DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kat60 and RPT6

DIOPT Version :9

Sequence 1:	NP_001262276.1	Gene:	Kat60 / 53566	FlyBaseID:	FBgn0040208	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_011467.1	Gene:	RPT6 / 852834	SGDID:	S000003016	Length:	405	Species:	Saccharomyces cerevisiae

Alignment Length:	296	Identity:	112/296 - (37%)
Similarity:	166/296 - (56%)	Gaps:	32/296 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   295 ERKFQPNNHIEAELVDILERDILQKDPKVRWSDIADLHDAKRLLEEAVVLPMLMPDYFK--GIRR 357
            |.|..|       ||.::   :::|.|...:..:..|....:.::|.:.||:..|:.|:  ||.:
Yeast   127 ENKADP-------LVSLM---MVEKVPDSTYDMVGGLTKQIKEIKEVIELPVKHPELFESLGIAQ 181

  Fly   358 PWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSATLTSKYRGESEKMVRLLFEMARFYAPSTI 422
            | |||::.||||||||:||:|||......|..||.|.|..||.||..:|||.||.|||.:|||.|
Yeast   182 P-KGVILYGPPGTGKTLLARAVAHHTDCKFIRVSGAELVQKYIGEGSRMVRELFVMAREHAPSII 245

  Fly   423 FIDEIDSLCSRR-----GSESEHEASRRVKSELLVQMDGVGGGEEQAKVVMVLAATNFPWDIDEA 482
            |:|||||:.|.|     |.:||   .:|...|||.|:||.    |.:|.:.::.|||....:|.|
Yeast   246 FMDEIDSIGSTRVEGSGGGDSE---VQRTMLELLNQLDGF----ETSKNIKIIMATNRLDILDPA 303

  Fly   483 LRR--RLEKRIYIPLPSDEGREALLKINLREVKVDDSVDLTYVANELKGYSGADITNVCREASMM 545
            |.|  |::::|..|.||...|..:|:|:.|::.:...::|..||.::.|.||||:..||.||.|.
Yeast   304 LLRPGRIDRKIEFPPPSVAARAEILRIHSRKMNLTRGINLRKVAEKMNGCSGADVKGVCTEAGMY 368

  Fly   546 SMRRKIAGLTPEQIRQLATEEVDLPVSNKDFNEAMS 581
            ::|.:...:|.|.. :||..:    |.||:...|:|
Yeast   369 ALRERRIHVTQEDF-ELAVGK----VMNKNQETAIS 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kat60	NP_001262276.1	HCV_NS5a_C	<163..243	CDD:289693
		P-loop_NTPase	325..>381	CDD:304359	24/57 (42%)
		AAA	358..496	CDD:214640	68/144 (47%)
		AAA	362..495	CDD:278434	64/139 (46%)
		Vps4_C	<570..603	CDD:286426	5/12 (42%)
RPT6	NP_011467.1	RPT1	12..403	CDD:224143	112/296 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900