DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment larp and larp-5

DIOPT Version :9

Sequence 1:	NP_001247347.1	Gene:	larp / 53567	FlyBaseID:	FBgn0261618	Length:	1673	Species:	Drosophila melanogaster
Sequence 2:	NP_491209.3	Gene:	larp-5 / 171942	WormBaseID:	WBGene00004147	Length:	760	Species:	Caenorhabditis elegans

Alignment Length:	840	Identity:	178/840 - (21%)
Similarity:	274/840 - (32%)	Gaps:	279/840 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   617 SSSTTTAAFDEQRSGAAGGAGAAGTGVGSATRGPRRYRTPYRGGRQGRGGFSRQGPGRPTYRIPR 681
            ||..|:.|.....|.:...:||:|.        |:....||...|:.:......||..|.
Worm    56 SSVGTSNAHSPGTSPSTSASGASGI--------PQPPPLPYWFNRECKSSLMMIGPQPPG----- 107

  Fly   682 HLLASGEYANYLPADAAGADSQSSYVLMGTHYFGNVPAA--YIELDANSIKEAIKKQVEYYFSVD 744
                        |:......|.||     |:.|  |||.  ...|....||:.:|.|:|||||.:
Worm   108 ------------PSSGMSMPSSSS-----TNQF--VPAVPPPPPLSREEIKQLLKNQLEYYFSRE 153

  Fly   745 NLTGDFFLRRKMDPEGYIPVTLIASFHRVLALTTDVAVIVNAIKESDKLELFEGY-KVRTKTTPT 808
            ||:.|.:|:.:||.:.|:|:.::|.|.:::.|||||.:||.|:|||..:||.|.: |||..|...
Worm   154 NLSSDRYLKCQMDSDNYVPINVLAGFPKIMRLTTDVDLIVEALKESTNVELDEKFEKVRAITKRK 218

  Fly   809 TWPITEVPE---------VNEGEPKAIGTLEQEQLEQNDG------------------QEKLEEQ 846
            ...|.|:||         :.:|.|     ....|...|||                  |.:..|.
Worm   219 VMLIREIPETHREEVVKLIADGPP-----YTDLQYGVNDGWYVTYENELDAQVAYVAVQHRKNEI 278

  Fly   847 TEADSPPPILTSAMATKPLNSIPPPPMPRNPQNLVPKMLQDKQQSRSSTIAALNSVNAISALTQQ 911
            |:......|.|...:|     ..|||             ::...|.:..:..|
Worm   279 TQKQVCARIKTCGPST-----FAPPP-------------EETPHSENGQMTTL------------ 313

  Fly   912 VEGGAAELAGHLSGLAESVK-----PKSTSTPDKRNAASAGNGAGSAAALVAEPEGIWKEVKRRS 971
              |...:...||..|.:::.     |.:|..|        |:...|....:..        ..|.
Worm   314 --GNGEQGTVHLRELGQTLSDYGFVPVATYRP--------GDPISSHFEYITP--------TFRF 360

  Fly   972 KTNAIKENATTPP----------------QQQQPPLSQTLNNNNDNVKTNNTSSKSKSSSNNAPS 1020
            ..|::..|...||                |||||||.|                       |.|.
Worm   361 SGNSLSYNPPMPPVPPLPPQHHQQHQQQQQQQQPPLLQ-----------------------NTPQ 402

  Fly  1021 NASSSATVCVTTNNASSATKATTKTTTTSTATTTTNNNIKSGNAAYSKTHSKSSSKTAAPPSAQC 1085
            .....::|..|..|....:.|::.:|.|:|:.....|..::|...|.::.|..|:      |.:.
Worm   403 PYYYGSSVSTTPRNYDEMSTASSNSTHTTTSNYNNRNGSRNGGNQYYESRSSFSN------SNEW 461

  Fly  1086 HAEKEELDFQFDEELMDPLPPGTGRINNFTENFSDD-----DESDYEFADRDINKLLIVAQVGRA 1145
            .:.                  |.|....|..|:|::     :.|:..:...:.|        |..
Worm   462 RSR------------------GGGNGGRFQNNYSENNGRQSNGSNGRWRGNNRN--------GAT 500

  Fly  1146 PKHEGYDRTADFTSRTKITQDLENIINDGLVNYE----EDLWTTTNVVAD------------YKT 1194
            ....||.:..:..:..:..|..||..|....:|:    .:.|.:.|   |            |..
Worm   501 TNGYGYQQHNNRQNHYQNGQQRENGENGHHNHYQNGQSSNSWWSGN---DGQTRQRKQQHNGYNN 562

  Fly  1195 VNVISQADFEKLAG-----------GRNKSVLPPQV--------VP-----PPPP------FEED 1229
            ...:|.:.....:.           ..:.|..|||.        ||     ||||      |:..
Worm   563 RPTVSSSSSSSTSSKYFSPDAVETPTNSGSSTPPQTSVRNPKYHVPTPTDLPPPPVWPAPNFDRR 627

  Fly  1230 LDETLVGDTTLNSTLNNTLKSR-------RARF--YAAPNSHSIDPRT----------------- 1268
            ...:....|| |:|.|....|.       |..|  ..||...|....|
Worm   628 RKSSETSFTT-NTTTNTLTPSTPVTPPVLRPAFSESKAPQEPSKPVETKENNKPALTDDFPLPEP 691

  Fly  1269 -PRKRKLRHTANPPVEAHVGWLLDTVEHRPRTTSMGSSAGTSPTASSYGSFGSSVPQSLP 1327
             |:|.|:....:..||.      |..:.:.|:..:..::..:|.|.|..||..:...|||
Worm   692 LPQKPKIETNHHSAVEK------DAEKIKVRSPPVVVASSPAPAAPSPFSFEETAFPSLP 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
larp	NP_001247347.1	LARP_1_2	730..803	CDD:153403	34/73 (47%)
		DM15	1341..1382	CDD:128927
		DM15	1383..1421	CDD:128927
larp-5	NP_491209.3	LARP_4_5_like	139..213	CDD:153400	34/73 (47%)
larp-5	NP_491209.3	RRM_LARP4_5_like	218..290	CDD:240876	14/76 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910