DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment larp and larp-1

DIOPT Version :9

Sequence 1:	NP_001247347.1	Gene:	larp / 53567	FlyBaseID:	FBgn0261618	Length:	1673	Species:	Drosophila melanogaster
Sequence 2:	NP_001040868.3	Gene:	larp-1 / 175680	WormBaseID:	WBGene00020097	Length:	1150	Species:	Caenorhabditis elegans

Alignment Length:	1544	Identity:	374/1544 - (24%)
Similarity:	555/1544 - (35%)	Gaps:	523/1544 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 ENQPNLKSFKSWSEEAAAAEAAGESPIVGSVSLAQTGEKRAAASGGDNTAENSSELDDNNDFVPV 123
            |.||.|...|..|.:|..|.:..:             :.:.......::.:|.:...:.....|
Worm     3 EKQPMLSFAKVVSGQAEDASSPSQ-------------QVQHTQDSSHSSTQNENSQPEKQAHPP- 53

  Fly   124 LSHHRRDRKK--ARKEKPRDQQPAGGRGDGQKPQQAGGRRVP-GSSDTERKSVRPRAPRGGSPRK 185
              |:||:::.  .|.|:||      |.|.|::.....|.|.| |.:.||:.
Worm    54 --HNRREKENVGGRSERPR------GEGKGKRRNNRKGDRKPRGETKTEKP-------------- 96

  Fly   186 SAAGAAGAAGSNAGAVSSAVPGGPKVHKDRKDTSPSASIEGAGSSGNEAKSADGDQQAGEKGAAG 250
                |...|......|...|...|         :|..:|.....:..||::|....|..:|....
Worm    97 ----AEKVATEEVKPVEIPVVLEP---------APLPAINAWFKNKEEAEAAAAAAQKEQKSETA 148

  Fly   251 AAPPPKRFIAAPPPKVNAWKISAKQSGSPKAGTSPLDKRVLQPKAQQQQQQTKQTASQNNNAQNT 315
            |    .:||....|.|       ::|.:|    .|..||.::|..:|.             |...
Worm   149 A----DQFIITATPVV-------QKSSAP----IPEKKRAVEPTPKQA-------------APIK 185

  Fly   316 ASNKKTQQQQQPQQGATTTTQTTTAAAAAATAAAAATAATTSAAAATSSAAAVPAATTETATTTT 380
            ..:|..:.:::|       .:|:||                            ||||.....|.|
Worm   186 EKSKSRESKKEP-------WKTSTA----------------------------PAATAPVTETVT 215

  Fly   381 VDASQADALAKVVVKDKKKVNQKASDFSNVGDWPTLIGGTSGSGKATSNEPKRNPTKKQQSAKTA 445
            |.|:|                          |||||.........:.||....|.:......||.
Worm   216 VAATQ--------------------------DWPTLAKAELNGHVSPSNSDDNNESSSNSQHKTG 254

  Fly   446 AAVAASS--------------------NTTSSEVATESNVAGTTSSSNSNPSSSTTTTNTTTNSQ 490
            ..:..:|                    |.........:|.......|....|:|.......:.|:
Worm   255 GKMTKNSWKKVDISVDYGSKGKGAPRGNGGEKGTRRSANDEAVRRRSGEEDSASGDEQQYWSRSK 319

  Fly   491 ATTAPVASTSHDAKAQRDAEPAANSAAGTTGTAAGPALTKKIPKHKWRPLPIDLAKSSRPKPIGG 555
            ...:|:...|.|......:........||               |.|:....:.|.|..|.|
Worm   320 DNKSPINEMSSDRVVDSGSNGIYYQQGGT---------------HGWKKKVNNKAGSDMPTP--- 366

  Fly   556 RPNRRFSDDIADQRRPPRVYHDRQPGAGGAGVESRHPHAGRHPYGSRPATATSERVDSW------ 614
             ||.. |...::...|..:..|:.|...|....:  |.|.|:  |:.  |:|::..|.|
Worm   367 -PNST-SPHQSESNSPEHLPKDKAPIMNGNAKNA--PAANRN--GNN--TSTAKTGDYWHKNGGE 423

  Fly   615 RSSSSTTTAAF----DEQRSGAAGGAGAAGTGVGSATRGP---------------------RRYR 654
            |....:...|:    |..::.|...|....|......|||                     .:|.
Worm   424 RKEDKSQPKAYYQRNDRFQARANPHAPPKLTAAQRKERGPLPRWEDIEAGDDNFDYMTLMEAQYS 488

  Fly   655 TPYRGGRQGRGGFSRQ--------------------GPGRPTY-RIPRHLLASGEYANYLPADAA 698
            ..|...:|    |..|                    .|.||.. .:..||::.       |.|..
Worm   489 QYYGAPQQ----FEHQLDPHQASILIQQAQQHMASFAPFRPPMPMLSPHLMSP-------PLDRD 542

  Fly   699 G--------ADSQSSYVLMGTHYFGNVPAAYIELDANSIKEAIKKQVEYYFSVDNLTGDFFLRRK 755
            |        .:..::.:.....|  |.|.|...:..:::||.::||:|||||.:||..|||||||
Worm   543 GGVTSPVSNGEPINTAIPFAPIY--NPPTAPRPVTDDTLKEYVRKQIEYYFSEENLQKDFFLRRK 605

