DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment larp and Larp1

DIOPT Version :9

Sequence 1:	NP_001247347.1	Gene:	larp / 53567	FlyBaseID:	FBgn0261618	Length:	1673	Species:	Drosophila melanogaster
Sequence 2:	NP_082727.1	Gene:	Larp1 / 73158	MGIID:	1890165	Length:	1072	Species:	Mus musculus

Alignment Length:	1487	Identity:	449/1487 - (30%)
Similarity:	591/1487 - (39%)	Gaps:	520/1487 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 ARKEKPRDQQPAGGRGDGQKPQQAGGRRV------PGSSDTERKSVRPRAPRGGSPRKSAAGAAG 192
            |||:...|.|...|.|||......|.||.      ||....||:|.||
Mouse    24 ARKKPAPDAQAESGPGDGGGEPDGGVRRPRPACARPGRDGAERESPRP----------------- 71

  Fly   193 AAGSNAGAVSSAVPGGPKVHKDRKDTSPSASIEGAGSSGNEAKSADGDQQAGEKGAAGAAPPPKR 257
                                       |:|:...|||.|.:....|
Mouse    72 ---------------------------PAAAEAPAGSDGEDGGRRD------------------- 90

  Fly   258 FIAAPPPKVNAWKISAKQSGSPKAGTSPLDKRVLQPKAQQQQQQTKQTASQNNNAQNTASNKKTQ 322
            |:.|||||||.|   .|.:..|.|                                       ..
Mouse    91 FVEAPPPKVNPW---TKHAPPPAA---------------------------------------VN 113

  Fly   323 QQQQPQQGATTTTQTTTAAAAAATAAAAATAATTSAAAATSSAAAVPAATTETATTTTVDASQAD 387
            .|..|:                           .||.|....|||
Mouse   114 GQPPPE---------------------------PSAPAKVVRAAA-------------------- 131

  Fly   388 ALAKVVVKDKKKVNQKASDFSNVGDWPT--LIGGTSGSGKATSNEPKRN-PTKKQQSAKTAAAVA 449
                    .|.:...|..||.:..:|||  .|...|...::...:|.|. |.||..
Mouse   132 --------PKPRKGSKVGDFGDAVNWPTPGEIAHKSVQPQSHKPQPARKLPPKKDM--------- 179

  Fly   450 ASSNTTSSEVATESNVAGTTSSSNSNPSSSTTTTNTTTNSQATTAPVASTSHDAKAQRDAEPAAN 514
                        :....|..|.|..:|.:.:..:....|.            |...||..:
Mouse   180 ------------KEQEKGDGSDSKESPKTKSDESGEEKNG------------DEDCQRGGQ---- 216

  Fly   515 SAAGTTGTAAGPALTKKIPKHKWRPLPIDLAKSSRPKPIGGRPNRRFSDDIADQRRPPRVYHDRQ 579
                          .||..||||.||.||:......:.:..||.|            |:
Mouse   217 --------------KKKGSKHKWVPLQIDMKPEVPREKLASRPTR------------PQ------ 249

  Fly   580 PGAGGAGVESRHPHAGR-HPYGSRPAT----ATSERVDSWRSSSSTTTAAFDEQRSGAAGGAGAA 639
                    |.||..|.| ...||.|||    :.:....:|:..:....|..|:..:.:....||.
Mouse   250 --------EPRHTPAVRGEMKGSEPATYMPVSVAPPTPAWQPETKVEPAWHDQDETSSVKSDGAG 306

  Fly   640 GTGVGSATRGPRRYRTPYRGGRQGRGGFSRQGPGRPTYRIPRHLLASGEYA-NYLPADAAGADSQ 703
            |.            |..:||..:|||    :|.||.......|.    :|. .|...|.......
Mouse   307 GA------------RASFRGRGRGRG----RGRGRGRGGTRTHF----DYQFGYRKFDGTEGPRT 351

  Fly   704 SSYVLMGTHYFGNVPAAYI-ELDANSIKEAIKKQVEYYFSVDNLTGDFFLRRKMDPEGYIPVTLI 767
            ..|:...|:||.||.:..| .:|...:|:.||:|:|||||||||..|||||||||.:|::|:|||
Mouse   352 HKYMNNITYYFDNVSSNEIYSMDQELLKDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLI 416

  Fly   768 ASFHRVLALTTDVAVIVNAIKESDKLELFEGYKVRTKTTPTTWPITEVPEVNEGEPKAIGTLEQE 832
            ||||||.|||||:::|..|:|:|..:|:.| .|||.:..|..||:...|.|:
Mouse   417 ASFHRVQALTTDISLIFAALKDSKVVEMVE-EKVRRREEPEKWPLPGPPIVD------------- 467

  Fly   833 QLEQNDGQEKLEEQTEADSPPPILTSAMATKPLNSIPPPPMPRNPQNLVPKMLQDKQQSRSSTIA 897
             ..|.|..:.|                                |....||     :|..:..|.:
Mouse   468 -YSQTDFSQLL--------------------------------NCPEFVP-----RQHYQKETES 494

  Fly   898 ALNSVNAISALTQQVEGGAAELAGHLSGLAESVKPKSTSTPDKRNAASAGNGAGSAAALVAEPEG 962
            |..|..|::.:..:.|        .:|.|....|..|.|.||..:.:
Mouse   495 APGSPRAVTPVPTKTE--------EVSNLKTLPKGLSASLPDLDSES------------------ 533

  Fly   963 IWKEVKRRSKTNAIKENATTPPQQQQPPLSQTLNNNNDNVKTNNTSSKSKSSSNNAPSNASSSAT 1027
             |.|||:|.:.:..:     |.:.::|
Mouse   534 -WIEVKKRPRPSPAR-----PKKPEEP-------------------------------------- 554

