DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment larp and LARP1a

DIOPT Version :9

Sequence 1:	NP_001247347.1	Gene:	larp / 53567	FlyBaseID:	FBgn0261618	Length:	1673	Species:	Drosophila melanogaster
Sequence 2:	NP_001190354.1	Gene:	LARP1a / 832242	AraportID:	AT5G21160	Length:	833	Species:	Arabidopsis thaliana

Alignment Length:	1172	Identity:	290/1172 - (24%)
Similarity:	407/1172 - (34%)	Gaps:	434/1172 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   373 TETATTTTVDASQADALAKVVVKDKKKVNQKASDFSNVGDWPTLIGGTSGSGKATSNEPKRNPTK 437
            |.|:...|:||....|                      ..||.|      :..|....||..|.
plant    30 TTTSPVETIDAPVMGA----------------------HSWPAL------ADAAQQPRPKNPPA- 65

  Fly   438 KQQSAKTAAAVAASSNTTSSEVATESNVAGTTSSSNSNPSSSTTTTNTTTNSQATTAPVASTSHD 502
                  .|.|..:.:..||..:.|.: |.|...|.....                    |:..|.
plant    66 ------PAPAPPSKNIPTSIPIPTPA-VTGQAKSKGGGK--------------------ANPGHK 103

  Fly   503 AKAQRDAEPAANSAAGTTGTAAGPALTKKIPKHKWRPLPIDLAKSSRPKPIGGRPNRRFSDDIAD 567
            ..:.|.::|...|  ...|....|.|...:|.|              |.|.
plant   104 NPSGRHSKPGPRS--NQNGPPPPPYLVHAVPYH--------------PPPF-------------- 138

  Fly   568 QRRPPRVYHDRQPGAGGAGVESRHPHAGRHPYGSRPATATSERVDSWRSSSSTTTAAFDEQRSGA 632
               ||.|     |....||.:  .|:|...|| ..|....:|..:..:..:|.........: |.
plant   139 ---PPMV-----PLPHAAGPD--FPYAPYPPY-PVPVPPVTESGNEKQVQASPLPPVLPAPQ-GD 191

  Fly   633 AG-------GAGAAGTGVGSATRGPRRY-RTPYRGGRQGRGGFSRQGPG--RPTYRIPRHLLASG 687
            .|       |........|:   |||.: |.|:.|  ...|.....|||  .|.|
plant   192 PGKPWPHQRGFDPRNMPQGA---GPRNFGRPPFMG--PAPGFLVGPGPGFPGPVY---------- 241

  Fly   688 EYANYLPADAAGADSQSSYVLMGTHYFGNVPAAYIELDANSIKEAIKKQVEYYFSVDNLTGDFFL 752
                |||....|| .:..|......|..|.....:..:...:::.:.||||||||.:||..|.:|
plant   242 ----YLPGPPPGA-IRGPYPPRFAPYPVNQGPPILSPEKLDLRDRVLKQVEYYFSDENLENDHYL 301

  Fly   753 RRKMDPEGYIPVTLIASFHRVLALTTDVAVIVNAIKESDKLELFEGYKVRTKTTPTTWPITEVPE 817
            ...||.||::|..:||.|.||.|:|.||..||.|:..|:.:|: :|.::|.:...:.|    :|
plant   302 ISLMDEEGWVPTKIIAGFKRVKAMTMDVDFIVYALGFSNSVEV-QGDQIRKRDKWSDW----IP- 360

  Fly   818 VNEGEPKAIGTLEQEQLEQNDGQEKLEEQTEADSPPPILTSAMATKPLNSIPPPPMPRNPQNLVP 882
                                                       |:|
plant   361 -------------------------------------------ASK------------------- 363

  Fly   883 KMLQDKQQSRSSTIAALNSVNAISALTQQVEGGAAELAGHLSGLAESVKPKSTSTPDKRNAASAG 947
                                                              ||||      |.:.|
plant   364 --------------------------------------------------KSTS------AETIG 372

  Fly   948 NGAGSAAALVAEPEGIWKEVKRRSKTNAIKENATTPPQQQQPPLSQTLNNNNDNVKTNNTSSKSK 1012
            :|                                    .:..|.|.|..:|..|
plant   373 DG------------------------------------DKDSPKSITSGDNFGN----------- 390

