:396661	12/18 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	589	1.000	Inparanoid score	I979
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D321819at33208
OrthoFinder	1	1.000	-	-		FOG0003000
OrthoInspector	1	1.000	-	-		otm49436
Panther	1	1.100	-	-	LDO	PTHR45954
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1993
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.160