DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment larp and Larp4b

DIOPT Version :9

Sequence 1:	NP_001247347.1	Gene:	larp / 53567	FlyBaseID:	FBgn0261618	Length:	1673	Species:	Drosophila melanogaster
Sequence 2:	XP_011242555.1	Gene:	Larp4b / 217980	MGIID:	106330	Length:	1723	Species:	Mus musculus

Alignment Length:	1434	Identity:	266/1434 - (18%)
Similarity:	423/1434 - (29%)	Gaps:	509/1434 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 TVAASGSATTSYANVVQNLETKKSGTSNTTTTTARATVDNKENQPNLKSFKSWSEEAAAAEAAGE 82
            :|:.|| .|.|:.....||..:|..:.:.          :::..|...:||    |||.::..|.
Mouse   444 SVSRSG-RTLSFGLDKINLSPEKLASESL----------DRDYLPVHANFK----EAALSKLDGP 493

  Fly    83 SPI-------------------VGSVSLAQTGEKRAAASGGDNTAENSSELDDNNDFVPVLSHHR 128
            :||                   .||:.||..||....       :||||...| .|.:.:|....
Mouse   494 NPISHRGPVCVEEQPLGDSNLETGSIQLANRGELFLC-------SENSSICQD-EDKMSILETES 550

  Fly   129 RDRKKARKEKPRDQQPAGGRGDGQKPQQAGGRRVPGSSDTE---------RKSVRPRAPRGGSPR 184
            |.:::.:.....| ...|.|.|..:.:.....:|....|||         :..:..|.|...|..
Mouse   551 RAKRELKSWCQAD-VCRGNRADKAQRETYDLTQVKSEPDTEEVVQKADLLKLGLSQRMPNDESHS 614

  Fly   185 KSAAGAA-------GAAGSNAGAVSSAVPGGPKVHKDRKDTSPSASIEGAGSSGNEAKSADG--- 239
            :...|..       ...|..|.........|.|||                     .||..|
Mouse   615 RPHQGTVTPPAFIFTCTGPEARETGLHDKTGDKVH---------------------VKSLVGVLH 658

  Fly   240 DQQAGEKGAAGAAPPPKRFIAAPPPKVNAWKISAKQSGSPKAG----TSPLDKRV---------- 290
            :|.:|....|.|...|:        |.|..:|..|.:|:.::.    ||.|.|.|
Mouse   659 NQFSGPYVLANAEKEPQ--------KANYREICEKNTGNAESSFHWETSVLSKVVPNGNMVTCIG 715

  Fly   291 ----LQPKAQQQQ-QQTKQTASQNNNAQNTASNKKTQQQQQPQQGATTTTQTTTAAAAAATAAAA 350
                ..|..:..| :.:.:|...|.:...|...........|::....:.::....
Mouse   716 IGIAADPDCETNQIENSYRTDGVNEDPDLTVVPPLNHSLLSPEEEWANSDRSPDLC--------- 771

  Fly   351 ATAATTSAAAATSSAAAVPAATTETATTTTVDASQADALAKVVVKDKKKVNQKASDFSNVGDWPT 415
              ...|.:....|.|....|:.......|..:.::...|      ||...|..::
Mouse   772 --LINTESIQDVSKAFGNDASELSKEKLTCKEENETLGL------DKDSNNPNST---------- 818

  Fly   416 LIGGTSGSGKATSNEPKRNPTKKQQSAKTAAAVAASSNTTSSEVATESNVAGTTSSSNSNPSSST 480
               |..|..|          ||::::..|     ...:|...|:....|...|...:..:.||..
Mouse   819 ---GCLGPCK----------TKRKKARST-----VKESTLHGEIQFLGNSDVTFKKTALHDSSEV 865

  Fly   481 TTTNTTTNSQATTAPVASTSHDAKAQRDAEPAANS------------AAGTTGTAAGPALTKKIP 533
            .::.....|.....|.||.. :|.....|.||.|:            |:.|.|.:..|:
Mouse   866 CSSLIDVKSIRVDMPAASPG-NAPLAIPAIPADNTGCVVPSADQDHIASPTEGVSENPS------ 923

  Fly   534 KHKWRPLPID----LAKSSRPKPIGGRPNRRFSDDIADQRRPPRVYHDRQPG-AGGAGVESRHPH 593
            :..|..:|.:    ........|:||..::..|                  | |||
Mouse   924 EMDWHRIPEEFYAHFLNEFSYYPVGGLASQALS------------------GLAGG--------- 961

  Fly   594 AGRHPYGSRPATATSERVD----------------------------------------SWRSSS 618
            .||:..|...|...:|.:.                                        .|.|..
Mouse   962 CGRYQVGYLWANTATENMTEDAQFFNEDLHSKPQYLENTSFSLEQTPFQLPVTEDGVIWGWPSRG 1026

