DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment larp and SLF1

DIOPT Version :9

Sequence 1:	NP_001247347.1	Gene:	larp / 53567	FlyBaseID:	FBgn0261618	Length:	1673	Species:	Drosophila melanogaster
Sequence 2:	NP_010803.3	Gene:	SLF1 / 852127	SGDID:	S000002923	Length:	447	Species:	Saccharomyces cerevisiae

Alignment Length:	555	Identity:	113/555 - (20%)
Similarity:	185/555 - (33%)	Gaps:	213/555 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   309 NNNAQNTASNKKTQQQQQPQQGATTTTQTTTAAAAAATAAAAATAATTSAAAATSSAAAVPAATT 373
            |:|.:||:|..:.:::|                                    |||....|..||
Yeast     7 NDNPKNTSSAAEDKKKQ------------------------------------TSSLKLAPIPTT 35

  Fly   374 ETATTTTVDASQADALAKVVVKDKKKVNQKASDFSNVGDWPTLIGGTSGSGKATSNEPKRNPTKK 438
            ....:::.|::..     :.|::.:.:::.|....|          .|||.|.||| .|..|.
Yeast    36 SPWKSSSPDSNTV-----IPVEELRDISKTAKPSKN----------GSGSIKLTSN-TKWTPI-- 82

  Fly   439 QQSAKTAAAVAASSNTTSSEVATESNVAGTTSSSNS----NPSSSTTTTNTTTNSQATTAPVAST 499
                 |.:.:.:.|..|:|:....|..:.|......    |...:....|..|||   |:.:::.
Yeast    83 -----TPSVIISGSKDTNSKSGKNSKNSKTNKKMKKRGKYNNDINKKDFNGQTNS---TSEISNV 139

  Fly   500 SHDAKAQRDAEPAANSAAGTTGTAAGPALTKKIPKHKWRPLPIDLAKSSRPKPIGGRPNRRFSDD 564
            |:......||....|..:.:..||.|.  .|:|              ::......||.:|.
Yeast   140 SNLESKPLDANAKVNIHSSSGATANGN--IKRI--------------TNNNNSTNGRQSRN---- 184

  Fly   565 IADQRRPPRVYHDRQPGAGGAGVESRHPHAGRHPYGSRPATATSERVDSWRSSSSTTTAAFDEQR 629
                      |.:|..       ::|:.:..||                  |.::....:|
Yeast   185 ----------YQNRNG-------KTRYNNNSRH------------------SQAANNAISF---- 210

  Fly   630 SGAAGGAGAAGTGVGSATRGPRRYRTPYRGGRQGRGGFSRQGPGRPTYRIPR--HLLASGEYANY 692
                                |..|:                  .||.| ||.  |.|.:....:|
Yeast   211 --------------------PNNYQ------------------ARPEY-IPNASHWLNNNSRNSY 236

  Fly   693 LPADAAGADSQSSYVLMGTHYFGNV--------PAAY-IELDANSIKEAIKKQVEYYFSVDNLTG 748
                     .|.|| .....|:.|:        |..| :|....|| |:||.|:|:|||.:||..
Yeast   237 ---------KQLSY-FRQQQYYNNINYQQQLQTPYYYSMEPIFKSI-ESIKNQIEFYFSEENLKT 290

  Fly   749 DFFLRRKMDP--EGYIPVTLIASFHRV--LALTTDVAVIVNAIKESDKLELFEGYKVRTKTTPTT 809
            |.|||.|...  :|:||::||..|:|:  |:|..|..:|:.:::|
Yeast   291 DEFLRSKFKKANDGFIPMSLIGKFYRMVNLSLGGDPNLILASMRE-------------------- 335

  Fly   810 WPITEVPEVNEGEPKAIGTLEQEQLEQNDGQEKLE 844
              :.:..|.|..| .|:|::|..|....|....||
Yeast   336 --VLQHKETNHLE-IALGSIEGAQKNMADDFNPLE 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
larp	NP_001247347.1	LARP_1_2	730..803	CDD:153403	27/76 (36%)
		DM15	1341..1382	CDD:128927
		DM15	1383..1421	CDD:128927
SLF1	NP_010803.3	LHP1	3..443	CDD:227520	113/555 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001290
OrthoInspector	1	1.000	-	-		mtm9176
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22792
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1945
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.030