  Fly   756 MDPEGYIPVTLIASFHRVLALTTDVAVIVNAIKESDKLELF-EGYKVRTKTTPTTWPITEVPEVN 819
            |.||||:||.|||||.||.:||.|.::|:.|:|:|.|:::. :|.::|....||.||:  :|.|:
Worm   606 MGPEGYLPVALIASFPRVRSLTEDYSLILEALKDSTKVDMSPDGLQIRAPVNPTIWPL--MPTVS 668

  Fly   820 EGEPKAIGTLEQEQLEQNDGQEKLEEQTEADSPPPILTSAMATKPLNSIPPPPMPRNPQNLVPKM 884
                               |.:.|                          |.|..:.||
Worm   669 -------------------GADSL--------------------------PGPSSQAPQ------ 682

  Fly   885 LQDKQQSRSSTIAALNSVNAISALTQQVEGGAAELAGHLSGLAESVKPKSTSTPDKRNAASAGNG 949
             |.:|...::|.|.:.|                             :|:::|:..:
Worm   683 -QFRQNGPAATAAPVES-----------------------------QPQASSSKPQ--------- 708

  Fly   950 AGSAAALVAEPEGIWKEVKRR---------SKTNAIKENATTPPQQQQPPLSQTLNNNNDNVKTN 1005
                     :||. |:|||.|         |.:.:..:| ...|||||..|.|
Worm   709 ---------QPEE-WEEVKTRKGKGKGRLTSGSQSTNDN-KRQPQQQQKSLQQ------------ 750

  Fly  1006 NTSSKSKSSSNNAPSNASSSATVCVTTNNASSATKATTKTTTTSTATTTTNNNIKSGNAAYSKTH 1070
                                                                   ||
Worm   751 -------------------------------------------------------SG-------- 752

  Fly  1071 SKSSSKTAAPPSAQCHAEKEELDFQFDEELMDPLPPGTG------RINNFTENFSDDDESDYEFA 1129
                            :::.:||||||.|:..    |.|      |.....:.|....:|: |..
Worm   753 ----------------SDQPDLDFQFDNEISG----GGGSAQTPKRPEKSKKAFLSAIDSE-EIG 796

  Fly  1130 DRDINKLLIVAQVGRAPKHEGYDRTADFTSRTKITQDLENIINDGLVNYEEDLWTTTNVVADYKT 1194
            |..|:||:|:     .|.....|||.||::|::...:....:..||..|||:|||... ..|..|
Worm   797 DDVISKLIIM-----TPSRRTLDRTGDFSTRSQNQGEFNEEVEIGLRRYEEELWTVPQ-EKDIPT 855

  Fly  1195 --VNVISQADFEKLAG---GRNKSVLPPQVVPP----PPP---FEEDLDETLVGDTTLNST---L 1244
              |:.||...|.::.|   .:..|..||::..|    |.|   :.:...|......|:..:   .
Worm   856 SKVSTISAEQFNEMRGNEDAKKTSDEPPEIPLPSGTQPTPDSVWTKKAKERAAASVTVPKSPMQR 920

  Fly  1245 NNTLKSRRARFY-----AAPNSHSIDPRTPRKRKLRHTANPPVEAHVGWLLDTVEHRPRTTSMGS 1304
            ..:.:.:..|||     .||    :|.::|||:|.||:..||||..|.|:|...:..|
Worm   921 RESEEQKMNRFYPISKPTAP----LDAKSPRKKKTRHSEKPPVEMPVAWVLGREDALP------- 974

  Fly  1305 SAGTSPTASSYGSFGSSVPQSLPVFQHPSHALLKENNFTQQAYHKYHSRCLKERRRLGYGQSQEM 1369
            :|.....|||     |.||.:     |||.:||:|:.|.|..|..:...|||:|:.||| ...||
Worm   975 AAPIGIAASS-----SQVPAN-----HPSISLLQEDRFVQNVYSTWRQACLKQRKSLGY-DCAEM 1028

  Fly  1370 NTLYRFWSFFLRENFNKSMYNEFRSLALEDAGNGFRYGLECLFRFFSYGLEKKFRPNIYQDFQDE 1434
            ||||||||||||:|||::||.|||.||||||..|.|||:|.||||:||||||||||.||::|..:
Worm  1029 NTLYRFWSFFLRDNFNRNMYEEFRKLALEDAEIGSRYGIEALFRFYSYGLEKKFRPEIYKNFMKD 1093

  Fly  1435 TIADYETGQLYGLEKFWAFLKYYKNGEKLEVQPKLAEYLKSFKNIEDFR 1483
            ...|.:.|:||||||.:|||:..|..::|.|...|.:.|..:|:.:|||
Worm  1094 VTTDVQKGELYGLEKLFAFLQRSKIAKQLVVDDYLTKELNKYKSTDDFR 1142

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
larp	NP_001247347.1	LARP_1_2	730..803	CDD:153403	41/73 (56%)
		DM15	1341..1382	CDD:128927	23/40 (58%)
		DM15	1383..1421	CDD:128927	27/37 (73%)
larp-1	NP_001040868.3	LARP_1_2	580..654	CDD:153403	41/73 (56%)
		DM15	1001..1041	CDD:128927	23/40 (58%)
		DM15	1042..1080	CDD:128927	27/37 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160010
Domainoid	1	1.000	240	1.000	Domainoid score	I1263
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I1786
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001290
OrthoInspector	1	1.000	-	-		oto18026
orthoMCL	1	0.900	-	-		OOG6_103868
Panther	1	1.100	-	-	LDO	PTHR22792
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1945
SonicParanoid	1	1.000	-	-		X2271
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.920