DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment larp and larp4b

DIOPT Version :9

Sequence 1:	NP_001247347.1	Gene:	larp / 53567	FlyBaseID:	FBgn0261618	Length:	1673	Species:	Drosophila melanogaster
Sequence 2:	XP_021325871.1	Gene:	larp4b / 563742	ZFINID:	ZDB-GENE-061027-39	Length:	1862	Species:	Danio rerio

Alignment Length:	779	Identity:	149/779 - (19%)
Similarity:	245/779 - (31%)	Gaps:	240/779 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   689 YANYLPADAAGA----DSQSSYVLMGTHYFGNVPAAY------------------IEL------- 724
            :|||:|...|.|    |||.|:|.........:...|                  :||
Zfish  1178 WANYMPKPEASAPTCPDSQQSWVEAADDPSNCISDGYNNSEDKGNWNEEQQVSTSVELPFAAQPE 1242

  Fly   725 -------------------------DANS------IKEAIKKQVEYYFSVDNLTGDFFLRRKMDP 758
                                     |::|      ::|.:|..:|:..|.:||..|.:|..:||.
Zfish  1243 SVYLGSSVIEKGIVSNQNTSMKGVDDSDSSRQLEDLREQLKATLEFCLSRENLANDMYLISQMDS 1307

  Fly   759 EGYIPVTLIASFHRVLALTTDVAVIVNAIK-----ESDKLELFEGYKVR---------TKTTPTT 809
            :.|:|:..:|:..::..|||||.:|.:.:|     :.||.    |.|||         .:..|..
Zfish  1308 DQYVPIVTLANLDQIKKLTTDVDLISDILKTLPLVQVDKC----GEKVRPNQNRCIVILREIPEA 1368

  Fly   810 WPITEVPEV--NEGEPKAIG-----------TLEQEQLEQNDGQ---EKLEEQTEADSPPP---- 854
            .|:.||..:  ::..||.|.           |.|.|.    |.|   :.|.|:.:.....|
Zfish  1369 TPLEEVEALFKSDNLPKFINCEFAYNDNWFITFESEA----DAQLAYQYLREEVKTFQGKPIKAR 1429

  Fly   855 ILTSAMATK---PLNSIPPPPMPRNPQN-----LVPKMLQDKQQSRSSTIAALNSVNAISALTQQ 911
            |...|:|..   |.|...|..:..|.|.     .:|.:...:||.....:......:|..:....
Zfish  1430 IKAKAIAVNTFVPKNGYRPVDVSSNVQQRYTPYYIPPVYGAQQQFPLYRLVTPQGWSATQSYLDP 1494

  Fly   912 VEGGAAELAGHLSGLAESVKPKSTSTP-DKRNAASAGNGAGSAAALVAEPEGIWKEVKRRSKTNA 975
            ...........::|.|.|...||.::| ..|:...|..........:..|         ..:...
Zfish  1495 TLVSPFPSPAFINGFAGSPTFKSATSPLTVRHYTHAPRNRNHNKTHIRLP---------TDRGTT 1550

  Fly   976 IKEN----ATTP----PQQQQPPLSQTLNNNNDNVKTNNTSSKSKSSSNNAPSNASSSATVCVTT 1032
            :.||    :|.|    |...:||            :|::..|:.:..:..|........:..:..
Zfish  1551 LLENPAAFSTFPTERIPNGTRPP------------QTHHLGSRPRLPTGLAYPRRDQVGSGRMEV 1603

  Fly  1033 NNASSATKATTKTTTTSTATTTTNNNIKSGNAAYSKTHSKSS---SKTAAPPSAQCHAEKEELDF 1094
            |.|..:..|               ...:.|...|.|....:.   |.|.:||..|  .......|
Zfish  1604 NGADYSLNA---------------GRGRRGGFGYRKRRDDNKFPRSGTQSPPPVQ--ERTPSPSF 1651

  Fly  1095 QFDEELMDPLPPGTGRINNFT--ENFSDDDESDYEFA---DRDINKLLIVAQVGRAPKHEGYDRT 1154
            :.......|||...|.:....  ||..|:..||....   |:.:||.::.::|......|.....
Zfish  1652 ELGLSSFPPLPGAAGNLKPEVKPENSLDNRLSDVVIGAVKDKPLNKDVVTSRVISGTPKESVQAA 1716

  Fly  1155 ADFTSRTKITQDLENIINDGLVNYEEDLWTTTNVVADYKTVNVISQADFEKLAGGRNKSVLPPQV 1219
            ....::|.:                           |::.....:|..              |..
Zfish  1717 PAPAAQTPV---------------------------DHQHSPSPAQTS--------------PTA 1740

  Fly  1220 VPPP----PPFEEDLDETLVGDTTLNSTLNNTLKSR-RARFYA-------------------APN 1260
            |..|    .|.|:..|......|.|::.:..:|:.. |...||                   ||:
Zfish  1741 VEKPKETQTPAEKCSDTHAAKTTPLSNPVTVSLQQEPRKPSYAEICQRIREAPTQQPSADPRAPS 1805

  Fly  1261 SHSIDPRTP--RKRKLRHTANPPVEAHVGWLLDTVEHRPR-TTSMGSSAGTSPTASSYGSFGSS 1321
            |.:.|.:||  .:|:.:.:|:.|.::       |....|| |.....|.|...||.:..||..|
Zfish  1806 STAEDVKTPDSAERRCKESASAPAKS-------TATACPRETVKSQQSPGDRATAGTTASFHQS 1862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
larp	NP_001247347.1	LARP_1_2	730..803	CDD:153403	26/86 (30%)
		DM15	1341..1382	CDD:128927
		DM15	1383..1421	CDD:128927
larp4b	XP_021325871.1	LARP_5	1279..1353	CDD:153405	25/77 (32%)
		RRM_LARP5	1358..1434	CDD:241150	16/79 (20%)
		Atrophin-1	<1632..1862	CDD:331285	54/279 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586333
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840