  Fly  1028 VCVTTNNASSATKATTKTTTTSTATTTTNNNIKSGNAAYSKTHSKSSSKTAAP---PSAQCHA-- 1087
                                                        :.|..||.|   ||.|..:
Mouse   555 --------------------------------------------RFSHPTALPQQLPSQQLMSKD 575

  Fly  1088 --EKEELDFQFDEEL--MDPLPPGTGRINNFTENFSDDDESDYEFADRDINKLLIVAQVGRAP-- 1146
              |:|||||.||||:  ||      ||.|.||. :|::| ||||..|||:||:|||.|.  .|
Mouse   576 QDEQEELDFLFDEEMEQMD------GRKNTFTA-WSEED-SDYEIDDRDVNKILIVTQT--PPYM 630

  Fly  1147 -KHEGYDRTADFTSRTKITQDLENIINDGLVNYEEDLWT---------TTNVVADYKTVNVISQA 1201
             :|.|.|||.:.|||.|::.:|..:|||||..||:||||         ....|.::|.||:||:.
Mouse   631 RRHPGGDRTGNHTSRAKMSAELAKVINDGLFYYEQDLWTEKFEPEYSQIKQEVENFKKVNMISRE 695

  Fly  1202 DFEKLAGGRNKSVLPPQVVPP-PPPFEEDLDETLVG-------DTTLNSTLNNTL---------- 1248
            .|:.|.  ....|.|.|.||| ||.|::...:.|..       .:|:..:|..|:
Mouse   696 QFDTLT--PEPPVDPNQEVPPGPPRFQQVPTDALANKLFGAPEPSTIARSLPTTVPESPNYRNAR 758

  Fly  1249 ------------KSRRARFY-AAPNSHSIDPRTPRKRKLRHTANPPVEAHVGWLLDTVEHRPRTT 1300
                        .|:..||| ......::|.:.|||||.||::|||:|:||||::|:.||||||.
Mouse   759 TPRTPRTPQLKDSSQTPRFYPVVKEGRTLDAKMPRKRKTRHSSNPPLESHVGWVMDSREHRPRTA 823

  Fly  1301 SMGS--SAGTSPTASSYGSFGSSVPQSLPVFQHPSHALLKENNFTQQAYHKYHSRCLKERRRLGY 1363
            |:.|  |.|| |...|||    ..|||||.||||||.|||||.|||..||||..|||.||:|||.
Mouse   824 SISSSPSEGT-PAVGSYG----CTPQSLPKFQHPSHELLKENGFTQHVYHKYRRRCLNERKRLGI 883

  Fly  1364 GQSQEMNTLYRFWSFFLRENFNKSMYNEFRSLALEDAGNGFRYGLECLFRFFSYGLEKKFRPNIY 1428
            |||||||||:||||||||::|||.||.||:.||||||..|:|||||||||::|||||||||.:|:
Mouse   884 GQSQEMNTLFRFWSFFLRDHFNKKMYEEFKQLALEDAKEGYRYGLECLFRYYSYGLEKKFRLDIF 948

  Fly  1429 QDFQDETIADYETGQLYGLEKFWAFLKYYKNGEKLEVQPKLAEYLKSFKNIEDFRVVEPEINEML 1493
            :|||:||:.|||.|||||||||||||||.| .:.|::.|||.|||..|:.:|||| |:|.:.|
Mouse   949 KDFQEETVKDYEAGQLYGLEKFWAFLKYSK-AKNLDIDPKLQEYLGKFRRLEDFR-VDPPMGE-- 1009

  Fly  1494 QGVGSLNP----GRQLNRHRSVSESDGTAVIAAGGRRLNTTITNRSDYVGRLLQQQH 1546
            :|....:|    |....|.|..|:|....  |.|..:..||.|.::.........||
Mouse  1010 EGNHKRHPVVAGGSGEGRKRCPSQSSSRP--ATGISQPPTTPTGQATREDAKWTSQH 1064

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
larp	NP_001247347.1	LARP_1_2	730..803	CDD:153403	46/72 (64%)
		DM15	1341..1382	CDD:128927	31/40 (78%)
		DM15	1383..1421	CDD:128927	27/37 (73%)
Larp1	NP_082727.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..268		90/480 (19%)
		Required for interaction with PABPC1. /evidence=ECO:0000250\|UniProtKB:Q6PKG0	70..550		179/820 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	289..331		14/57 (25%)
		LARP_1_2	379..451	CDD:153403	46/72 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	488..578		26/203 (13%)
		Required for interaction with RPTOR and for repression of mRNAs with a 5'TOP motif. /evidence=ECO:0000250\|UniProtKB:Q6PKG0	551..1072		253/619 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	737..773		3/35 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	790..837		28/47 (60%)
		Interaction with mRNA. /evidence=ECO:0000250\|UniProtKB:Q6PKG0	850..1000		107/150 (71%)
		DM15	862..902	CDD:128927	31/39 (79%)
		DM15	903..941	CDD:128927	27/37 (73%)
		Interaction with 7-methylguanosine mRNA cap structure. /evidence=ECO:0000250\|UniProtKB:Q6PKG0	933..976		32/42 (76%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1003..1072		17/66 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	89	1.000	Domainoid score	I7830
eggNOG	1	0.900	-	-		E1_COG5193
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	591	1.000	Inparanoid score	I984
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D258488at2759
OrthoFinder	1	1.000	-	-		FOG0001290
OrthoInspector	1	1.000	-	-		oto92296
orthoMCL	1	0.900	-	-		OOG6_103868
Panther	1	1.100	-	-	LDO	PTHR22792
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1945
SonicParanoid	1	1.000	-	-		X2271
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.900