DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment larp and SPAC1527.03

DIOPT Version :9

Sequence 1:	NP_001247347.1	Gene:	larp / 53567	FlyBaseID:	FBgn0261618	Length:	1673	Species:	Drosophila melanogaster
Sequence 2:	NP_594554.1	Gene:	SPAC1527.03 / 2541645	PomBaseID:	SPAC1527.03	Length:	475	Species:	Schizosaccharomyces pombe

Alignment Length:	548	Identity:	106/548 - (19%)
Similarity:	188/548 - (34%)	Gaps:	178/548 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   422 GSGKATSNEPKRNPTKKQQSAKTAAAVAASSNTTSSEVATESNVAGTTSSSNSN----------- 475
            |:|...|.|.::...|..|::.|......:.|..::..:::.:.:.....||.|
pombe    26 GTGAVISEEREKEVLKNLQNSLTGKTAEENLNDEANHTSSDKSKSEDYQPSNVNVWALRKEKMIP 90

  Fly   476 -------------PSSSTTTTNTTTNSQATTAPVASTSHDAKAQRDAEPAANSAAGTTGTAAGPA 527
                         .|......|...:.:.....|........:|:...|.||.
pombe    91 KKHSHVKQEKRFSKSLQLQDPNVWPSPEIAEKQVEDRKLSDDSQKPLAPKANG------------ 143

  Fly   528 LTKKIPKHKWRPL-------PIDLAKSSRPKPIGGRPNRRFSDDIADQRRPPRVYHDRQPGAGGA 585
                  |.||..:       ||...||||.:..|.|.|
pombe   144 ------KEKWVTITPNFTHTPISNRKSSRSRNDGSRRN--------------------------- 175

  Fly   586 GVESRHPHAGRHPYGSRPATATSERVDSWRSSSSTTTAA---------FDEQRSGAAGGAGAAGT 641
            |...|..:...|....|....:.|: |:.||..|:..:|         |..|...:|.|.....|
pombe   176 GNGRRRGNYSSHGSNKRQTNYSREK-DASRSIDSSNPSAEYRDDINNTFGSQTVSSANGKEVPQT 239

  Fly   642 GVGSATRGPRRYRTPYRGGRQGRGGFSRQGPGRPTYRIPRHLLASGEYANYLPADAAGADSQSSY 706
            ...|::      :.|:.....|... |:||..:.:|:                    .:|||.|:
pombe   240 SEDSSS------QAPHHSSSSGHAP-SQQGGNKHSYK--------------------KSDSQQSF 277

  Fly   707 VLMGTH----------YFGNV--------PAAYIELDAN-------SIKEAIKKQVEYYFSVDNL 746
            ...|.:          ::.|:        |...:.::.|       .::..:..|:|||||::||
pombe   278 HHKGRNTRKGQRHNNGFYRNIANNIQGPFPNYPVVVNGNGVNPYLCDVQAFLTSQLEYYFSIENL 342

  Fly   747 TGDFFLRRKMDPEGYIPVTLIASFHRVLALTTDVAVIVNAIKESDKLELF------EGYKVRTKT 805
            ..|.|||:.||.|||:|:..:|||:|:.:.:||:.::..|.|.||.:::.      ...|||.|.
pombe   343 CKDMFLRKHMDDEGYVPLAFLASFNRIKSFSTDLNLLHAACKASDIIDVAIDLQSPMSIKVRRKE 407

  Fly   806 TPTTWPITEVPEVNEGEPKAIGTLEQEQLEQNDGQEKLEEQTEADSPPPILTSAMATKPLNS--- 867
            |.:.|                       :..::.:.|.|.     :..|.:.|:.:..||.|
pombe   408 TWSPW-----------------------ILPSESRLKFEM-----AKYPQINSSSSMSPLASSIS 444

  Fly   868 ---IPPPPMPRNPQNLVPKMLQDKQQSR 892
               |.||.:|.:..:::.:.:|.:.:.:
pombe   445 NLTISPPFIPSSVDSIIKRDVQTEVEDK 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
larp	NP_001247347.1	LARP_1_2	730..803	CDD:153403	30/78 (38%)
		DM15	1341..1382	CDD:128927
		DM15	1383..1421	CDD:128927
SPAC1527.03	NP_594554.1	LHP1	4..473	CDD:227520	106/548 (19%)
SPAC1527.03	NP_594554.1	LA	323..406	CDD:128955	31/82 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	62	1.000	Domainoid score	I2964
eggNOG	1	0.900	-	-		E1_COG5193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001290
OrthoInspector	1	1.000	-	-		oto100639
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR22792
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1945
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.940