  Fly  1013 SSSNNAPSNASSSATVCVTTNNASSATKATTKTTTTSTATTTTNNNIKSGNAAYSKTHSKSSSKT 1077
                  ||..||..||    ::.||....:::|           ||.||||.       |||:.
plant   391 ------PSKGSSKPTV----SDFSSEGAQSSRT-----------NNYKSGNL-------KSSAD- 426

  Fly  1078 AAPPSAQCHAEKEELD---------FQFDEEL----MDPLPPGTGRINNFTENFSDDDESDYEFA 1129
                      ||..::         |..||||    ..|...|.....:.  .:.|||.:   ..
plant   427 ----------EKRNVEDLSNDFSNTFLLDEELDLEHRSPRKSGLSMSKSI--EYEDDDMA---VD 476

  Fly  1130 DRDINKLLIVAQVGRAPKHEGYDRTADFTSRTKITQDLENIINDGLVNYEEDLWTTTNVVADYKT 1194
            |:||.||:||.|  .:.|.:|  .....|....|.::|.:.|||||..:|::|
plant   477 DQDIQKLVIVTQ--NSGKSDG--AGIGGTEAKNIPKELASTINDGLYYFEQEL------------ 525

  Fly  1195 VNVISQADFEKLAGGRNKSVLPPQVVPPPPPFEEDLD------------ETLVGDTTLNSTLNN- 1246
                     :|...||.|:             ...||            .|.:|:   ||..|:
plant   526 ---------KKKRSGRRKN-------------NSHLDTKDGKIKSGEGLNTKLGE---NSAANDG 565

  Fly  1247 -----TLKSRRARFYAAPNSHSIDPRTPRKRKLRHTAN---PPVEAHVGWLLDTV---EHRPRTT 1300
                 .:.|||.:.......|:...|......:|:..|   .|..:.:|:...:.   .|.||.:
plant   566 GEEHGIITSRRKQNKGTHKHHTAHARRFFSSNIRNNGNISESPPSSSIGFFFGSTPPDSHGPRLS 630

  Fly  1301 SMGSS-----AGTSPTASSYGSFGSSVPQSLPVFQHPSHALLKENNFTQQAYHKYHSRCLKERRR 1360
            .:.||     :|:||..       .|:|:|.|.||||||.||:||.|.|:.|.||..|||.||::
plant   631 KLSSSPQCTLSGSSPPV-------GSLPKSFPPFQHPSHQLLEENGFKQEKYLKYRKRCLNERKK 688

  Fly  1361 LGYGQSQEMNTLYRFWSFFLRENFNKSMYNEFRSLALEDAGNGFRYGLECLFRFFSYGLEKKFRP 1425
            ||.|.|:|||.||||||:|||:.|..|||::|:..|||||...:.|||||||||:||||||.|..
plant   689 LGSGCSEEMNHLYRFWSYFLRDTFVLSMYDDFQKFALEDAAGNYDYGLECLFRFYSYGLEKHFDE 753

  Fly  1426 NIYQDFQDETIADYETGQLYGLEKFWAFLKYYKNGEKLEVQPKLAEYLK-SFKNIEDFRVVEPEI 1489
            ::|:||:..::..|..|.||||||:|||..|....|.:...|:|.:.|| .|::|:|||..|...
plant   754 DLYKDFEKLSLDFYHKGNLYGLEKYWAFHHYRGKEEPITKHPELEKLLKEEFRSIDDFRAKETIT 818

  Fly  1490 NE 1491
            |:
plant   819 NQ 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
larp	NP_001247347.1	LARP_1_2	730..803	CDD:153403	32/72 (44%)
		DM15	1341..1382	CDD:128927	25/40 (63%)
		DM15	1383..1421	CDD:128927	23/37 (62%)
LARP1a	NP_001190354.1	LAM	279..351	CDD:153396	32/72 (44%)
		DM15	670..710	CDD:128927	25/39 (64%)
		DM15	712..749	CDD:128927	23/36 (64%)
		DM15	750..785	CDD:128927	15/34 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	229	1.000	Domainoid score	I659
eggNOG	1	0.900	-	-		E1_COG5193
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	298	1.000	Inparanoid score	I791
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D258488at2759
OrthoFinder	1	1.000	-	-		FOG0001290
OrthoInspector	1	1.000	-	-		oto3551
orthoMCL	1	0.900	-	-		OOG6_103868
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2271
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.730