  Fly   619 S---TTTAAFDEQRSGAAGG-------AGAAGTGVGSATRGPRRYRTPYRGGRQGRGGFSRQGPG 673
            .   .||...:...:....|       |.:|..||.:|.                     .:.||
Mouse  1027 GQLVPTTKVSELNPNAKVWGTHMLHLEASSAAVGVNAAW---------------------EEAPG 1070

  Fly   674 RPTYRIPRHLL---ASGE----YANYLPADAAGADSQSSYVLMGTHYFGNVPAAYIELDANS--- 728
            .|| ...:.:|   |:|:    ..|....||..|:......|...|      :.|..|..|:
Mouse  1071 HPT-DCDQQVLGLDANGDGDKSRENAALPDAQEAEQTDMSTLALDH------SEYEPLPENNDTG 1128

  Fly   729 -----------IKEAIKKQVEYYFSVDNLTGDFFLRRKMDPEGYIPVTLIASFHRVLALTTDVAV 782
                       .:|.:||.:|:..|.:||..|.:|..:||.:.|:|:|.:|:...:..|:|||.:
Mouse  1129 GNESQPESQEDPREVLKKTLEFCLSRENLASDMYLISQMDSDQYVPITTVANLDHIKKLSTDVDL 1193

  Fly   783 IVNAIKESDKLELFE-GYKVR---------TKTTPTTWPITEVPEVNEGE--PKAIG-------- 827
            ||..::....:::.| |.|||         .:....:.|:.||..:.:|:  ||.|.
Mouse  1194 IVEVLRSLPLVQVDEKGEKVRPNQNRCIVILREISESTPVEEVEALFKGDNLPKFINCEFAYNDN 1258

  Fly   828 ---TLEQEQLEQNDGQEK---LEEQTEADSPPPILTSAMATK-------PLNSIPP--------- 870
               |.|.|.    |.|:.   |.|:.......||.....|..       |.|...|
Mouse  1259 WFITFETEA----DAQQAYKYLREEVRTFQGKPIKARIKAKAIAINTFLPKNGFRPLDMNLYTQQ 1319

  Fly   871 --------PPMPRNPQNLVPKMLQDKQQSRSSTIAALN-----------------------SVNA 904
                    ||: .:||...|.......|:.|:|.:.|:                       :.:.
Mouse  1320 RYATSFYLPPV-YSPQQQFPLYSLITPQTWSTTHSYLDPPLVTPFPSTGFINGFTSPTFKPATSP 1383

  Fly   905 ISALTQQVEGGAAELAGHL----------SGLAESVKP-----------KSTSTPDKRNAASA-- 946
            :::|.|...........||          .||.||  |           ....:|..|.|...
Mouse  1384 LTSLRQYPPRSRNPSKSHLRHAIPSTERGPGLLES--PSIFNFTADRLINGVRSPQTRQAGQTRT 1446

  Fly   947 -------------GNGAGSAAALVAEPEGIWK--------EVKRRSKTNAIKENATTPPQQQQPP 990
                         |.|....::|.:.| |:.:        ..||..|..:.:..:.|||:...|.
Mouse  1447 RIQNPSAYAKREIGTGRVEPSSLESSP-GLGRGRKNSFGYRKKREEKFTSSQTQSPTPPKPPSPS 1510

  Fly   991 LSQTLNN------NNDNVKTNNT-----------SSKSKSSSNNAPSNA---------SSSATVC 1029
            ....|:|      ...|:||.:.           |||.::.|.:|.:|.         |..|...
Mouse  1511 FELGLSNFPPLPGAAGNLKTEDLFENRLSSLIIGSSKERNLSTDASTNTVPVVGPREPSVPAPCA 1575

  Fly  1030 VTTNNASSAT--------KATTKTTTT-------STATTTTNNNIKSGNAA-------YSK---- 1068
            |:.....|.:        |...|...|       ||.|||...:::...||       |::
Mouse  1576 VSAAFERSPSPVHLPEDPKVAEKQRETQSVDRLPSTPTTTACKSVQVNGAATELRKPSYAEICQR 1640

  Fly  1069 -THSKSSSKTAAPPSAQ------CHAEKEELDFQFDEELMDPL--------------------PP 1106
             :...|||....||..|      |..|:::|....:.....|.                    ||
Mouse  1641 TSKDPSSSSPLQPPKEQKPSTVACGKEEKQLSEPVERHREPPALKSTPGVPKDQRRQPGRRASPP 1705

  Fly  1107 GTGR 1110
            ..|:
Mouse  1706 AAGK 1709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
larp	NP_001247347.1	LARP_1_2	730..803	CDD:153403	26/82 (32%)
		DM15	1341..1382	CDD:128927
		DM15	1383..1421	CDD:128927
Larp4b	XP_011242555.1	LARP_5	1141..1215	CDD:153405	25/73 (34%)
Larp4b	XP_011242555.1	RRM_LARP5	1220..1296	CDD:241150	17/79 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841861
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840